:Shock to Pyramidal Cells AMPA+NMDA with local Ca2+ pool

NEURON {
	POINT_PROCESS shock2pyrV
	NONSPECIFIC_CURRENT inmda, iampa
	RANGE initW
	RANGE Cdur_nmda, AlphaTmax_nmda, Beta_nmda, Erev_nmda, gbar_nmda, W_nmda, on_nmda, g_nmda
	RANGE Cdur_ampa, AlphaTmax_ampa, Beta_ampa, Erev_ampa, gbar_ampa, W_ampa, on_ampa, g_ampa
	RANGE pregid,postgid
}

UNITS {
	(mV) = (millivolt)
        (nA) = (nanoamp)
	(uS) = (microsiemens)
}

PARAMETER {
	initW = 9 : 14 : 9 : 6 : 25 : 20

	Cdur_nmda = 16.7650 (ms)
	AlphaTmax_nmda = .2659 (/ms)
	Beta_nmda = 0.008 (/ms)
	Erev_nmda = 0 (mV)
	gbar_nmda = .5e-3 (uS)

	Cdur_ampa = 1.4210 (ms)
	AlphaTmax_ampa = 3.8142 (/ms)
	Beta_ampa = 0.1429 (/ms)
	Erev_ampa = 0 (mV)
	gbar_ampa = 1e-3 (uS)
}

ASSIGNED {
	v (mV)

	inmda (nA)
	g_nmda (uS)
	on_nmda
	W_nmda

	iampa (nA)
	g_ampa (uS)
	on_ampa
	W_ampa

	t0 (ms)
	
	pregid
	postgid
}

STATE { r_nmda r_ampa }

INITIAL {
	on_nmda = 0
	r_nmda = 0
	W_nmda = initW

	on_ampa = 0
	r_ampa = 0
	W_ampa = initW

	t0 = -1
}

BREAKPOINT {
	SOLVE release METHOD cnexp
}

DERIVATIVE release {
	if (t0>0) {
		if (t-t0 < Cdur_nmda) {
			on_nmda = 1
		} else {
			on_nmda = 0
		}
		if (t-t0 < Cdur_ampa) {
			on_ampa = 1
		} else {
			on_ampa = 0
		}
	}
	r_nmda' = AlphaTmax_nmda*on_nmda*(1-r_nmda)-Beta_nmda*r_nmda
	r_ampa' = AlphaTmax_ampa*on_ampa*(1-r_ampa)-Beta_ampa*r_ampa

	g_nmda = gbar_nmda*r_nmda
	inmda = W_nmda*g_nmda*(v - Erev_nmda)*sfunc(v)

	g_ampa = gbar_ampa*r_ampa
	iampa = W_ampa*g_ampa*(v - Erev_ampa)
}

NET_RECEIVE(dummy_weight) {
	t0 = t
}

:::::::::::: FUNCTIONs and PROCEDUREs ::::::::::::

FUNCTION sfunc (v (mV)) {
	UNITSOFF
	sfunc = 1/(1+0.33*exp(-0.06*v))
	UNITSON
}