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Calcium influx during striatal upstates (Evans et al. 2013)

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Accession:150912
"... To investigate the mechanisms that underlie the relationship between calcium and AP timing, we have developed a realistic biophysical model of a medium spiny neuron (MSN). ... Using this model, we found that either the slow inactivation of dendritic sodium channels (NaSI) or the calcium inactivation of voltage-gated calcium channels (CDI) can cause high calcium corresponding to early APs and lower calcium corresponding to later APs. We found that only CDI can account for the experimental observation that sensitivity to AP timing is dependent on NMDA receptors. Additional simulations demonstrated a mechanism by which MSNs can dynamically modulate their sensitivity to AP timing and show that sensitivity to specifically timed pre- and postsynaptic pairings (as in spike timing-dependent plasticity protocols) is altered by the timing of the pairing within the upstate. …"
Reference:
1 . Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates. J Neurophysiol 110:1631-45 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.2 CACNA1B;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; STDP; Calcium dynamics;
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; AMPA; NMDA; Gaba; I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R; 
//***************************		MS Model, Version 5.0	**********************
//*************************** 	      MScell.p 			**********************
//			Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-836
//*****************************************************************************

*relative
*cartesian
*asymmetric
*lambda_warn

//*set_global ELEAK -0.070
//*set_global RA 1.0 
//*set_global RM 8.695652
//*set_global RM 1.8

*set_global CM 0.01
//*set_global EREST_ACT -0.085

*start_cell /library/tert_dend
tert_dend none 17.964 0 0 0.80
tert_dend2 . 17.964 0 0 0.79 
tert_dend3 . 17.964 0 0 0.78
tert_dend4 . 17.964 0 0 0.77
tert_dend5 . 17.964 0 0 0.76
tert_dend6 . 17.964 0 0 0.75
tert_dend7 . 17.964 0 0 0.74 
tert_dend8 . 17.964 0 0 0.73
tert_dend9 . 17.964 0 0 0.72
tert_dend10 . 17.964 0 0 0.71
tert_dend11 . 17.964 0 0 0.70
*makeproto /library/tert_dend

*start_cell /library/sec_dend

sec_dend none 12 0 0 1.200
*makeproto /library/sec_dend

*start_cell /library/prim_dend

prim_dend none 10.000 0 0 2.5
*makeproto /library/prim_dend

*start_cell
*spherical
*set_compt_param RA 4
soma none 16.000 0 0 16.000

*cylindrical

*set_compt_param RA 4
*compt /library/prim_dend
primdend1 soma 10 0 0 2.5
primdend2 soma 10 0 0 2.5
primdend3 soma 10 0 0 2.5
primdend4 soma 10 0 0 2.5

*set_compt_param RA 4
*compt /library/sec_dend
secdend1 primdend1 12 0 0 1.2
secdend2 primdend1 12 0 0 1.2
secdend3 primdend2 12 0 0 1.2
secdend4 primdend2 12 0 0 1.2
secdend5 primdend3 12 0 0 1.2
secdend6 primdend3 12 0 0 1.2
secdend7 primdend4 12 0 0 1.2
secdend8 primdend4 12 0 0 1.2

*set_compt_param        RA      4
*compt /library/tert_dend
tertdend1 secdend1 17.964  0  0  0.8
tertdend2 secdend1 17.964  0  0  0.8
tertdend3 secdend2 17.964  0  0  0.8
tertdend4 secdend2 17.964  0  0  0.8
tertdend5 secdend3 17.964  0  0  0.8
tertdend6 secdend3 17.964  0  0  0.8
tertdend7 secdend4 17.964  0  0  0.8
tertdend8 secdend4 17.964  0  0  0.8
tertdend9 secdend5 17.964  0  0  0.8
tertdend10 secdend5 17.964  0  0  0.8
tertdend11 secdend6 17.964  0  0  0.8
tertdend12 secdend6 17.964  0  0  0.8
tertdend13 secdend7 17.964  0  0  0.8
tertdend14 secdend7 17.964  0  0  0.8
tertdend15 secdend8 17.964  0  0  0.8
tertdend16 secdend8 17.964  0  0  0.8

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