Calcium influx during striatal upstates (Evans et al. 2013)

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Accession:150912
"... To investigate the mechanisms that underlie the relationship between calcium and AP timing, we have developed a realistic biophysical model of a medium spiny neuron (MSN). ... Using this model, we found that either the slow inactivation of dendritic sodium channels (NaSI) or the calcium inactivation of voltage-gated calcium channels (CDI) can cause high calcium corresponding to early APs and lower calcium corresponding to later APs. We found that only CDI can account for the experimental observation that sensitivity to AP timing is dependent on NMDA receptors. Additional simulations demonstrated a mechanism by which MSNs can dynamically modulate their sensitivity to AP timing and show that sensitivity to specifically timed pre- and postsynaptic pairings (as in spike timing-dependent plasticity protocols) is altered by the timing of the pairing within the upstate. …"
Reference:
1 . Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates. J Neurophysiol 110:1631-45 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.2 CACNA1B;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; STDP; Calcium dynamics;
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; AMPA; NMDA; Gaba; I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
//***************************		MS Model, Version 5.0	**********************
//*************************** 	      MScell.p 			**********************
//			Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-836
//*****************************************************************************

*relative
*cartesian
*asymmetric
*lambda_warn

*set_global RA 6.0 
//change Cm to account for no spines - make 3x higher?
*set_global CM 0.03  

*start_cell
*spherical
soma none 16.000 0 0 16.000

*cylindrical
primdend1 soma 12 0 0 1.7
primdend2 soma 12 0 0 1.7
primdend3 soma 12 0 0 1.7
primdend4 soma 12 0 0 1.7

secdend11 primdend1 14 0 0 1.4
secdend12 primdend1 14 0 0 1.4
secdend21 primdend2 14 0 0 1.4
secdend22 primdend2 14 0 0 1.4
secdend31 primdend3 14 0 0 1.4
secdend32 primdend3 14 0 0 1.4
secdend41 primdend4 14 0 0 1.4
secdend42 primdend4 14 0 0 1.4

tertdend1_1 secdend11 18  0  0  1.2
tertdend1_2 . 18 0 0 1.2 
tertdend1_3 . 18 0 0 1.2
tertdend1_4 . 18 0 0 1.2
tertdend1_5 . 18 0 0 1.2
tertdend1_6 . 18 0 0 1.2
tertdend1_7 . 18 0 0 1.2
tertdend1_8 . 18 0 0 1.2
tertdend1_9 . 18 0 0 1.2
tertdend1_10 . 18 0 0 1.2
tertdend1_11 . 18 0 0 1.2

tertdend2_1 secdend11 18  0  0  1.2
tertdend2_2 . 18 0 0 1.2 
tertdend2_3 . 18 0 0 1.2
tertdend2_4 . 18 0 0 1.2
tertdend2_5 . 18 0 0 1.2
tertdend2_6 . 18 0 0 1.2
tertdend2_7 . 18 0 0 1.2 
tertdend2_8 . 18 0 0 1.2
tertdend2_9 . 18 0 0 1.2
tertdend2_10 . 18 0 0 1.2
tertdend2_11 . 18 0 0 1.2

tertdend3_1 secdend12 18  0  0  1.2
tertdend3_2 . 18 0 0 1.2 
tertdend3_3 . 18 0 0 1.2
tertdend3_4 . 18 0 0 1.2
tertdend3_5 . 18 0 0 1.2
tertdend3_6 . 18 0 0 1.2
tertdend3_7 . 18 0 0 1.2 
tertdend3_8 . 18 0 0 1.2
tertdend3_9 . 18 0 0 1.2
tertdend3_10 . 18 0 0 1.2
tertdend3_11 . 18 0 0 1.2
   
tertdend4_1 secdend12 18  0  0  1.2
tertdend4_2 . 18 0 0 1.2 
tertdend4_3 . 18 0 0 1.2
tertdend4_4 . 18 0 0 1.2
tertdend4_5 . 18 0 0 1.2
tertdend4_6 . 18 0 0 1.2
tertdend4_7 . 18 0 0 1.2 
tertdend4_8 . 18 0 0 1.2
tertdend4_9 . 18 0 0 1.2
tertdend4_10 . 18 0 0 1.2
tertdend4_11 . 18 0 0 1.2
   
tertdend5_1 secdend21 18  0  0  1.2
tertdend5_2 . 18 0 0 1.2 
tertdend5_3 . 18 0 0 1.2
tertdend5_4 . 18 0 0 1.2
tertdend5_5 . 18 0 0 1.2
tertdend5_6 . 18 0 0 1.2
tertdend5_7 . 18 0 0 1.2 
tertdend5_8 . 18 0 0 1.2
tertdend5_9 . 18 0 0 1.2
tertdend5_10 . 18 0 0 1.2
tertdend5_11 . 18 0 0 1.2
   
tertdend6_1 secdend21 18  0  0  1.2
tertdend6_2 . 18 0 0 1.2 
tertdend6_3 . 18 0 0 1.2
tertdend6_4 . 18 0 0 1.2
tertdend6_5 . 18 0 0 1.2
tertdend6_6 . 18 0 0 1.2
tertdend6_7 . 18 0 0 1.2 
tertdend6_8 . 18 0 0 1.2
tertdend6_9 . 18 0 0 1.2
tertdend6_10 . 18 0 0 1.2
tertdend6_11 . 18 0 0 1.2
   
tertdend7_1 secdend22 18  0  0  1.2
tertdend7_2 . 18 0 0 1.2 
tertdend7_3 . 18 0 0 1.2
tertdend7_4 . 18 0 0 1.2
tertdend7_5 . 18 0 0 1.2
tertdend7_6 . 18 0 0 1.2
tertdend7_7 . 18 0 0 1.2 
tertdend7_8 . 18 0 0 1.2
tertdend7_9 . 18 0 0 1.2
tertdend7_10 . 18 0 0 1.2
tertdend7_11 . 18 0 0 1.2
   
tertdend8_1 secdend22 18  0  0  1.2
tertdend8_2 . 18 0 0 1.2 
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tertdend8_4 . 18 0 0 1.2
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tertdend8_7 . 18 0 0 1.2
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tertdend8_10 . 18 0 0 1.2
tertdend8_11 . 18 0 0 1.2
   
tertdend9_1 secdend31 18  0  0  1.2
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tertdend9_10 . 18 0 0 1.2
tertdend9_11 . 18 0 0 1.2
   
tertdend10_1 secdend31 18  0  0  1.2
tertdend10_2 . 18 0 0 1.2 
tertdend10_3 . 18 0 0 1.2
tertdend10_4 . 18 0 0 1.2
tertdend10_5 . 18 0 0 1.2
tertdend10_6 . 18 0 0 1.2
tertdend10_7 . 18 0 0 1.2 
tertdend10_8 . 18 0 0 1.2
tertdend10_9 . 18 0 0 1.2
tertdend10_10 . 18 0 0 1.2
tertdend10_11 . 18 0 0 1.2
   
tertdend11_1 secdend32 18  0  0  1.2
tertdend11_2 . 18 0 0 1.2 
tertdend11_3 . 18 0 0 1.2
tertdend11_4 . 18 0 0 1.2
tertdend11_5 . 18 0 0 1.2
tertdend11_6 . 18 0 0 1.2
tertdend11_7 . 18 0 0 1.2 
tertdend11_8 . 18 0 0 1.2
tertdend11_9 . 18 0 0 1.2
tertdend11_10 . 18 0 0 1.2
tertdend11_11 . 18 0 0 1.2
   
tertdend12_1 secdend32 18  0  0  1.2
tertdend12_2 . 18 0 0 1.2 
tertdend12_3 . 18 0 0 1.2
tertdend12_4 . 18 0 0 1.2
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tertdend12_6 . 18 0 0 1.2
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tertdend12_10 . 18 0 0 1.2
tertdend12_11 . 18 0 0 1.2
   
tertdend13_1 secdend41 18  0  0  1.2
tertdend13_2 . 18 0 0 1.2 
tertdend13_3 . 18 0 0 1.2
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tertdend13_10 . 18 0 0 1.2
tertdend13_11 . 18 0 0 1.2
   
tertdend14_1 secdend41 18  0  0  1.2
tertdend14_2 . 18 0 0 1.2 
tertdend14_3 . 18 0 0 1.2
tertdend14_4 . 18 0 0 1.2
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tertdend14_11 . 18 0 0 1.2
   
tertdend15_1 secdend42 18  0  0  1.2
tertdend15_2 . 18 0 0 1.2 
tertdend15_3 . 18 0 0 1.2
tertdend15_4 . 18 0 0 1.2
tertdend15_5 . 18 0 0 1.2
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tertdend15_10 . 18 0 0 1.2
tertdend15_11 . 18 0 0 1.2
   
tertdend16_1 secdend42 18  0  0  1.2
tertdend16_2 . 18 0 0 1.2 
tertdend16_3 . 18 0 0 1.2
tertdend16_4 . 18 0 0 1.2
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tertdend16_6 . 18 0 0 1.2
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tertdend16_9 . 18 0 0 1.2
tertdend16_10 . 18 0 0 1.2
tertdend16_11 . 18 0 0 1.2

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