Calcium influx during striatal upstates (Evans et al. 2013)

 Download zip file 
Help downloading and running models
Accession:150912
"... To investigate the mechanisms that underlie the relationship between calcium and AP timing, we have developed a realistic biophysical model of a medium spiny neuron (MSN). ... Using this model, we found that either the slow inactivation of dendritic sodium channels (NaSI) or the calcium inactivation of voltage-gated calcium channels (CDI) can cause high calcium corresponding to early APs and lower calcium corresponding to later APs. We found that only CDI can account for the experimental observation that sensitivity to AP timing is dependent on NMDA receptors. Additional simulations demonstrated a mechanism by which MSNs can dynamically modulate their sensitivity to AP timing and show that sensitivity to specifically timed pre- and postsynaptic pairings (as in spike timing-dependent plasticity protocols) is altered by the timing of the pairing within the upstate. …"
Reference:
1 . Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates. J Neurophysiol 110:1631-45 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.2 CACNA1B;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; STDP; Calcium dynamics;
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; AMPA; NMDA; Gaba; I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
//***************************		MS Model, Version 5.0	**********************
//*************************** 	      MScell.p 			**********************
//			Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-836
//*****************************************************************************

*relative
*cartesian
*asymmetric
*lambda_warn

//*set_global ELEAK -0.070
//*set_global RA 1.0 
//*set_global RM 8.695652
//*set_global RM 1.8
//*set_global CM 0.010 
//change Cm to account for no spines - make 3x higher?
*set_global CM 0.01  
//*set_global EREST_ACT -0.085

*start_cell /library/tert_dend
tert_dend none 35.927 0 0 0.80
tert_dend2 . 35.927 0 0 0.79 
tert_dend3 . 35.927 0 0 0.78
tert_dend4 . 35.927 0 0 0.77
tert_dend5 . 35.927 0 0 0.76
tert_dend6 . 35.927 0 0 0.75
tert_dend7 . 35.927 0 0 0.74 
tert_dend8 . 35.927 0 0 0.73
tert_dend9 . 35.927 0 0 0.72
tert_dend10 . 35.927 0 0 0.71
tert_dend11 . 35.927 0 0 0.70
*makeproto /library/tert_dend

*start_cell /library/sec_dend

sec_dend none 24.230 0 0 1.200
*makeproto /library/sec_dend

*start_cell /library/prim_dend

prim_dend none 20.000 0 0 2.5
*makeproto /library/prim_dend

*start_cell
*spherical
*set_compt_param RA 4
soma none 16.000 0 0 16.000

*cylindrical

*set_compt_param RA 4
*compt /library/prim_dend
primdend1 soma 20 0 0 2.5
primdend2 soma 20 0 0 2.5
primdend3 soma 20 0 0 2.5
primdend4 soma 20 0 0 2.5

*set_compt_param RA 4
*compt /library/sec_dend
secdend1 primdend1 24.23 0 0 1.2
secdend2 primdend1 24.23 0 0 1.2
secdend3 primdend2 24.23 0 0 1.2
secdend4 primdend2 24.23 0 0 1.2
secdend5 primdend3 24.23 0 0 1.2
secdend6 primdend3 24.23 0 0 1.2
secdend7 primdend4 24.23 0 0 1.2
secdend8 primdend4 24.23 0 0 1.2

*set_compt_param        RA      4
*compt /library/tert_dend
tertdend1 secdend1 35.927  0  0  0.8
tertdend2 secdend1 35.927  0  0  0.8
tertdend3 secdend2 35.927  0  0  0.8
tertdend4 secdend2 35.927  0  0  0.8
tertdend5 secdend3 35.927  0  0  0.8
tertdend6 secdend3 35.927  0  0  0.8
tertdend7 secdend4 35.927  0  0  0.8
tertdend8 secdend4 35.927  0  0  0.8
tertdend9 secdend5 35.927  0  0  0.8
tertdend10 secdend5 35.927  0  0  0.8
tertdend11 secdend6 35.927  0  0  0.8
tertdend12 secdend6 35.927  0  0  0.8
tertdend13 secdend7 35.927  0  0  0.8
tertdend14 secdend7 35.927  0  0  0.8
tertdend15 secdend8 35.927  0  0  0.8
tertdend16 secdend8 35.927  0  0  0.8

Loading data, please wait...