//genesis
//SynParams.g
str AMPAname = "AMPA"
float EkAMPA = 0.0
float AMPAtau1 = 1.1e-3 //wolf with qfact of 2 taken into account (t1 and t2)
float AMPAtau2 = 5.75e-3
float AMPAgmax = 0.171e-9 //0.342e-9 25%or 50% Gsyn for shindou test//593e-12 I changed this to make the NMDA/AMPA ratio more like 2.75/1 which is what Ding 2008 finds int corticalstriatal synapses
float AMPACaper = 0 //0.001 //percent AMPA conductance that is carried by calcium. value from wolf //more like 2/1 for thalamus so should be 0.47e-9 for thalamo-striatal syanpnse if NMDA is 0.94e-9 Rebekah Evans 6/25/10
float AMPAdes = 1 // 1 //desensitization factor, (depr_per_spike field of facsynchan)
float AMPAdestau = 100e-3 // 100e-3 // desensitixation t (how fast des recovers)
str GABAname = "GABA"
float GABAtau1 = 0.25e-3 // From Galarreta and Hestrin 1997
float GABAtau2 = 3.75e-3 //(used in Wolfs model)
float EkGABA = -0.060 //calculated Kerr and Plenz 2004 Erev for Cl, is -60 mV 5/2/12 RCE
float GABAgmax = 900e-12 //was 750, Sri uses 900 //Modified Koos 2004 (Wolf uses 435e-12)
int GABA2Spine = 0 // = 0, No GABA;
// 1, add GABA to spine head
// 2, add GABA to spine neck
int addCa2Spine = 1 // 0, no ca channels in spine,
//1, yes ca channels in spine (non-synaptic)
int ghk_yesno=1 //0 no ghk objects for NMDA, 1 add ghk to NMDA
//ghk reduction factor and hoook ups to calcium shells are in Addsynapticchannels.g
setclock 0 5e-6 //was 5e-6
// Simulation time step (Second)
setclock 1 2e-5 // time step for ascii output
//setclock 1 1e-4 // time step for graphic output
// parameters for NMDA subunits
// cortex
str subunit = "NR2A" // A= 50e-3, ctx = 112e-3 B=300e-3 taus
float EkNMDA = 0
float Kmg = 18 //18 new //3.57 old overwrites 1/eta in nmda_channel.g
float NMDAtau2 = {(50e-3)/2} //FAST// {(112.5e-3)/2}: ctx avg for .25 NR2B and .75 NR2A. (300e-3)/2 (NR2B) (50e-3)/2 (NR2A) 75+37.5 = 112.5
float NMDAgmax = {0.47e-9} //0.94e-9 NR2A and B from (Moyner et al., 1994 figure 7)
float NMDAperCa = 0.00 //HIGH// 0.05: percent calcium influx
float NMDAfactGHK = 35e-9 //adjustment factor for GHK to calcium shell/pool
float NMDACaGHK = {{NMDAperCa}*{NMDAfactGHK}}
float NMDAdes = 0 //1 //desensitization factor, (depr_per_spike field of facsynchan)
float NMDAdestau = 0 //200e-3 // desensitixation t (how fast des recovers)
str NMDAname = {subunit}
str outermostshell = "Ca_difshell_1"
str dummyshell = "stupid"
//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines.
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