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Calcium influx during striatal upstates (Evans et al. 2013)

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Accession:150912
"... To investigate the mechanisms that underlie the relationship between calcium and AP timing, we have developed a realistic biophysical model of a medium spiny neuron (MSN). ... Using this model, we found that either the slow inactivation of dendritic sodium channels (NaSI) or the calcium inactivation of voltage-gated calcium channels (CDI) can cause high calcium corresponding to early APs and lower calcium corresponding to later APs. We found that only CDI can account for the experimental observation that sensitivity to AP timing is dependent on NMDA receptors. Additional simulations demonstrated a mechanism by which MSNs can dynamically modulate their sensitivity to AP timing and show that sensitivity to specifically timed pre- and postsynaptic pairings (as in spike timing-dependent plasticity protocols) is altered by the timing of the pairing within the upstate. …"
Reference:
1 . Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates. J Neurophysiol 110:1631-45 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.2 CACNA1B;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; STDP; Calcium dynamics;
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; AMPA; NMDA; Gaba; I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R; 
                       //genesis
// MSsim.g 

/***************************		MS Model, Version 9.1	***************
*******************************************************************************
****************************** Begin includes *******************************/

str neuronname = "/cell"
str cellpath = "/cell"

str pfile="MScell/MScelltapershortCM3noproto.p"
include MScell/MScellSyn	//access make_MS_cell this function is only called from MSsim.g
include graphics7		        //access functions make_control & make_graph
include RebekahSims/Store_Parameters.g
include RebekahSims/SpikeMakerGrad.g
include RebekahSims/SpikeMakerFlat.g
include RebekahSims/add_outputBuffers.g	

		     
// These two functions are only called from MSsimSyn.g
/****************************** End includes *********************************/
float outputclock=2e-5

	setclock 0 5e-6   // Simulation time step (Second)       
	setclock 1 {outputclock}

	makeMScellSyn {neuronname} {pfile}	// MS_cell.g

	reset

/* these graphics no longer work because of some globals and cell names
 * need to edit to pass in neuronname, etc. But, would be better to write to file. */
//	make_control		// graphics.g


//	 make_graph {neuronname}		// graphics.g
		
/*uncomment the following lines (and one line in MScell.g) to use the hsolver
        setfield  {neuronname}  chanmode 1 
        call {neuronname} SETUP
        setmethod 11
*/	
	reset

/****************************** End MSsimSyn.g **********************************/
str diskpath1="11.008Syn3NaFdnoNMDA"

//Store_Parameters

//set random seed so for each simulation the randomspike train will be the same
//3 = 5757538
//5 = 9824501
//4 = 2394075
//6 = 492
//7 = 2370

//Flat input
/*
	randseed 5757538
include RebekahSims/USnoAP.g
	DeleteAllSpikesFlat
	randseed 5757538
include RebekahSims/US10.g
	DeleteAllSpikesFlat
	randseed 5757538
include RebekahSims/US20.g
	DeleteAllSpikesFlat
	randseed 5757538
include RebekahSims/US30.g
	DeleteAllSpikesFlat
	randseed 5757538
include RebekahSims/US50.g
	DeleteAllSpikesFlat
	randseed 5757538
include RebekahSims/US100.g
	DeleteAllSpikesFlat
	randseed 5757538
include RebekahSims/US175.g
	DeleteAllSpikesFlat
	randseed 5757538
include RebekahSims/US290.g
	DeleteAllSpikesFlat
*/
//Input Gradient

	randseed 5757538
include RebekahSims/USnoAPgrad.g
	deleteALLspikesGrad
	randseed 5757538
include RebekahSims/US10grad.g
	deleteALLspikesGrad
	randseed 5757538
include RebekahSims/US20grad.g
	deleteALLspikesGrad
	randseed 5757538
include RebekahSims/US30grad.g
	deleteALLspikesGrad
	randseed 5757538
include RebekahSims/US50grad.g
	deleteALLspikesGrad
	randseed 5757538
include RebekahSims/US100grad.g
	deleteALLspikesGrad
	randseed 5757538
include RebekahSims/US175grad.g
	deleteALLspikesGrad
	randseed 5757538
include RebekahSims/US290grad.g
	deleteALLspikesGrad

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