Advanced search
SenseLab
SimToolDB
ModelDB Help
User account
Login
Register
Find models by
Model name
First author
Each author
Region(circuits)
Find models for
Cell type
Current
Receptor
Gene
Transmitters
Concept
Simulators
Methods
Find models of
Realistic Networks
Neurons
Electrical synapses (gap junctions)
Chemical synapses
Ion channels
Neuromuscular junctions
Axons
Pathophysiology
Other resources
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Download zip file
Help downloading and running models
Model Information
Model File
Citations
Versions on GitHub
Accession:
151126
Several recent results suggest that boosting the CREB pathway improves hippocampal-dependent memory in healthy rodents and restores this type of memory in an AD mouse model. However, not much is known about how CREB-dependent neuronal alterations in synaptic strength, excitability and LTP can boost memory formation in the complex architecture of a neuronal network. Using a model of a CA1 microcircuit, we investigate whether hippocampal CA1 pyramidal neuron properties altered by increasing CREB activity may contribute to improve memory storage and recall. With a set of patterns presented to a network, we find that the pattern recall quality under AD-like conditions is significantly better when boosting CREB function with respect to control. The results are robust and consistent upon increasing the synaptic damage expected by AD progression, supporting the idea that the use of CREB-based therapies could provide a new approach to treat AD.
Reference:
1 .
Bianchi D, De Michele P, Marchetti C, Tirozzi B, Cuomo S, Marie H, Migliore M (2014) Effects of increasing CREB-dependent transcription on the storage and recall processes in a hippocampal CA1 microcircuit.
Hippocampus
24
:165-77
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Hippocampus CA1 interneuron oriens alveus GABA cell;
Hippocampus CA1 basket cell;
Channel(s):
I Na,t;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I_AHP;
I Cl, leak;
Ca pump;
Gap Junctions:
Receptor(s):
GabaA;
GabaB;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
STDP;
Aging/Alzheimer`s;
Depolarization block;
Storage/recall;
CREB;
Implementer(s):
Bianchi, Daniela [danielabianchi12 -at- gmail.com];
De Michele, Pasquale [pasquale.demichele at unina.it];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
Hippocampus CA1 interneuron oriens alveus GABA cell
;
GabaA
;
GabaB
;
AMPA
;
NMDA
;
I Na,t
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I_AHP
;
I Cl, leak
;
Ca pump
;
Gaba
;
Glutamate
;
Download the displayed file
/
Bianchietal
Results
Weights
readme.txt
ANsyn.mod
*
Other models using ANsyn.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Signal integration in a CA1 pyramidal cell (Graham 2001)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
bgka.mod
*
Other models using bgka.mod:
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
burststim2.mod
*
Other models using burststim2.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
cad.mod
*
Other models using cad.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
cagk.mod
*
Other models using cagk.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
cal.mod
*
Other models using cal.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
calH.mod
*
Other models using calH.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
car.mod
*
Other models using car.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
cat.mod
*
Other models using cat.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
ccanl.mod
*
Other models using ccanl.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
d3.mod
*
Other models using d3.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
gskch.mod
*
Other models using gskch.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
h.mod
*
Other models using h.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
IA.mod
ichan2.mod
*
Other models using ichan2.mod:
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Ih.mod
*
Other models using Ih.mod:
Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003)
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
kadist.mod
*
Other models using kadist.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
kaprox.mod
*
Other models using kaprox.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Kaxon.mod
*
Other models using Kaxon.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
kca.mod
*
Other models using kca.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Kdend.mod
*
Other models using Kdend.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
kdr.mod
*
Other models using kdr.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
kdrax.mod
*
Other models using kdrax.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
km.mod
*
Other models using km.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Ksoma.mod
*
Other models using Ksoma.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
LcaMig.mod
*
Other models using LcaMig.mod:
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
my_exp2syn.mod
*
Other models using my_exp2syn.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
na3.mod
*
Other models using na3.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
na3dend.mod
*
Other models using na3dend.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
na3notrunk.mod
*
Other models using na3notrunk.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Naaxon.mod
*
Other models using Naaxon.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Nadend.mod
*
Other models using Nadend.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
nap.mod
*
Other models using nap.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Nasoma.mod
*
Other models using Nasoma.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
nax.mod
*
Other models using nax.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
nca.mod
*
Other models using nca.mod:
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
nmdanet.mod
*
Other models using nmdanet.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
regn_stim.mod
*
Other models using regn_stim.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
somacar.mod
*
Other models using somacar.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
STDPE2Syn2.mod
*
Other models using STDPE2Syn2.mod:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
axoaxonic_cell17S.hoc
*
Other models using axoaxonic_cell17S.hoc:
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
basket_cell17S.hoc
*
Other models using basket_cell17S.hoc:
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
bistratified_cell13S.hoc
*
Other models using bistratified_cell13S.hoc:
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
burst_cell.hoc
*
Other models using burst_cell.hoc:
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
HAM_SR1.ses
mosinit.hoc
olm_cell2.hoc
PureRec_phase.hoc
PureRec_phase_ser.hoc
pyramidal_cell4.hoc
ranstream.hoc
*
Other models using ranstream.hoc:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Translating network models to parallel hardware in NEURON (Hines and Carnevale 2008)
stim_cell.hoc
*
Other models using stim_cell.hoc:
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Sto_phase.hoc
Sto_phase_ser.hoc
load_file("Sto_phase_ser.hoc")
Loading data, please wait...
