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Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
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Accession:
151282
" ... We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of Ih. Our model demonstrated that modulation of pyramidal and basket Ih allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal Ih also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via Ih’s ability to set pyramidal excitability. ..."
Reference:
1 .
Neymotin SA, Hilscher MM, Moulin TC, Skolnick Y, Lazarewicz MT, Lytton WW (2013) Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model.
PLoS One
8
:e76285
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA3 interneuron basket GABA cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s):
I Na,t;
I A;
I K;
I K,leak;
I h;
I K,Ca;
I Sodium;
I Potassium;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Glutamate;
Gene(s):
HCN1;
HCN2;
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Oscillations;
Brain Rhythms;
Conductance distributions;
Multiscale;
Implementer(s):
Lazarewicz, Maciej [mlazarew at gmu.edu];
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Search NeuronDB
for information about:
Hippocampus CA3 pyramidal GLU cell
;
Hippocampus CA3 interneuron basket GABA cell
;
GabaA
;
AMPA
;
NMDA
;
Glutamate
;
I Na,t
;
I A
;
I K
;
I K,leak
;
I h
;
I K,Ca
;
I Sodium
;
I Potassium
;
Gaba
;
Glutamate
;
/
ca3ihdemo
readme.txt
CA3ih.mod
CA3ika.mod
CA3ikdr.mod
CA3ina.mod
caolmw.mod
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HCN1.mod
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iholmw.mod
*
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ihstatic.mod
*
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kcaolmw.mod
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kdrbwb.mod
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MyExp2SynBB.mod
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Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
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MyExp2SynNMDABB.mod
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Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
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Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
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default.hoc
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Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
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Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
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geom.py
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Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
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Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
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network.py
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