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Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
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Accession:
151458
We construct an electric compartment model of the striatal medium spiny neuron with a realistic morphology and predict the calcium responses in the synaptic spines with variable timings of the glutamatergic and dopaminergic inputs and the postsynaptic action potentials. The model was validated by reproducing the responses to current inputs and could predict the electric and calcium responses to glutamatergic inputs and back-propagating action potential in the proximal and distal synaptic spines during up and down states.
Reference:
1 .
Nakano T, Yoshimoto J, Doya K (2013) A model-based prediction of the calcium responses in the striatal synaptic spines depending on the timing of cortical and dopaminergic inputs and post-synaptic spikes.
Front Comput Neurosci
7
:119
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I A;
I K;
I K,leak;
I K,Ca;
I CAN;
I Sodium;
I Calcium;
I Potassium;
I A, slow;
I Krp;
I R;
I Q;
I Na, leak;
I Ca,p;
Ca pump;
Gap Junctions:
Receptor(s):
D1;
AMPA;
NMDA;
Glutamate;
Dopaminergic Receptor;
IP3;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Reinforcement Learning;
STDP;
Calcium dynamics;
Reward-modulated STDP;
Implementer(s):
Nakano, Takashi [nakano.takashi at gmail.com];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
D1
;
AMPA
;
NMDA
;
Glutamate
;
Dopaminergic Receptor
;
IP3
;
I Na,p
;
I Na,t
;
I L high threshold
;
I A
;
I K
;
I K,leak
;
I K,Ca
;
I CAN
;
I Sodium
;
I Calcium
;
I Potassium
;
I A, slow
;
I Krp
;
I R
;
I Q
;
I Na, leak
;
I Ca,p
;
Ca pump
;
Download the displayed file
/
Nakano_FICN_model
tau_tables
CVS
tauh_car.txt
*
Other models using tauh_car.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_cat.txt
*
Other models using tauh_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_kas.txt
*
Other models using tauh_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_krp.txt
*
Other models using tauh_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_naf.txt
*
Other models using tauh_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_nap.txt
*
Other models using tauh_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_cat.txt
*
Other models using taum_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kaf.txt
*
Other models using taum_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kas.txt
*
Other models using taum_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kir.txt
*
Other models using taum_kir.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_krp.txt
*
Other models using taum_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_naf.txt
*
Other models using taum_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_car.txt
*
Other models using vtau_car.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_cat.txt
*
Other models using vtau_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kaf.txt
*
Other models using vtau_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kas.txt
*
Other models using vtau_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kir.txt
*
Other models using vtau_kir.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_krp.txt
*
Other models using vtau_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_naf.txt
*
Other models using vtau_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_nap.txt
*
Other models using vtau_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
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