ModelDB: Sympathetic Preganglionic Neurone (Briant et al. 2014)

Sympathetic Preganglionic Neurone (Briant et al. 2014)

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Accession:151482

A model of a sympathetic preganglionic neurone of muscle vasoconstrictor-type.
Reference:
1 . Briant LJ, Stalbovskiy AO, Nolan MF, Champneys AR, Pickering AE (2014) Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats. J Neurophysiol 112:2756-78 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Spinal cord lumbar motor neuron alpha ACh cell; Spinal cord sympathetic preganglionic neuron;
Channel(s):	I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON; MATLAB;
Model Concept(s):	Action Potential Initiation; Activity Patterns; Bursting; Ion Channel Kinetics; Temporal Pattern Generation; Parameter Fitting; Action Potentials; Parameter sensitivity;
Implementer(s):

Search NeuronDB for information about: Spinal cord lumbar motor neuron alpha ACh cell; I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I_AHP;

Download the displayed file

ActivationProtocol_GKA.dat

ActivationProtocol_IA.dat

ActivationProtocol_V.dat

ClampFiddy_vhalfm.dat

ClampFiddy_ZetaK.dat

ClampFiddy_ZetaM.dat

ClampHundred.dat

ClampHundred_vhalfm.dat

ClampHundred_ZetaK.dat

ClampHundred_ZetaM.dat

CurrentMagnitude_GKA.dat

CurrentMagnitude_IA.dat

CurrentMagnitude_V.dat

EPSCs_Filtered.txt

InactivationProtocol_GKA.dat

InactivationProtocol_IA.dat

InactivationProtocol_V.dat

NEURON {
	POINT_PROCESS gap
	NONSPECIFIC_CURRENT i
	RANGE r, i
	POINTER vgap
}
PARAMETER {
	v (millivolt)
	vgap (millivolt)
	r = 1e10 (megohm)
}
ASSIGNED {
	i (nanoamp)
}
BREAKPOINT {
	i = (v - vgap)/r
}

Fig. 3Ab
Fig. 3B

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