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Electrodiffusive astrocytic and extracellular ion concentration dynamics model (Halnes et al. 2013)

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An electrodiffusive formalism was developed for computing the dynamics of the membrane potential and ion concentrations in the intra- and extracellular space in a one-dimensional geometry (cable). This (general) formalism was implemented in a model of astrocytes exchanging K+, Na+ and Cl- ions with the extracellular space (ECS). A limited region (0< x<l/10 where l is the astrocyte length) of the ECS was exposed to an increase in the local K+ concentration. The model is used to explore how astrocytes contribute in transporting K+ out from high-concentration regions via a mechanism known as spatial buffering, which involves local uptake from high concentration regions, intracellular transport, and release of K+ in regions with lower ECS concentrations.
1 . Halnes G, Ostby I, Pettersen KH, Omholt SW, Einevoll GT (2013) Electrodiffusive model for astrocytic and neuronal ion concentration dynamics. PLoS Comput Biol 9:e1003386 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Glia; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Astrocyte;
Channel(s): I K,leak; Na/K pump; I Cl, leak; I Na, leak;
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Methods; Potassium buffering;
Implementer(s): Halnes, Geir [geir.halnes at];
Search NeuronDB for information about:  I K,leak; Na/K pump; I Cl, leak; I Na, leak;
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