A model of local field potentials generated by medial superior olive neurons (Goldwyn et al 2014)

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Accession:152112
A computational model of local field potentials generated by medial superior olive neurons. These field potentials are known as the "auditory neurophonic". MSO neuron is modeled as a soma and two dendrites (following Mathews et al, Nature Neurosci, 2010). Intracellular and a 1D extracellular domain are dynamically coupled and solved to simulate spatial-temporal patterns of membrane voltage and extracellular voltage in response to trains of synaptic inputs (monolateral or bilateral, excitation and/or inhibition). The model produces spatio-temporal patterns similar to neurophonic responses recorded in vivo, as discussed in the accompanying manuscript.
Reference:
1 . Goldwyn JH, Mc Laughlin M, Verschooten E, Joris PX, Rinzel J (2014) A model of the medial superior olive explains spatiotemporal features of local field potentials. J Neurosci 34:11705-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Medial Superior Olive (MSO) cell;
Channel(s): I h; I_KLT;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Evoked LFP;
Implementer(s): Goldwyn, Joshua [jhgoldwyn at gmail.com];
Search NeuronDB for information about:  I h; I_KLT;
 
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GoldwynEtAl2014
                            
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