Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
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striatalnetwork
FScell
channels
AddSynapticChannels.g *
AddSynapticChannels.g~ *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.g~ *
FScell.p *
FScell.p~ *
FScellSyn.g *
FScellSyn.g~ *
include_channels.g *
include_channels.g~ *
proto.g *
proto.g~ *
SynParams.g *
SynParams.g~ *
                            
//////////////////////////////////////////////////////////////////////////
//
// Johannes Hjorth, june 2005
// hjorth@nada.kth.se
// Sriraman Damodaran, september 2010
// FScell.g - Creates a fast spiking neuron in the library
//
//////////////////////////////////////////////////////////////////////////
//
// make_FS_cell -- Creates the library template for a FS-neuron 
//
//////////////////////////////////////////////////////////////////////////
include FScell/proto.g

//************************ Begin function set_position *********************
//**************************************************************************
function set_position (cellpath)
//********************* Begin Local Variables ************************
str compt, cellpath
float dist2soma,x,y,z
//********************* End Local Variables *****************************
 		
if (!{exists {cellpath}})
  echo The current input {cellpath} does not exist (set_position) 
  return
end
 
  foreach compt ({el {cellpath}/##[TYPE=compartment]})
     	 x={getfield {compt} x}
     	 y={getfield {compt} y}
     	 z={getfield {compt} z}
     	dist2soma={sqrt {({pow {x} 2 }) + ({pow {y} 2}) + ({pow {z} 2})} }  
     	setfield {compt} position {dist2soma}
   end
end
	//************************ End function set_position ***********************
	//**************************************************************************


function make_FS_cell (cellpath,pfile)
  str cellpath,pfile

  make_prototypes		// see proto.g
  readcell {pfile} {cellpath}
  set_position {cellpath}	// local call
// Number of inputs to each compartmenttype

  addfield {cellpath} somaDensityAMPA
  addfield {cellpath} somaDensityNMDA
  addfield {cellpath} somaDensityGABA

  addfield {cellpath} primDensityAMPA
  addfield {cellpath} primDensityNMDA
  addfield {cellpath} primDensityGABA

  addfield {cellpath} secDensityAMPA
  addfield {cellpath} secDensityNMDA
  addfield {cellpath} secDensityGABA

  addfield {cellpath} tertDensityAMPA
  addfield {cellpath} tertDensityNMDA
  addfield {cellpath} tertDensityGABA

// Weights of each input

  addfield {cellpath} somaWeightAMPA
  addfield {cellpath} somaWeightNMDA
  addfield {cellpath} somaWeightGABA

  addfield {cellpath} primWeightAMPA
  addfield {cellpath} primWeightNMDA
  addfield {cellpath} primWeightGABA

  addfield {cellpath} secWeightAMPA
  addfield {cellpath} secWeightNMDA
  addfield {cellpath} secWeightGABA

  addfield {cellpath} tertWeightAMPA
  addfield {cellpath} tertWeightNMDA
  addfield {cellpath} tertWeightGABA


// Set default values for densities

  setfield {cellpath} somaDensityAMPA 1
  setfield {cellpath} somaDensityNMDA 1
  setfield {cellpath} somaDensityGABA 3

  setfield {cellpath} primDensityAMPA 1
  setfield {cellpath} primDensityNMDA 1
  setfield {cellpath} primDensityGABA 3

  setfield {cellpath} secDensityAMPA  1
  setfield {cellpath} secDensityNMDA  1
  setfield {cellpath} secDensityGABA  3

  setfield {cellpath} tertDensityAMPA 1
  setfield {cellpath} tertDensityNMDA 1
  setfield {cellpath} tertDensityGABA 0


// Set default values for synapse weights

  setfield {cellpath} somaWeightAMPA 1.0
  setfield {cellpath} somaWeightNMDA 1.0
  setfield {cellpath} somaWeightGABA 1.0

  setfield {cellpath} primWeightAMPA 1.0
  setfield {cellpath} primWeightNMDA 1.0
  setfield {cellpath} primWeightGABA 1.0

  setfield {cellpath} secWeightAMPA  1.0
  setfield {cellpath} secWeightNMDA  1.0
  setfield {cellpath} secWeightGABA  1.0

  setfield {cellpath} tertWeightAMPA 1.0
  setfield {cellpath} tertWeightNMDA 1.0
  setfield {cellpath} tertWeightGABA 1.0

end

//////////////////////////////////////////////////////////////////////////

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