Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
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striatalnetwork
MScell
channels
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g *
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
naF_chanOg.g~
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis

/***************************		MS Model, Version 5.2	*********************
**************************** 	  		CaR_channel.g 			*********************
		Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************
max cond is now a parameter in globals, though use in this function is irrelevant
******************************************************************************/

function create_CaR
	str chanName = "CaR_channel"
	str compPath = "/library"

	int c = 0	
	int xdivs = 3000

	float x = -0.1
	float xmin = -0.1
	float xmax = 0.05
        float increment ={{xmax}-{xmin}}/{xdivs}
        echo "CaR increment:" {increment} "V"
  	float mPower = 1.0
  	float hPower = 1.0

	float mvHalfCaR = -10.3e-3
	float mkCaR     = -6.6e-3
	float hvHalfCaR = -33.3e-3
	float hkCaR     = 17e-3

	float mTauCaR = 1.7e-003
	float mInfCaR = 0.0
	float hTauCaR = 0.0
	float hInfCaR = 0.0

	float surf = 0.0
	float gMax = 2.6e-007

	float theta = 0.0
	float theta_exp = 0.0

	create tabchannel {chanName}
  	setfield {chanName} Xpower {mPower} Ypower {hPower}
	call {chanName} TABCREATE X {xdivs} {xmin} {xmax}
   call {chanName} TABCREATE Y {xdivs} {xmin} {xmax}

	for(c = 0; c < {xdivs} + 1; c = c + 1)
		/************************ Begin CaR_mTau *********************/
		// mTauCaR = 1.7e-3*ones(vDiv+1,1); 
		mTauCaR = 1.7e-003
		setfield {chanName} X_A->table[{c}] {mTauCaR}
		/************************ End CaR_mTau ***********************/
		
		/************************ Begin CaR_mInf *********************/
		//mInfCaR   = 1./(1 + exp((vMemb - mvHalfCaR)/mkCaR));
		theta = {{x} - {mvHalfCaR}}/{mkCaR}
		theta_exp = {exp {theta}} + 1.0
		mInfCaR = 1.0/{theta_exp}
		setfield {chanName} X_B->table[{c}] {mInfCaR}
		/************************ End CaR_mInf ***********************/

		/************************ Begin CaR_hTau *********************/
		//genCarTauH = nfCarTauH * 1e-3 / qFactCaR;
		//genCarV = nfCarV * 1e-3;
		//genCarVmax = max(nfCarV * 1e-3);
		//genCarVmin = min(nfCarV * 1e-3);
		//genCarVxdiv = length(nfCarV) - 1;
		//hTauCaR = interp1(genCarV, genCarTauH, vMemb,'pchip');
		//hTauCaR(find(vMemb < min(genCarV))) = 
		//					genCarTauH(find(genCarV==min(genCarV)));
		//hTauCaR(find(vMemb > max(genCarV))) = 
		//					genCarTauH(find(genCarV==max(genCarV))); 
		if(x <= -0.03)
			hTauCaR = 0.03333
		else
			if(x <= -0.01)
				hTauCaR = -1.08*{x} + 0.0009
			else
				if(x <= 0.01)
					hTauCaR = -0.25*{x} + 0.0092
				else
					hTauCaR = 0.0067
				end
			end
		end
		setfield {chanName} Y_A->table[{c}] {hTauCaR}
		/************************ End CaR_hTau ***********************/
		
		/************************ Begin CaR_hInf *********************/
		//hInfCaR   = 1./(1 + exp((vMemb - hvHalfCaR)/hkCaR));
		theta = {{x} - {hvHalfCaR}}/{hkCaR}
		theta_exp = {exp {theta}} + 1.0
		hInfCaR = 1.0/{theta_exp}
		setfield {chanName} Y_B->table[{c}] {hInfCaR}
		/************************ End CaR_hInf ***********************/
    	x = x + increment
	end

	tweaktau {chanName} X
	tweaktau {chanName} Y

  	create ghk {chanName}GHK

  	setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, 
											// Wolf 5mM
  	setfield {chanName}GHK valency 2.0
  	setfield {chanName}GHK T {TEMPERATURE}
	
  	setfield {chanName} Gbar {gMax*surf}
  	addmsg {chanName} {chanName}GHK PERMEABILITY Gk	
  	pope
end



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