Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
ModelDB is moving. Check out our new site at
The corresponding page is
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Download zip file
Help downloading and running models
NEURON mod files from the paper: M. Migliore, et al. (2015). In this paper, we investigate the possibility that the experimental protocols on synaptic plasticity may result in different consequences (e.g., LTD instead of LTP), according to the initial conditions of the stimulated synapses, and can generate confusing results. Using biophysical models of synaptic plasticity and hippocampal CA1 pyramidal neurons, we study how, why, and to what extent EPSPs observed at the soma after induction of LTP/LTD reflects the actual (local) synaptic state. The model and the results suggest a physiologically plausible explanation of why LTD induction is experimentally difficult, and they offer experimentally testable predictions on the stimulation protocols that may be more effective.
Migliore M, De Simone G, Migliore R (2015) Effect of the initial synaptic state on the probability to induce long-term potentiation and depression.
(Click on a link to find other models with that property)
Hippocampus CA1 pyramidal GLU cell;
Long-term Synaptic Plasticity;
Migliore, Michele [Michele.Migliore at Yale.edu];
Migliore, Rosanna [rosanna.migliore at cnr.it];
for information about:
Hippocampus CA1 pyramidal GLU cell
File not selected
<- Select file from this column.
Loading data, please wait...