Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)

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Neocortical Layer V model with firing behaviour adjusted to in vitro observations. The model was used to investigate the effects of IFN and PKC on the excitability of neurons (Stadler et al 2014, Reetz et al. 2014). The model contains new channel simulations for HCN1, HCN2 and the big calcium dependent potassium channel BK.
1 . Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Bräuer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U (2014) Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations. Cereb Cortex 24:199-210 [PubMed]
2 . Reetz O, Stadler K, Strauss U (2014) Protein kinase C activation mediates interferon-ß-induced neuronal excitability changes in neocortical pyramidal neurons. J Neuroinflammation 11:185 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Mixed; I Potassium; I Q;
Gap Junctions:
Gene(s): HCN1; HCN2;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models; Action Potentials; Signaling pathways;
Implementer(s): Stadler, Konstantin [konstantin.stadler at];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Mixed; I Potassium; I Q;
TITLE HCN2 with one time constant
: Konstantin Stadler 2009
	(mA) = (milliamp)
	(mV) = (millivolt)


    	v 		(mV)		
    	Vrev  = -40	(mV)
    	gpeak = 0.00015	(mho/cm2) <0, 1e9>
    	vhakt = -93.6		(mV)
    	k     = -11.9		(mV)
    	vhtau = -84.6		(mV)
    	a0t   = 0.00372		(/ms)
    	zetat = 1.5		(/mV)
    	gmt   = .561	(1)
    	celsius		(degC)			
    	temp  = 23	(degC)
    	q10   = 4.5		(1)
    	qtl   = 1		(1)

	SUFFIX hcn2
    	RANGE gpeak, vhakt		


	i (mA/cm2)
    	linf (1)     
    	taul (ms)
    	ghd (mho/cm2)


	SOLVE states METHOD cnexp
	ghd = gpeak*l	
	i = ghd*(v-Vrev)			


FUNCTION alpt(v(mV)) (1) {	
  alpt = exp(0.0378*zetat*(v-vhtau)) 

FUNCTION bett(v(mV)) (1) {	
  bett = exp(0.0378*zetat*gmt*(v-vhtau)) 

DERIVATIVE states {     
        l' =  (linf - l)/taul

PROCEDURE rate(v (mV)) {
        LOCAL a,b,qt
        a = alpt(v)			:a und b fuer tau
        b = bett(v)
        linf = 1/(1 + exp(-(v-vhakt)/k))	
        taul = b/(qtl*qt*a0t*(1+a))		

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