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Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
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Accession:
168414
" ... To study the mechanisms underlying SCS (Spinal cord stimulation), we constructed a biophysically-based network model of the dorsal horn circuit consisting of interconnected dorsal horn interneurons and a wide dynamic range (WDR) projection neuron and representations of both local and surround receptive field inhibition. We validated the network model by reproducing cellular and network responses relevant to pain processing including wind-up, A-fiber mediated inhibition, and surround receptive field inhibition. ..." See paper for more.
Reference:
1 .
Zhang TC, Janik JJ, Grill WM (2014) Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition.
J Neurophysiol
112
:552-67
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Wide dynamic range neuron;
Channel(s):
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Glutamate;
Glycine;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Implementer(s):
Zhang, Tianhe [tz5@duke.edu];
Search NeuronDB
for information about:
GabaA
;
AMPA
;
NMDA
;
Glutamate
;
Glycine
;
Download the displayed file
/
ZhangEtAl2014
Foreman SCS
CellTemplates.hoc
*
Other models using CellTemplates.hoc:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
CellTempList.dat
*
Other models using CellTempList.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
CellTypeVector.txt
*
Other models using CellTypeVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
CellVector.txt
*
Other models using CellVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Connectivities_Surround_ERev_70.xls
Coordinates_Trial.xlsx
*
Other models using Coordinates_Trial.xlsx:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
DelayVector.txt
*
Other models using DelayVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
ERevVector.txt
EX_Cell_filenames.dat
*
Other models using EX_Cell_filenames.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
EX_Cell_filenamesH.dat
*
Other models using EX_Cell_filenamesH.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
EX_Cell_filenamesM.dat
*
Other models using EX_Cell_filenamesM.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
EX_Cell_SynapseID.dat
*
Other models using EX_Cell_SynapseID.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
EX_Cell_Synapses_OneEX_Zone2_SCS.txt
*
Other models using EX_Cell_Synapses_OneEX_Zone2_SCS.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
FromVector.txt
*
Other models using FromVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
MakeNetwork.hoc
*
Other models using MakeNetwork.hoc:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
MATLAB_Afferent_Spikes_Foreman.mat
MATLAB_Afferent_Spikes_Foreman_Grouped.mat
nrnmech.dll
*
Other models using nrnmech.dll:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
RunSim_Foreman.hoc
S_NetStim_SynapseID.dat
*
Other models using S_NetStim_SynapseID.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SG_Cell_filenames.dat
*
Other models using SG_Cell_filenames.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SG_Cell_filenamesH.dat
*
Other models using SG_Cell_filenamesH.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SG_Cell_filenamesM.dat
*
Other models using SG_Cell_filenamesM.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SG_Cell_Pair_1_Vm.png
*
Other models using SG_Cell_Pair_1_Vm.png:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SG_Cell_SynapseID.dat
*
Other models using SG_Cell_SynapseID.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SG_Cell_Synapses_OneEX_Multiconn_Glycine.dat
*
Other models using SG_Cell_Synapses_OneEX_Multiconn_Glycine.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SG_Cell_Synapses_OneEX_Zone2_SCS.txt
*
Other models using SG_Cell_Synapses_OneEX_Zone2_SCS.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SGSCS_Cell_filenames.dat
*
Other models using SGSCS_Cell_filenames.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SGSCS_Cell_filenamesH.dat
*
Other models using SGSCS_Cell_filenamesH.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SGSCS_Cell_filenamesM.dat
*
Other models using SGSCS_Cell_filenamesM.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SGSCS_Cell_SynapseID.dat
*
Other models using SGSCS_Cell_SynapseID.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SGSCS_Cell_Synapses_OneEX_Zone2_SCS.txt
*
Other models using SGSCS_Cell_Synapses_OneEX_Zone2_SCS.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
SGZ2_Cell_Synapses_OneEX_Zone2_SCS.txt
*
Other models using SGZ2_Cell_Synapses_OneEX_Zone2_SCS.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Shell.hoc
SpikeStatsVector.txt
SpikeTimesVector.txt
SynapseVector.txt
*
Other models using SynapseVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
T_Cell_filenames.dat
*
Other models using T_Cell_filenames.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
T_Cell_filenamesH.dat
*
Other models using T_Cell_filenamesH.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
T_Cell_filenamesM.dat
*
Other models using T_Cell_filenamesM.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
T_Cell_SpikeCount.png
*
Other models using T_Cell_SpikeCount.png:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
T_Cell_SynapseID.dat
*
Other models using T_Cell_SynapseID.dat:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
T_Cell_Synapses_OneEX_Zone2_SCS.txt
*
Other models using T_Cell_Synapses_OneEX_Zone2_SCS.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
ThresholdVector.txt
*
Other models using ThresholdVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
ToVector.txt
*
Other models using ToVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
WeightVector.txt
XVector.txt
*
Other models using XVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
YVector.txt
*
Other models using YVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
ZVector.txt
*
Other models using ZVector.txt:
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)
15.000 -1000000000000000.000
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WindUp
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