Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)

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Accession:168414
" ... To study the mechanisms underlying SCS (Spinal cord stimulation), we constructed a biophysically-based network model of the dorsal horn circuit consisting of interconnected dorsal horn interneurons and a wide dynamic range (WDR) projection neuron and representations of both local and surround receptive field inhibition. We validated the network model by reproducing cellular and network responses relevant to pain processing including wind-up, A-fiber mediated inhibition, and surround receptive field inhibition. ..." See paper for more.
Reference:
1 . Zhang TC, Janik JJ, Grill WM (2014) Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition. J Neurophysiol 112:552-67 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Wide dynamic range neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Glutamate; Glycine;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Zhang, Tianhe [tz5@duke.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Glutamate; Glycine;
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ZhangEtAl2014
WindUp
CellTemplates.hoc *
CellTempList.dat *
CellTypeVector.txt *
CellVector.txt *
Connectivities_NoSurround_ERev_70.xls
Coordinates_Trial.xlsx *
DelayVector.txt *
EX_Cell_filenames.dat *
EX_Cell_filenamesH.dat *
EX_Cell_filenamesM.dat *
EX_Cell_SynapseID.dat *
EX_Cell_Synapses_OneEX_Zone2_SCS.txt *
FromVector.txt *
MakeNetwork.hoc *
MATLAB_Afferent_Spikes_WindUp.mat
MATLAB_Afferent_Spikes_WindUp_Grouped.mat
nrniv.exe.stackdump
nrnmech.dll *
RunSim_WindUp.hoc
S_NetStim_SynapseID.dat *
SG_Cell_filenames.dat *
SG_Cell_filenamesH.dat *
SG_Cell_filenamesM.dat *
SG_Cell_Pair_1_Vm.png *
SG_Cell_SynapseID.dat *
SG_Cell_Synapses_OneEX_Multiconn_Glycine.dat *
SG_Cell_Synapses_OneEX_Zone2_SCS.txt *
SGSCS_Cell_filenames.dat *
SGSCS_Cell_filenamesH.dat *
SGSCS_Cell_filenamesM.dat *
SGSCS_Cell_SynapseID.dat *
SGSCS_Cell_Synapses_OneEX_Zone2_SCS.txt *
SGZ2_Cell_Synapses_OneEX_Zone2_SCS.txt *
Shell_NoSurround.hoc
SpikeStatsVector.txt
SpikeTimesVector.txt
SynapseVector.txt *
T_Cell_filenames.dat *
T_Cell_filenamesH.dat *
T_Cell_filenamesM.dat *
T_Cell_SpikeCount.png *
T_Cell_SynapseID.dat *
T_Cell_Synapses_Glycine.txt
T_Cell_Synapses_OneEX_Zone2_SCS.txt *
ThresholdVector.txt *
ToVector.txt *
WeightVector.txt
XVector.txt *
YVector.txt *
ZVector.txt *
                            
Stack trace:
Frame     Function  Args
0028BFE4  767F1194  (00000170, 0000EA60, 00000000, 0028C118)
0028BFF8  767F1148  (00000170, 0000EA60, 000000A4, 0028C040)
0028C118  61097F54  (00000000, 00000174, 0028C138, 000000A4)
0028C208  61095AEB  (00000000, 0053002B, 002B002B, 0028CE68)
0028C268  61095FCB  (0028C280, 00000000, 00000094, 610253F0)
0028C328  61096182  (00000EF0, 00000006, 0028C358, 61096383)
0028C338  610961AC  (00000006, 0028CE88, 00720069, 00630065)
0028C358  61096383  (00750070, 00610074, 00690074, 006E006F)
Exception: STATUS_ACCESS_VIOLATION at eip=61016583
eax=610C5967 ebx=61108148 ecx=00000000 edx=00000284 esi=00000008 edi=00000001
ebp=00A6C898 esp=00A6C890 program=c:\nrn71\bin\nrniv.exe, pid 3824, thread sig
cs=0023 ds=002B es=002B fs=0053 gs=002B ss=002B
Stack trace:
Frame     Function  Args
00A6C898  61016583  (61108148, 6111C19B, 006E006F, 00000000)
00A6C8B8  610166EC  (00000001, 00000000, 00000000, 00A6C940)
00A6C8F8  61017FD5  (00000060, 00A6C940, 00000000, 00000000)
00A6CC38  61018638  (00000118, 00A6CC70, 000000A4, 00A6CC6C)
00A6CD38  61099F57  (61106F00, 00000000, 00000000, 00000000)
00A6CD68  61002F32  (00A6CE64, 61018970, 00001074, 00000000)
61003650  61003769  (04A16430, 89000000, FFDA90B0, 24468BFF)
 113433 [sig] nrniv 3824 _cygtls::handle_exceptions: Error while dumping state (probably corrupted stack)
30601997 [main] nrniv 3824 sig_send: wait for sig_complete event failed, signal 6, rc 258, Win32 error 0

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