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Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
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Model Information
Model File
Citations
Accession:
169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 .
Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum.
J Neurosci
35
:1149-59
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Neuron or other electrically excitable cell;
Axon;
Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Neostriatum medium spiny indirect pathway GABA cell;
Neostriatum fast spiking interneuron;
Channel(s):
I Sodium;
I Potassium;
Kir;
Gap Junctions:
Gap junctions;
Receptor(s):
D1;
D2;
GabaA;
Glutamate;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
GENESIS;
Model Concept(s):
Synchronization;
Detailed Neuronal Models;
Parkinson's;
Implementer(s):
Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
Neostriatum medium spiny indirect pathway GABA cell
;
D1
;
D2
;
GabaA
;
Glutamate
;
I Sodium
;
I Potassium
;
Kir
;
Gaba
;
Glutamate
;
/
DamodaranEtAl2015
MScell
channels
ampa_channel.g
*
Other models using ampa_channel.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
BKKchannel.g
*
Other models using BKKchannel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
CaL12inact_channel.g
*
Other models using CaL12inact_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
CaL13_channel.g
*
Other models using CaL13_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
CaNinact_channel.g
*
Other models using CaNinact_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
CaR_channel.g
*
Other models using CaR_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
CaT_channel.g
*
Other models using CaT_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
gaba_channel.g
K_DR_channel.g
*
Other models using K_DR_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
kAf_chanRE.g
*
Other models using kAf_chanRE.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
kAs_chanRE.g
*
Other models using kAs_chanRE.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
kIR_chanKD.g
*
Other models using kIR_chanKD.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
naF_chanOg.g
*
Other models using naF_chanOg.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
nmda_channel.g
*
Other models using nmda_channel.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
SKchannelCaDep.g
*
Other models using SKchannelCaDep.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
synaptic_channel.g
*
Other models using synaptic_channel.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
tabchanforms.g
*
Other models using tabchanforms.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
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