//genesis
/*************************** MS Model, Version 5.2 *********************
**************************** CaNNOINACT_channel.g *********************
Tom Sheehan tsheeha2@gmu.edu thsheeha@vt.edu 703-538-8361
******************************************************************************
******************************************************************************/
function create_CaNNOINACT
str chanName = "CaNNOINACT_channel"
str compPath = "/library"
int c = 0
float increment = 0.00005
float x = -0.1
int xdivs = 3000
float xmin = -0.1
float xmax = 0.05
float mPower = 1.0
float hPower = 0.0
float mvHalfCaN = -8.7e-3
float mkCaN = -7.4e-3
float mTauCaNNOINACT = 0.0
float mInfCaNNOINACT = 0.0
float theta = 0.0
float beta = 0.0
float beta_exp = 0.0
float mA = 0.0
float mB = 0.0
float surf = 0.0
int qFactCaN = {3.0/{CaSlow}}
float gMax = 7.9e-008
pushe {compPath}
create tabchannel {chanName}
setfield {chanName} Xpower {mPower} Ypower {hPower}
call {chanName} TABCREATE X {xdivs} {xmin} {xmax}
for(c = 0; c < {xdivs} + 1; c = c + 1)
/****************** Begin CaNNOINACT_mTau ********************/
// mA = 0.03856e6*(vMemb + 17.19e-3)./
// (exp((vMemb + 17.19e-3)/15.22e-3)-1);
// mB = 0.3842e3*exp(vMemb/23.82e-3);
// mTauCaN = (1./(mA + mB)) / qFactCaN;
theta = 0.03856e6*{ {x} + 17.19e-3}
beta = {{x} + 17.19e-3}/15.22e-3
beta_exp = {exp {beta}}
beta_exp = beta_exp - 1.0
mA = {{theta}/{beta_exp}}
beta = {{x}/23.82e-3}
beta_exp = {exp {beta}}
mB = 0.3842e3*{beta_exp}
mTauCaNNOINACT = {1/{mA + mB}}/{qFactCaN}
setfield {chanName} X_A->table[{c}] {mTauCaNNOINACT}
/***************** End CaNNOINACT_mTau ***********************/
/***************** Begin CaNNOINACT_mInf *********************/
// mInfCaN = 1./(1 + exp((vMemb - mvHalfCaN)/mkCaN));
beta = {{x} - {mvHalfCaN}}/{mkCaN}
beta_exp = {exp {beta}} + 1.0
mInfCaNNOINACT = 1.0/{beta_exp}
setfield {chanName} X_B->table[{c}] {mInfCaNNOINACT}
/***************** End CaNNOINACT_mInf ***********************/
x = x + increment
end
tweaktau {chanName} X
create ghk {chanName}GHK
setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM,
// Wolf 5mM
setfield {chanName}GHK valency 2.0
setfield {chanName}GHK T {TEMPERATURE}
setfield {chanName} Gbar {gMax*surf}
addmsg {chanName} {chanName}GHK PERMEABILITY Gk
pope
end
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