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Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
AddSynapticChannels.g *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.p *
FScellSyn.g *
include_channels.g *
proto.g *
SynParams.g *

/***************************		MS Model, Version 5.12	**********************
**************************** 	     SynapticChannels.g 	**********************
Tom Sheehan	703-538-8361

function addSynChannel (compPath, chanpath, gbar)

  str compPath, chanpath
  float gbar

  copy /library/{chanpath} {compPath}/{chanpath}

  addmsg {compPath} {compPath}/{chanpath} VOLTAGE Vm
  addmsg {compPath}/{chanpath} {compPath} CHANNEL Gk Ek

  // Set the new conductance
  float len = {getfield {compPath} len}
  float dia = {getfield {compPath} dia}
  float pi = 3.141592653589793
  float surf = {len*dia*pi}

	echo "compPath = "{compPath}
	echo "chanpath = "{chanpath}
	echo "gbar = "{gbar}

//  setfield {compPath}/{chanName} gmax {surf*gbar}
  setfield {compPath}/{chanpath} gmax {gbar}

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