This is an ODE model of autocrine/paracrine microglial cytokine interactions. Simulations include analyses of neuroinflammation mechanisms in the context of adaptation and tolerance to LPS.
Reference:
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Anderson WD, Makadia HK, Greenhalgh AD, Schwaber JS, David S, Vadigepalli R (2015) Computational modeling of cytokine signaling in microglia. Mol Biosyst 11:3332-46 [PubMed]
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