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Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
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Accession:
17664
We adopted De Schutter and Bower's model as the starting point, then modified the descriptions of several ion channels, such as the P-type Ca channel and the delayed rectifier K channel, and added class-E Ca channels and D-type K channels to the model. Our new model reproduces most of our experimental results and supports the conclusions of our experimental study that class-E Ca channels and D-type K channels are present and functioning in the dendrites of Purkinje neurons.
Reference:
1 .
Miyasho T, Takagi H, Suzuki H, Watanabe S, Inoue M, Kudo Y, Miyakawa H (2001) Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study.
Brain Res
891
:106-15
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Cerebellum Purkinje GABA cell;
Channel(s):
I Na,p;
I Na,t;
I T low threshold;
I A;
I K;
I M;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
I A, slow;
I_KD;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Activity Patterns;
Dendritic Action Potentials;
Bursting;
Active Dendrites;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Action Potentials;
Calcium dynamics;
Implementer(s):
Miyakawa, H [Miyakawa at ls.toyaku.ac.jp];
Search NeuronDB
for information about:
Cerebellum Purkinje GABA cell
;
I Na,p
;
I Na,t
;
I T low threshold
;
I A
;
I K
;
I M
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
I A, slow
;
I_KD
;
Download the displayed file
/
prknj
readme
CaE.mod
*
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CalciumP.mod
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CaP.mod
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CaP2.mod
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CaT.mod
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K2.mod
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K22.mod
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K23.mod
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KA.mod
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KC.mod
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KC2.mod
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KC3.mod
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KD.mod
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Kdr.mod
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Kh.mod
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Khh.mod
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KM.mod
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Leak.mod
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NaF.mod
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NaP.mod
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mosinit.hoc
purkinje.hoc
purkinje.ses
load_file("nrngui.hoc") load_file("purkinje.hoc") load_file("purkinje.ses") run()
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