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Layer 5 Pyramidal Neuron (Shai et al., 2015)
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Accession:
180373
This work contains a NEURON model for a layer 5 pyramidal neuron (based on Hay et al., 2011) with distributed groups of synapses across the basal and tuft dendrites. The results of that simulation are used to fit a phenomenological model, which is also included in this file.
Reference:
1 .
Shai AS, Anastassiou CA, Larkum ME, Koch C (2015) Physiology of layer 5 pyramidal neurons in mouse primary visual cortex: coincidence detection through bursting.
PLoS Comput Biol
11
:e1004090
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
MATLAB;
Model Concept(s):
Dendritic Action Potentials;
Active Dendrites;
Implementer(s):
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Glutamate
;
/
ShaiEtAl2015
morphologies
cell1.asc
*
Other models using cell1.asc:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Effect of ionic diffusion on extracellular potentials (Halnes et al 2016)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
cell2.asc
*
Other models using cell2.asc:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
cell3.asc
*
Other models using cell3.asc:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
V1.ASC
*
Other models using V1.ASC:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
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