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Application of a common kinetic formalism for synaptic models (Destexhe et al 1994)
 
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Accession:
18198
Application to AMPA, NMDA, GABAA, and GABAB receptors is given in a book chapter. The reference paper synthesizes a comprehensive general description of synaptic transmission with Markov kinetic models. This framework is applicable to modeling ion channels, synaptic release, and all receptors. Please see the references for more details. A simple introduction to this method is given in a seperate paper Destexhe et al Neural Comput 6:14-18 , 1994). More information and papers at http://cns.iaf.cnrs-gif.fr/Main.html and through email: Destexhe@iaf.cnrs-gif.fr
References:
1 .
Destexhe A, Mainen ZF, Sejnowski TJ (1994) Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.
J Comput Neurosci
1
:195-230
[
PubMed
]
2 .
Destexhe A, Mainen Z, Sejnowski TJ (1994) An efficient method for computing synaptic conductances based on a kinetic model of receptor binding
Neural Comput
6
:14-18
3 .
Destexhe A, Mainen Z, Sejnowski T (1995) Fast Kinetic Models for Simulating AMPA, NMDA, GABAA and GABAB Receptors
The Neurobiology of Computation
, Bower J, ed. pp.9
Model Information
(Click on a link to find other models with that property)
Model Type:
Synapse;
Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Nicotinic;
M1;
M3;
M4;
M5;
M2;
mGluR1;
mGluR2;
mGluR3;
mGluR4;
mGluR5;
mGluR6;
mGluR7;
mGluR8;
Alpha;
Alpha1;
Alpha2;
Beta;
D1;
D2;
5-HT1;
5-HT2;
5-HT4;
H2;
GabaA;
GabaB;
Muscarinic;
AMPA;
NMDA;
mGluR;
5-HT3;
Kainate;
Monoamine Receptors;
Glutamate;
Gaba;
Adrenergic;
Serotonin;
Histamine;
Cholinergic Receptors;
Amino Acid Receptors;
Sensory Receptors;
Olfactory Receptors;
Opsins;
Dopaminergic Receptor;
Glycine;
Gaseous Receptors;
NO;
Peptide Receptors;
Dynorphin;
H1;
Ion Receptors;
Zn2+;
CO;
Gene(s):
Transmitter(s):
Acetylcholine;
Glycine;
Dopamine;
Zn2+;
NO;
CO;
Dynorphin;
Ephinephrine;
Norephinephrine;
Amino Acids;
Gaba;
Glutamate;
Monoamines;
Peptides;
Ions;
Gases;
Histamine;
Serotonin;
Simulation Environment:
NEURON;
Model Concept(s):
Ion Channel Kinetics;
Markov-type model;
Implementer(s):
Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Mainen, Zach [Mainen at cshl.edu];
Search NeuronDB
for information about:
Nicotinic
;
M1
;
M3
;
M4
;
M5
;
M2
;
mGluR1
;
mGluR2
;
mGluR3
;
mGluR4
;
mGluR5
;
mGluR6
;
mGluR7
;
mGluR8
;
Alpha
;
Alpha1
;
Alpha2
;
Beta
;
D1
;
D2
;
5-HT1
;
5-HT2
;
5-HT4
;
H2
;
GabaA
;
GabaB
;
Muscarinic
;
AMPA
;
NMDA
;
mGluR
;
5-HT3
;
Kainate
;
Monoamine Receptors
;
Glutamate
;
Gaba
;
Adrenergic
;
Serotonin
;
Histamine
;
Cholinergic Receptors
;
Amino Acid Receptors
;
Sensory Receptors
;
Olfactory Receptors
;
Opsins
;
Dopaminergic Receptor
;
Glycine
;
Gaseous Receptors
;
NO
;
Peptide Receptors
;
Dynorphin
;
H1
;
Ion Receptors
;
Zn2+
;
CO
;
Acetylcholine
;
Glycine
;
Dopamine
;
Zn2+
;
NO
;
CO
;
Dynorphin
;
Ephinephrine
;
Norephinephrine
;
Amino Acids
;
Gaba
;
Glutamate
;
Monoamines
;
Peptides
;
Ions
;
Gases
;
Histamine
;
Serotonin
;
/
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AMPA - detailed
AMPA - simple
GABA_A - detailed
GABA_A - simple
GABA_B - detailed
GABA_B - simple
NMDA - detailed
NMDA - simple
Synaptic Release
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