CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)

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Accession:184054
This model simulates the effects of dendritic sodium spikes initiated in distal apical dendrites on the voltage and the calcium dynamics revealed by calcium imaging. It shows that dendritic sodium spike promotes large and transient calcium influxes via NMDA receptor and L-type voltage-gated calcium channels, which contribute to the induction of LTP at distal synapses.
Reference:
1 . Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. Elife [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I L high threshold; I K; Ca pump; I Sodium;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Synaptic Plasticity; Long-term Synaptic Plasticity; Synaptic Integration; Calcium dynamics; Conductance distributions;
Implementer(s): Cembrowski, Mark S [cembrowskim at janelia.hhmi.org]; Hsu, Ching-Lung [hsuc at janelia.hhmi.org];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I L high threshold; I K; I Sodium; Ca pump; Glutamate;
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fullMorphCaLTP8
fullMorphCaLTP8
calH.mod
cdp.mod
id.mod
kad.mod *
kap.mod *
kdr.mod *
na3.mod *
nmdaSyn.mod
spgen2.mod
analyseTBSCC.hoc
channelParameters.hoc
displayPanels.hoc
doTBSStimCC.hoc
getVoltageIntegral.hoc
init.hoc
initializationAndRun.hoc
morphology_ri06.nrn *
naceaxon.nrn *
plotTBSCC.hoc
preallocate.hoc
resetNSeg.hoc *
runTBSCC.hoc
seclists.hoc
start.hoc
                            
TITLE Ca L-type channel with high treshold of activation
: inserted in distal dendrites to account for distally
: restricted initiation of Ca++ spikes
: uses channel conductance (not permeability)
: written by Yiota Poirazi, 1/8/00 poirazi@LNC.usc.edu

NEURON {
	SUFFIX calH
	USEION ca READ eca WRITE ica
        RANGE gcalbar, m, h, ica
	RANGE inf, fac, tau
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {          : parameters that can be entered when function is called in cell-setup
        v               (mV)
        celsius = 34	(degC)
	dt              (ms)
        gcalbar = 0     (mho/cm2) : initialized conductance
	eca = 140       (mV)      : Ca++ reversal potential
        }

STATE {	m h }                     : unknown activation and inactivation parameters to be solved in the DEs  

ASSIGNED {                        : parameters needed to solve DE
	ica (mA/cm2)
        inf[2]
	fac[2]
	tau[2]
}

BREAKPOINT {
	SOLVE states
	ica = gcalbar*m*m*m*h*(v - eca)       
	}

INITIAL {
        m = 0    : initial activation parameter value
	h = 1    : initial inactivation parameter value
        states()
	ica = gcalbar*m*m*m*h*(v - eca) : initial Ca++ current value
     	}

PROCEDURE calcg() {
	mhn(v*1(/mV))
	m = m + fac[0]*(inf[0] - m)
	h = h + fac[1]*(inf[1] - h)
	}	

PROCEDURE states() {	: exact when v held constant
	calcg()
	VERBATIM
	return 0;
	ENDVERBATIM
}

FUNCTION varss(v, i) {
	if (i==0) { 
             varss = 1 / (1 + exp((v+37)/(-1)))  : Ca activation 
	}
	else if (i==1) { 
             varss = 1 / (1 + exp((v+41)/(0.5))) : Ca inactivation 
	}
}

FUNCTION vartau(v, i) {
	if (i==0) {
           vartau = 3.6  : activation variable time constant
        }
	else if (i==1) {
:           vartau = 25   : inactivation variable time constant
           vartau = 29   : inactivation variable time constant
        }
}	

PROCEDURE mhn(v) {LOCAL a, b :rest = -70
:      TABLE inf, fac DEPEND dt, celsius FROM -100 TO 100 WITH 200
	FROM i=0 TO 1 {
		tau[i] = vartau(v,i)
		inf[i] = varss(v,i)
		fac[i] = (1 - exp(-dt/tau[i]))
	}
}


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