CA3 pyramidal neurons: Kv1.2 mediates modulation of cortical inputs (Hyun et al., 2015)

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Accession:184139
This model simulates the contribution of dendritic Na+ and D-type K+ channels to EPSPs at three different locations of apical dendrites, which mimicking innervation sites of mossy fibers (MF), recurrent fibers (AC), and perforant pathway (PP).
Reference:
1 . Hyun JH, Eom K, Lee KH, Bae JY, Bae YC, Kim MH, Kim S, Ho WK, Lee SH (2015) Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. J Physiol 593:3617-43 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I A; I Sodium; I_KD;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; I A; I Sodium; I_KD;
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HyunEtAl2015
ReadMe.html
Exp2GluSyn.mod
KaProx.mod
KdBG40.mod
Kdr.mod
KhdM01.mod
Na.mod
E807.hoc
Fig7Bb_(IK_conditioned).hoc
Fig7Bb_(IK_control).hoc
Fig7Bc(Gin).hoc
Fig7C_(AC-EPSP).hoc
Fig7C_(MF-EPSP).hoc
Fig7C_(PP-EPSP).hoc
Fig7D_(AC-EPSP).hoc
Fig7D_(MF-EPSP).hoc
Fig7D_(PP-EPSP).hoc
Fig7E_(control).hoc
Fig7E_(lowGkd).hoc
Fig7E_(lowGkdlowGna).hoc
fixnseg.hoc *
L22.hoc
mosinit.hoc
screenshot.png
                            
TITLE I-h channel from Magee 1998 for distal dendrites

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v 		(mV)
    ehd  		(mV)        
	celsius 	(degC)
	ghdbar=.0001 	(mho/cm2)
    vhalfl=-90   	(mV)
    vhalft=-75   	(mV)
    a0t=0.011      	(/ms)
    zetal=4    	(1)
    zetat=2.2   (1)
    gmt=.4   	(1)
	q10=4.5
	qtl=1
}


NEURON {
	SUFFIX KhdM01
	NONSPECIFIC_CURRENT i
    RANGE ghdbar, vhalfl
    GLOBAL linf,taul
}

STATE {
    l
}

ASSIGNED {
	i (mA/cm2)
    linf      
    taul
    gbar
}

INITIAL {
	rate(v)
	l=linf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	gbar = ghdbar*l
	i = gbar*(v-ehd)
}


FUNCTION alpl(v(mV)) {
  alpl = exp(1.e-3*zetal*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION alpt(v(mV)) {
  alpt = exp(1.e-3*zetat*(v-vhalft)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION bett(v(mV)) {
  bett = exp(1.e-3*zetat*gmt*(v-vhalft)*9.648e4/(8.315*(273.16+celsius))) 
}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rate(v)
        l' =  (linf - l)/taul
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-33)/10)
        a = alpt(v)
        linf = 1/(1+ alpl(v))
        taul = bett(v)/(qtl*qt*a0t*(1+a))
}

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