Cortico-striatal plasticity in medium spiny neurons (Gurney et al 2015)

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Accession:184175
In the associated paper (Gurney et al, PLoS Biology, 2015) we presented a computational framework that addresses several issues in cortico-striatal plasticity including spike timing, reward timing, dopamine level, and dopamine receptor type. Thus, we derived a complete model of dopamine and spike-timing dependent cortico-striatal plasticity from in vitro data. We then showed this model produces the predicted activity changes necessary for learning and extinction in an operant task. Moreover, we showed the complex dependencies of cortico-striatal plasticity are not only sufficient but necessary for learning and extinction. The model was validated in a wider setting of action selection in basal ganglia, showing how it could account for behavioural data describing extinction, renewal, and reacquisition, and replicate in vitro experimental data on cortico-striatal plasticity. The code supplied here allows reproduction of the proposed process of learning in medium spiny neurons, giving the results of Figure 7 of the paper.
Reference:
1 . Gurney KN, Humphries MD, Redgrave P (2015) A new framework for cortico-striatal plasticity: behavioural theory meets in vitro data at the reinforcement-action interface. PLoS Biol 13:e1002034 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum spiny neuron; Abstract Izhikevich neuron;
Channel(s):
Gap Junctions:
Receptor(s): D1; D2;
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: MATLAB;
Model Concept(s): Synaptic Plasticity; Learning; Reinforcement Learning; STDP; Reward-modulated STDP;
Implementer(s): Gurney, Kevin [K.Gurney at shef.ac.uk];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; Dopamine;
 
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