dendrites of neocortical pyramidal neurons, calcium spikes are known
to contribute to burst generation, but a comparable understanding of
basal dendritic mechanisms is lacking. Here we show that NMDA spikes
in basal dendrites mediate both detection and generation of bursts
through a postsynaptic mechanism.
High-frequency inputs to basal
dendrites markedly facilitated NMDA spike initiation compared with
low-frequency activation or single inputs.
Polsky A, Mel B, Schiller J (2009) Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. J Neurosci 29:11891-903 [PubMed]