" ... Based on
experimental observations, we developed a computational model that can
be embedded in more comprehensive models of respiratory and
cardiovascular autonomic control. Our simulation results successfully
reproduce the variability we observed experimentally. The in silico
model suggests that age-dependent variability may be due to a
developmental increase in mean synaptic conductance between preBötC
neurons. We also used simulations to explore the effects of stochastic
spiking in sensory relay neurons. Our results suggest that stochastic
spiking may actually stabilize modulation of both respiratory rate and
its variability when the rate changes due to physiological demand.
"
Reference:
1 .
Fietkiewicz C, Shafer GO, Platt EA, Wilson CG (2016) Variability in respiratory rhythm generation: In vitro and in silico models Communications in Nonlinear Science and Numerical Simulation 32:158-168
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