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Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
 
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Accession:
187615
Python and MATLAB scripts for studying the dual effects of SCZ-related genes on layer 5 pyramidal cell firing and sinoatrial node cell pacemaking properties. The study is based on two L5PC models (Hay et al. 2011, Almog & Korngreen 2014) and SANC models (Kharche et al. 2011, Severi et al. 2012).
Reference:
1 .
Mäki-Marttunen T, Lines GT, Edwards AG, Tveito A, Dale AM, Einevoll GT, Andreassen OA (2017) Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.
Transl Psychiatry
7
:5
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Cardiac atrial cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
I A, slow;
Na/Ca exchanger;
I_SERCA;
Na/K pump;
Kir;
Gap Junctions:
Receptor(s):
Gene(s):
Nav1.1 SCN1A;
Cav3.3 CACNA1I;
Cav1.3 CACNA1D;
Cav1.2 CACNA1C;
Transmitter(s):
Simulation Environment:
NEURON;
MATLAB;
Python;
Model Concept(s):
Schizophrenia;
Implementer(s):
Maki-Marttunen, Tuomo [tuomomm at uio.no];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
I A, slow
;
Na/Ca exchanger
;
I_SERCA
;
Na/K pump
;
Kir
;
/
pleiotropy
hay
models
L5PCbiophys3.hoc
*
Other models using L5PCbiophys3.hoc:
Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017)
Effect of ionic diffusion on extracellular potentials (Halnes et al 2016)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
L5PCtemplate.hoc
*
Other models using L5PCtemplate.hoc:
Effect of ionic diffusion on extracellular potentials (Halnes et al 2016)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
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