Striatal Spiny Projection Neuron (SPN) plasticity rule (Jedrzejewska-Szmek et al 2016)

 Download zip file 
Help downloading and running models
Accession:189153

Reference:
1 . Jedrzejewska-Szmek J, Damodaran S, Dorman DB, Blackwell KT (2017) Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons. Eur J Neurosci 45:1044-1056 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Synaptic Plasticity;
Implementer(s): Jedrzejewska-Szmek, Joanna ; Damodaran, Sriraman ; Dorman, Daniel B ; Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Glutamate;
//genesis 
//Fino.g 

//Pre-synaptic parameters
str prestim = 2
float pulseFreq = 50
int pulses = 1

//Post-synaptic parameters
float inject=0.47e-9 //1e-9
float burstFreq = 1 
int numbursts = 1
float trainFreq=1
int numtrains=100
AP_durtime=0.030 
float APinterval={1.0/10.0}
int numAP=1
if ({GABAtonic})
    inject=1.e-9//1.3675e-9
    echo {inject}
end

if ({Timing}=="Pre")
    float ISI = -0.010
    if ({GABAYesNo})
        float ISI = 0.04
    end
    if ({GABAtonic})
        float ISI = 0.04
    end
elif ({Timing}=="Post")
    float ISI = -0.040
end

Loading data, please wait...