//genesis
//SynParamsCtx.g
str AMPAname = "AMPA"
float EkAMPA = 0.0
float AMPAtau1 = 1.1e-3 //wolf with qfact of 2 taken into account (t1 and t2)
//float AMPAtau2 = 5.75e-3 //these tau are quite slow compared to hippocampal values
//float AMPAgmax = 0.51e-9 // 45 mV PSP, AP calcium trivial compared to PSP
//float AMPAtau1=0.2e-3
float AMPAtau2=2.0e-3 // double hippo values; faster than GABA
float AMPAgmax=0.125e-9 //0.15 0.19 25 mV PSP, AP calcium higher than PSP calcium 0.342e-9
float AMPACaper = 0.00 //0.001 //percent AMPA conductance that is carried by calcium. value from wolf //more like 2/1 for thalamus so should be 0.47e-9 for thalamo-striatal syanpnse if NMDA is 0.94e-9 Rebekah Evans 6/25/10
float AMPAdes = 1 // 1 //desensitization factor, (depr_per_spike field of facsynchan)
float AMPAdestau = 100e-3 // 100e-3 // desensitization tau (how fast des recovers)
float depr = 1
float deprtau = 100e-3
str GABAname = "GABA"
float GABAtau1 = 0.25e-3 // From Galarreta and Hestrin 1997
float GABAtau2 = 80.75e-3 //(used in Wolfs model)
float EkGABA = -0.060 //calculated Kerr and Plenz 2004 Erev for Cl, is -60 mV 5/2/12 RCE
float GABAgmax = 5000e-12 //was 750, Sri uses 900 //Modified Koos 2004 (Wolf uses 435e-12)//5000 if GABAtau2 is 75 ms (NPY neurons)
//10000e-12 if GABAtau2 is 3.75ms
float GABAdelay = 0.015
int ghk_yesno=1 //0 no ghk objects for NMDA, 1 add ghk to NMDA
//ghk reduction factor and hoook ups to calcium shells are in Addsynapticchannels.g
// parameters for NMDA subunits
// cortex
str subunit = "ctx"
float EkNMDA = 0
float Kmg = 18 //18 new //3.57 old overwrites 1/eta in nmda_channel.g
if ({subunit}=="NR2A")
float NMDAtau2 = {(50e-3)/2}
elif ({subunit}=="NR2B")
float NMDAtau2 = (300e-3)/2
elif ({subunit}=="ctx")
float NMDAtau2 = (112.5e-3)/2 // ctx avg for .25 NR2B and .75 NR2A.
else
echo "no other NMDA subunits defined in SynParamsCtx.g"
end
float N2Aratio=1.0 //NMDA to AMPA ratio of 1:1 is in middle of measured range for striatum
float NMDAgmax = {AMPAgmax}*{N2Aratio} //0.94e-9 NR2A and B from (Moyner et al., 1994 figure 7)
//0.47e-9 using 2.75:1 NMDA:AMPA (Ding 2008), which is extreme.
float NMDAperCa = 0.2 // percent calcium influx Note: Divided by 2 in AddSynapticChannel for GHK case because of the enhanced driving potential: ohmic to GHK, reversal potentail from 0 to huge value
float NMDAfactGHK = 55e-9//35e-9 //adjustment factor for GHK to calcium shell/pool
//This is necessary because GHK reads in Gk from block and interprets it as permeability. this results in ridiculous current, restored to normal by factor of ~e-8
float NMDAdes = 0 //1 //desensitization factor, (depr_per_spike field of facsynchan)
float NMDAdestau = 0 //200e-3 // desensitixation t (how fast des recovers)
str NMDAname = {subunit}
//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines.
//parameters for NMDA calcium interactions
int NMDABufferMode = 0 // 1, connect both NMDA and AMPA calcium to Calcium_pool
// 0, connect only NMDA currents to calcium_pool
str bufferNMDA="Ca_pool_nmda"
if ({calciumtype}==0)
str NMDApool= {CalciumName}@"1"
else
str NMDApool={bufferNMDA}
end
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