Striatal Spiny Projection Neuron (SPN) plasticity rule (Jedrzejewska-Szmek et al 2016)

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Accession:189153

Reference:
1 . Jedrzejewska-Szmek J, Damodaran S, Dorman DB, Blackwell KT (2017) Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons. Eur J Neurosci 45:1044-1056 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Synaptic Plasticity;
Implementer(s): Jedrzejewska-Szmek, Joanna ; Damodaran, Sriraman ; Dorman, Daniel B ; Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Glutamate;
/
SP12
MScell
channels
BK.g *
CaL12CDI.g
CaL13CDI.g
CaNCDI.g *
CaRCDI.g
CaT.g *
CDI-GHK.g
chanplot.g *
chantest.g
GABA_tonic.g *
KaF.g *
KaFnew.g *
KaS.g
Kir.g *
Krp.g
NaF.g *
NaFslowinact.g *
nmda_channel.g
SK.g *
synaptic_channel.g
tabchanforms.g *
                            
//genesis
//nmda_channel.g

function make_NMDA_channel (chanpath, Ek, KMg, tau2, gmax, ghk, depr, deprtau)

  str chanpath //what you want the channel to be called (full path)
  float KMg, tau2, gmax  //parameters that differ between NR2A, B, C and D subunits
  float depr
  float deprtau
  float Ek
  int ghk 
  
  float tau1 =  (4.4624e-3)/2 //(5.63e-3)/8 //(4.4624e-3)/2 //  DE Chapman et al 2003, table 1 (5.63ms: wolf) w/qfact of 2 
			     //is (4.4624e-3)/2 in Evans et al., 2012
  float CMg = 1.4  // [Mg] in mM //Kerr and Plenz uses 1.4mM Mg

  float eta = 1/3.57  // Kmg = 1/eta, (per mM) overwritten by synparams, 3.57 old, 18 new
  float gamma = 99  //99 new //62 old  // per Volt

	echo "XXX make_NMDA_channel, chanpath = "{chanpath} "caBuffer = "{Ek} "KMg = "{KMg} "tau2 = "{tau2}

    make_synaptic_channel {chanpath} {tau1} {tau2} {gmax} {Ek} {depr} {deprtau}

//the kinetics of the magnesium block is different for different subunits.  
// NR2A and B are about the same, but C and D are much less affected by the block.  
//these numbers were used because the made the magnesium block curve fit the figures by Moyner et al (1994 figure 7) best by eye.

  create Mg_block {chanpath}/block
  setfield {chanpath}/block CMg {CMg} 
  setfield {chanpath}/block KMg_B {1.0/{gamma}}
  setfield {chanpath}/block KMg_A {KMg}
				
  addmsg {chanpath} {chanpath}/block CHANNEL Gk Ek

  if (ghk==1)  //GHK_yesno is set in Synparams.g
     create ghk {chanpath}/GHK
     setfield {chanpath}/GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, Wolf 5mM
     setfield {chanpath}/GHK valency 2.0
     setfield {chanpath}/GHK T {TEMPERATURE}

    //need to scale the NMDA current according to GHK kluge factor and calcium permeability
     create diffamp {chanpath}/CaCurr
     setfield {chanpath}/CaCurr gain {NMDAfactGHK} saturation 1.0

     addmsg {chanpath}/block {chanpath}/CaCurr PLUS Gk
     addmsg {chanpath}/CaCurr {chanpath}/GHK PERMEABILITY output
  end

end


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