Activity dependent regulation of pacemaker channels by cAMP (Wang et al 2002)

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Demonstration of the physiological consequences of the cyclic allosteric gating scheme for Ih mediated by HCN2 in thalamocortical relay cells.
1 . Wang J, Chen S, Nolan MF, Siegelbaum SA (2002) Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Neuron 36:451-61 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I K,leak; I h;
Gap Junctions:
Gene(s): HCN2;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics;
Implementer(s): Nolan, Matt [mfnolan at]; Chen, Shan [sc448 at];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I K,leak; I h;
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