Conditions of dominant effectiveness of distal dendrites (Korogod, Kulagina 1998)

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Accession:19366
The model illustrates and explains bistable spatial patterns of the current transfer effectiveness in the active dendrite with distributed (multiple) tonic excitatory, NMDA type, synaptic input.
Reference:
1 . Korogod SM, Kulagina IB (1998) Conditions of dominant effectiveness of distal sites of active uniform dendrites with distributed tonic inputs. Neurophysiology 30:310-315
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Active Dendrites;
Implementer(s): Korogod, Sergey M [Korogod at ff.dsu.dp.ua]; Kulagina, Irina B [Kulagina at ff.dsu.dp.ua]; Kukushka, Valery I [Valery at ff.dsu.dp.ua];
Search NeuronDB for information about:  NMDA;
// Conditions of Dominat Effectiveness of Distal Sites of Active Uniform Dendrites with Distributed Tonic Inputs
// S.M. Korogod, I.B. Kulagina
// Neirofiziologiya/Neurophysiology, Vol.30, Nos.4/5, pp.376-382, July-October, 1998

objectvar VRGraph, CRGraph, JRGraph, IRGraph

func CalcEq() {
  if (issection("Dendrite")) {
    return eq_nmda($1)
  } else {
    return erev_PasSA($1)
  }
} // CalcEq()

// make graphics for Fig.3. E
proc MakeVRGraph() {
  strdef OutLine
  VRGraph = new Graph(0)
  VRGraph.xaxis()
  VRGraph.yaxis()
  RRGraph = new RangeVarPlot("v")
  OutLine = "Axon RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  VRGraph.addobject(RRGraph, 1, 1, 1, 1)
  RRGraph = new RangeVarPlot("CalcEq($1)")
  OutLine = "Axon RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  VRGraph.addobject(RRGraph, 3, 1, 1, 3)
  VRGraph.size(-200, 800, -70, 0)
  VRGraph.view(-200, -72, 1000, 75, 268, 80, 300.0, 215.0)
  VRGraph.label(0.5, 1, "E", 2, 1, 0, 1, 1)
  VRGraph.label(0.02, 1, "mV", 2, 1, 0, 1, 1)
  VRGraph.label(0.9, 0.21, "um", 2, 1, 0, 1, 1)
  VRGraph.label(0.9, 0.95, "Eq", 2, 1, 0, 1, 3)
  VRGraph.label(0.9, 0.85, "E", 2, 1, 0, 1, 1)
  VRGraph.yaxis(3)
  VRGraph.xaxis(-200, 800, -70, 10, 0, 0, 1)
  VRGraph.yaxis(-70, 0, -200, 7, 0, 0, 1)
  flush_list.append(VRGraph)
  VRGraph.save_name("flush_list.")
  objectvar RRGraph
} // MakeVRGraph()

func CalcGnmda() { // mS/cm2
  return gnmda_nmda($1) * 1000
} // CalcGs()

func CalcGpd() { // mS/cm2
  return g_nmda($1) * 1000
} // CalcGpd()

func CalcGm() { // mS/cm2
  return (g1_nmda($1) * 1000)
} // CalcGm()

// make graphics for Fig.3. F
proc MakeCRGraph() {
  strdef OutLine
  CRGraph = new Graph(0)
  CRGraph.xaxis()
  CRGraph.yaxis()
  RRGraph = new RangeVarPlot("CalcGnmda($1)")
  OutLine = "Dendrite RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  CRGraph.addobject(RRGraph, 2, 1, 1, 2)
  RRGraph = new RangeVarPlot("CalcGpd($1)")
  OutLine = "Dendrite RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  CRGraph.addobject(RRGraph, 1, 1, 1, 1)
  RRGraph = new RangeVarPlot("CalcGm($1)")
  OutLine = "Dendrite RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  CRGraph.addobject(RRGraph, 3, 1, 1, 3)
  CRGraph.size(-200, 800, 0, 5)
  CRGraph.view(-220, -0.1, 1020, 5.1, 683, 80, 300.0, 215.0)
  CRGraph.label(0.5, 1, "F", 2, 1, 0, 1, 1)
  CRGraph.label(0.05, 1, "mS/cm2", 2, 1, 0, 1, 1)
  CRGraph.label(0.9, 0.2, "um", 2, 1, 0, 1, 1)
  CRGraph.label(0.85, 0.95, "Gm", 2, 1, 0, 1, 3)
  CRGraph.label(0.85, 0.85, "Gp,d", 2, 1, 0, 1, 1)
  CRGraph.label(0.85, 0.75, "Gnmda", 2, 1, 0, 1, 2)
  CRGraph.yaxis(3)
  CRGraph.xaxis(-200, 800, 0, 10, 0, 0, 1)
  CRGraph.yaxis(0, 5, -200, 5, 0, 0, 1)
  flush_list.append(CRGraph)
  CRGraph.save_name("flush_list.")
  objectvar RRGraph
} // MakeCRGraph()

func CalcJm() { local Jm // uA/cm2
  if (issection("Dendrite")) {
    Jm = (g1_nmda($1) * (v($1) - eq_nmda($1))) * 1000
  } else {
    Jm = (g_PasSA($1) * (v($1) - erev_PasSA($1))) * 1000
  }
  return Jm
} // CalcJm()

// make graphics for Fig.3. G
proc MakeJRGraph() {
  strdef OutLine
  JRGraph = new Graph(0)
  JRGraph.xaxis()
  JRGraph.yaxis()
  RRGraph = new RangeVarPlot("CalcJm($1)")
  OutLine = "Axon RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  JRGraph.addobject(RRGraph, 1, 1, 1, 1)
  JRGraph.size(-200, 800, -40, 40)
  JRGraph.view(-210, -45, 1010, 85, 268, 432, 300.0, 215.0)
  JRGraph.label(0.5, 1, "G", 2, 1, 0, 1, 1)
  JRGraph.label(0.05, 1, "uA/cm2", 2, 1, 0, 1, 1)
  JRGraph.label(0.9, 0.22, "um", 2, 1, 0, 1, 1)
  JRGraph.yaxis(3)
  JRGraph.xaxis(-200, 800, -40, 10, 0, 0, 1)
  JRGraph.xaxis(-200, 800, 0, 0, 0, 0, 0)
  JRGraph.yaxis(-40, 40, -200, 8, 0, 0, 1)
  flush_list.append(JRGraph)
  JRGraph.save_name("flush_list.")
  objectvar RRGraph
} // MakeJRGraph()

func CalcI() { local Jm, Im // 0.01*pA/um
  if (issection("Dendrite")) {
    Jm = (g1_nmda($1) * (v($1) - eq_nmda($1))) * 1000
  } else {
    Jm = (g_PasSA($1) * (v($1) - erev_PasSA($1))) * 1000
  }
  Im = -(PI * diam($1) * Jm)
  return Im
} // CalcI()

// make graphics for Fig.3. H
proc MakeIRGraph() {
  strdef OutLine
  IRGraph = new Graph(0)
  IRGraph.xaxis()
  IRGraph.yaxis()
  RRGraph = new RangeVarPlot("CalcI($1)")
  OutLine = "Axon RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  IRGraph.addobject(RRGraph, 1, 1, 1, 1)
  IRGraph.size(-200, 800, -500, 500)
  IRGraph.view(-220, -520, 1020, 1020, 683, 432, 300.0, 215.0)
  IRGraph.label(0.5, 1, "H", 2, 1, 0, 1, 1)
  IRGraph.label(0.05, 1, "0.01 pA/um", 2, 1, 0, 1, 1)
  IRGraph.label(0.9, 0.2, "um", 2, 1, 0, 1, 1)
  IRGraph.yaxis(3)
  IRGraph.xaxis(-200, 800, -500, 10, 0, 0, 1)
  IRGraph.xaxis(-200, 800, 0, 0, 0, 0, 0)
  IRGraph.yaxis(-500, 500, -200, 10, 0, 0, 1)
  flush_list.append(IRGraph)
  IRGraph.save_name("flush_list.")
  objectvar RRGraph
} // MakeIRGraph()

proc Destroy() {
  VRGraph.unmap()
  CRGraph.unmap()
  JRGraph.unmap()
  IRGraph.unmap()
} // Destroy()

proc MainExec() {
  GetModelTopology()
  OutLine = "access Soma"
  execute1(OutLine)
  OutLine = "Dendrite.gnmdabar_nmda = 0.0061"
  execute1(OutLine)
  tstop = 400
  MakeVRGraph()
  MakeCRGraph()
  MakeJRGraph()
  MakeIRGraph()
} // MainExec()

MainExec()

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