Conditions of dominant effectiveness of distal dendrites (Korogod, Kulagina 1998)

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Accession:19366
The model illustrates and explains bistable spatial patterns of the current transfer effectiveness in the active dendrite with distributed (multiple) tonic excitatory, NMDA type, synaptic input.
Reference:
1 . Korogod SM, Kulagina IB (1998) Conditions of dominant effectiveness of distal sites of active uniform dendrites with distributed tonic inputs. Neurophysiology 30:310-315
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Active Dendrites;
Implementer(s): Korogod, Sergey M [Korogod at ff.dsu.dp.ua]; Kulagina, Irina B [Kulagina at ff.dsu.dp.ua]; Kukushka, Valery I [Valery at ff.dsu.dp.ua];
Search NeuronDB for information about:  NMDA;
strdef ArticleLabel1, ArticleLabel2, ArticleLabel3, ArticleLabel4, ArticleLabel5
ArticleLabel1 = "Conditions of Dominat Effectiveness of Distal Sites of Active Uniform Dendrites"
ArticleLabel2 = "with Distributed Tonic Inputs"
ArticleLabel3 = "Sergey M. Korogod and Irina B. Kulagina"
ArticleLabel4 = "Neurophysiology, Vol.30, Nos.4/5, pp.376-382, July-October, 1998"
ArticleLabel5 = "Kluwer Academic/ Plenum Publishers English version: Neurophysiology 30(4/5):310-315, 1999"
objref tempobj

{
  load_file("stdgui.hoc")
  load_file("electrod.hoc")
  load_file("showmech.hoc")
  load_file("pointman.hoc")
  load_file("grapher.hoc")
}

proc MainPanel() {
   xpanel("Article Results")
   xvarlabel(ArticleLabel1)
   xvarlabel(ArticleLabel2)
   xvarlabel(ArticleLabel3)
   xvarlabel(ArticleLabel4)
   xvarlabel(ArticleLabel5)
   xlabel("")
   xbutton("Fig.1. A-C", "Main(1)")
   xbutton("Fig.2. A", "Main(2)")
   xbutton("Fig.2. B", "Main(3)")
   xbutton("Fig.3. A-D", "Main(4)")
   xbutton("Fig.3. E-H", "Main(5)")
   xlabel("")
   xpanel(410, 0)
} // MainPanel()

objectvar RRGraph

// creation of the model
proc GetModelTopology() {
  strdef OutLine
  OutLine = "create Soma"
  execute1(OutLine)
  OutLine = "access Soma"
  execute1(OutLine)
  OutLine = "Soma { nseg=2 L=20 diam=22.5 insert PasSA }"
  execute1(OutLine)
  OutLine = "create Axon"
  execute1(OutLine)
  OutLine = "Axon { nseg=20 L=200 diam=3 insert PasSA }  "
  execute1(OutLine)
  OutLine = "create Dendrite"
  execute1(OutLine)
  OutLine = "Dendrite { nseg=78 L=780 diam=5 insert nmda }"
  execute1(OutLine)
  OutLine = "connect Axon(1),Soma(0)"
  execute1(OutLine)
  OutLine = "connect Dendrite(0),Soma(1)"
  execute1(OutLine)
  define_shape()
} // GetModelTopology()

proc Destroy(){}

proc CommonDestroy() { local i
   objectvar graphList[n_graph_lists], graphItem, flush_list, fast_flush_list
   for i=0,n_graph_lists-1 graphList[i] = new List(1)
   flush_list = new List(1)
   fast_flush_list = new List(1)

   tempobj = new List("Inserter")
   while (tempobj.count()) {
      tempobj.object(0).v1.unmap()
   }
   tempobj = new List("Electrode")
   while (tempobj.count()) {
      tempobj.object(0).v1.unmap()
   }
   tempobj = new List("PointProcessManager")
   while (tempobj.count()) {
      tempobj.object(0).v1.unmap()
   }
   tempobj = new List("ShowMechanism")
   while (tempobj.count()) {
      tempobj.object(0).v1.unmap()
   }
} // CommonDestroy()

proc Main() {

  Destroy()
  CommonDestroy()

  objectvar save_window_[1], rvp_[1], scene_vector_[1], ocbox_[1]
  objectvar ocbox_list_[1], scene_list_[1], scene_[1]

  doEvents()

  forall delete_section()
  v_init = -65
  stdinit()
  if ($1 == 1) {
    xopen("Fig1_A_C.hoc")
  } else if ($1 == 2) {
    xopen("Fig2_A.hoc")
  } else if ($1 == 3) {
    xopen("Fig2_B.hoc")
  } else if ($1 == 4) {
    xopen("Fig3_A_D.hoc")
  } else if ($1 == 5) {
    xopen("Fig3_E_H.hoc")
  }
  forall Ra=100
  finitialize()
} // Main()

nrncontrolmenu()
MainPanel()

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