"In their seminal works on squid giant axons, Hodgkin, and Huxley
approximated the membrane leak current as Ohmic, i.e., linear, since
in their preparation, sub-threshold current rectification due to the
influence of ionic concentration is negligible.
Most studies on
mammalian neurons have made the same, largely untested,
assumption.
Here we show that the membrane time constant and input
resistance of mammalian neurons (when other major voltage-sensitive
and ligand-gated ionic currents are discounted) varies non-linearly
with membrane voltage, following the prediction of a
Goldman-Hodgkin-Katz-based passive membrane model.
..." (see paper for details and more).
References:
1 .
Huang S, Hong S, De Schutter E (2015) Corrigendum: Non-linear leak currents affect mammalian neuron physiology. Front Cell Neurosci 9:475 [PubMed]
2 .
Huang S, Hong S, De Schutter E (2015) Non-linear leak currents affect mammalian neuron physiology. Front Cell Neurosci 9:432 [PubMed]
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