A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)

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Accession:206238
A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites. The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
References:
1 . Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. J Neural Eng 12:046016 [PubMed]
2 . Basu I, Kudela P, Anderson WS (2014) Determination of seizure propagation across microdomains using spectral measures of causality. Conf Proc IEEE Eng Med Biol Soc 2014:6349-52 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Thalamus reticular nucleus GABA cell; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron;
Channel(s): I Na,p; I Na,t; I K; I A; I M; I h; I K,Ca; I A, slow; I L high threshold; I T low threshold; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba; Amino Acids;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Epilepsy;
Implementer(s): Anderson, WS ; Kudela, Pawel ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow; Amino Acids; Gaba; Glutamate;
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BasuEtAl2015
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ModelDescription.pdf
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P6RSd_P6RSc.g
P6RSd_P6RSd.g
P6RSd_P6RSd_Gap.g
P6RSd_raninput.g
P6RSd_ST4RS.g
P6RSd_synapsedefs.g
P6RSd_TCR.g
P6RSdcell3Dpk.p
P6RSdchanpk.g
P6RSdprotodefs.g
P6RSsyncond.g
pgenesis_command
protodefs.g
protospikeB23FS.g
protospikeB5FS.g
protospikeC23FS.g
protospikeC5FS.g
protospikeI23LTS.g
protospikeI5LTS.g
protospikenRT.g
protospikeP23FRBa.g
protospikeP23RSa.g
protospikeP23RSb.g
protospikeP23RSc.g
protospikeP23RSd.g
protospikeP5IBa.g
protospikeP5IBb.g
protospikeP5IBc.g
protospikeP5IBd.g
protospikeP5RSa.g
protospikeP6RSa.g
protospikeP6RSb.g
protospikeP6RSc.g
protospikeP6RSd.g
protospikeST4RS.g
protospikeTCR.g
randominputdefs.g
spikedefs.g
ST4RS.g
ST4RS_B23FS.g
ST4RS_B5FS.g
ST4RS_C23FS.g
ST4RS_C5FS.g
ST4RS_I23LTS.g
ST4RS_I5LTS.g
ST4RS_P23FRBa.g
ST4RS_P23RSa.g
ST4RS_P23RSb.g
ST4RS_P23RSc.g
ST4RS_P23RSd.g
ST4RS_P5IBa.g
ST4RS_P5IBb.g
ST4RS_P5IBc.g
ST4RS_P5IBd.g
ST4RS_P5RSa.g
ST4RS_P6RSa.g
ST4RS_P6RSb.g
ST4RS_P6RSc.g
ST4RS_P6RSd.g
ST4RS_raninput.g
ST4RS_ST4RS.g
ST4RS_ST4RS_Gap.g
ST4RS_synapsedefs.g
ST4RScell3Dpk.p
ST4RSchanpk.g
ST4RSprotodefs.g
ST4RSsyncond.g
synapticdelays.g *
synapticprobsTraub.g
synchansB23FS.g *
synchansB5FS.g *
synchansC23FS.g *
synchansC5FS.g *
synchansI23LTS.g *
synchansI5LTS.g *
synchansnRT.g *
synchansP23FRBa.g *
synchansP23RSa.g *
synchansP23RSb.g *
synchansP23RSc.g *
synchansP23RSd.g *
synchansP5IBa.g *
synchansP5IBb.g *
synchansP5IBc.g *
synchansP5IBd.g *
synchansP5RSa.g *
synchansP6RSa.g *
synchansP6RSb.g *
synchansP6RSc.g *
synchansP6RSd.g *
synchansSPIKEs.g *
synchansSPIKEs_base.g
synchansST4RS.g
synchansTCR.g *
syncond.g
syncond2.g
TCR.g
TCR_B23FS.g
TCR_B5FS.g
TCR_C23FS.g
TCR_C5FS.g
TCR_nRT.g
TCR_P23FRBa.g
TCR_P23RSa.g
TCR_P23RSb.g
TCR_P23RSc.g
TCR_P23RSd.g
TCR_P5IBa.g
TCR_P5IBb.g
TCR_P5IBc.g
TCR_P5IBd.g
TCR_P5RSa.g
TCR_P6RSa.g
TCR_P6RSb.g
TCR_P6RSc.g
TCR_P6RSd.g
TCR_raninput.g
TCR_ST4RS.g
TCR_synapsedefs.g
TCRcellpk.p
TCRchanpk.g
TCRprotodefs.g
TCRsyncond.g
                            
// B5FScell3Dpk.p

//	Format of file :
// x,y,z,dia are in microns, all other units are SI (Meter Kilogram Sec Amp)
// In polar mode 'r' is in microns, theta and phi in degrees 
// Control line options start with a '*'
// The format for each compartment parameter line is :
//name	parent	r	theta	phi	d	ch	dens ...
//in polar mode, and in cartesian mode :
//name	parent	x	y	z	d	ch	dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment
// For spike elements, "dens" is the spike threshold
//		Coordinate mode
*relative
*cartesian
*asymmetric

//		Specifying constants
   *set_compt_param	RM	2.50  //0.33333 (2.50)
   *set_compt_param	RA	2.00  //0.3 (2.00)
   *set_compt_param	CM	0.01  //0.01 (0.01)
   *set_compt_param     EREST_ACT	-0.07   //
   *set_compt_param     ELEAK           -0.0666   // -0.0735


//SOMA *************************************************************   
// For the soma, use the leakage potential (-0.07 + 0.0106) for Em
//*set_compt_param     ELEAK	-0.0594
// Actually, after Cunningham et al. PNAS 2004;101:7152-7157, will maintain
// leakage potential at ELEAK   -0.07
soma  none  0   0  20 15.0    Ca_s10  -5.5173713E16   NaF10  900 \
                              KDR10  1000  KA10  1  CaH10  1  KCs10  1 
// KCs10  250  KA10 10
//*set_compt_param        ELEAK   -0.075
*set_compt_param	RM	2.50  //0.33333 (2.50)
*set_compt_param	RA	2.00  //0.3 (2.00)
*set_compt_param	CM	0.01  //0.01 (0.01)

//PROXIMAL DENDRITE COMPARTMENTS ***************************************

// proxdendN   Cunningham et al., PNAS  2004;101:7152-7157
proxdendN  soma  0  0  40 2.12  Ca_d10 -3.90380092E17    NaF10     600   \
                                KDR10       1000   \
                                KA10          10   \
                                CaH10          1         KCd10     250   
                              
// proxdendE   Cunningham et al., PNAS  2004;101:7152-7157
proxdendE  soma  40  0 0 2.12    Ca_d10 -3.90380092E17   NaF10     600   \
                                 KDR10       1000   \
                                 KA10          10   \
                                 CaH10          1        KCd10     250   

// proxdendS   Cunningham et al., PNAS  2004;101:7152-7157
proxdendS  soma  0  0  -40 2.12 Ca_d10 -3.90380092E17     NaF10     600   \
                                KDR10       1000   \
                                KA10          10   \
                                CaH10          1          KCd10     250   

// proxdendW   Cunningham et al., PNAS  2004;101:7152-7157
proxdendW  soma  -40 0 0 2.12    Ca_d10 -3.90380092E17    NaF10     600   \
                                 KDR10       1000   \
                                 KA10          10   \
                                 CaH10          1         KCd10     250   

*set_compt_param	RM	2.50  //0.33333 (2.50)
*set_compt_param	RA	2.00  //0.3 (2.00)
*set_compt_param	CM	0.01  //0.01 (0.01)
//*set_compt_param     ELEAK	-0.075


//North DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendNlonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlonga  proxdendN  -6.84  11.8 37.6 1.34  Ca_d10 -6.2070579E17     NaF10     600   \
                                                  KDR10       1000   \
                                                  KA10          10   \
                                                  CaH10          1         KCd10     250   

// distdendNlongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongb  distdendNlonga  -6.84 11.8 37.6 0.84    Ca_d10 -9.8766113E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250   

// distdendNlongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongc  distdendNlongb  -6.84 11.8 37.6 0.84    Ca_d10 -9.876647E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250  

// distdendNlongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongd  distdendNlongc  -6.84 11.8 37.6 0.84    Ca_d10 -9.8765206E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250   

// distdendNlonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlonge  distdendNlongd  -6.84 11.8 37.6 0.84    Ca_d10 -9.8767418E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250   

// distdendNlongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongf  distdendNlonge  -6.84 11.8 37.6 0.84    Ca_d10 -9.876737E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250   

// distdendNlongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongg  distdendNlongf  -6.84 11.8 37.6 0.84    Ca_d10 -9.8760354E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250   

// distdendNmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendNmida  proxdendN  6.84  -11.8  37.6  1.34   Ca_d10 -6.2070579E17     NaF10     600   \
                                                    KDR10       1000   \
                                                    KA10          10   \
                                                    CaH10          1         KCd10     250   

// distdendNmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendNmidb  distdendNmida  6.84 -11.8  37.6  1.34     Ca_d10 -9.8765082E17     NaF10     100   \
                                                         KDR10       100    \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250   

// distdendNmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendNmidc  distdendNmidb  6.84 -11.8 37.6  1.34      Ca_d10 -6.2070847E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250   

// distdendNshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendNshorta  distdendNlonga   6.84  -11.8  37.6  0.84  Ca_d10 -9.8766113E17     NaF10     100   \
                                                           KDR10        100   \
                                                           KA10          10   \
                                                           CaH10          2         KCd10     250   

// distdendNshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendNshortb  distdendNshorta 6.84 -11.8 37.6  0.84   Ca_d10 -9.8768566E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250   

//East DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendElonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendElonga  proxdendE  32.5  18.8 13.68 1.34  Ca_d10 -6.2070579E17     NaF10     600   \
                                                  KDR10       1000   \
                                                  KA10          10   \
                                                  CaH10          1         KCd10     250

// distdendElongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongb  distdendElonga  32.5 18.8 13.68 0.84   Ca_d10 -9.8766113E17     NaF10     100   \
                                                       KDR10        100   \
                                                       KA10          10   \
                                                       CaH10          2         KCd10     250

// distdendElongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongc  distdendElongb  32.5 18.8 13.68 0.84  Ca_d10 -9.876647E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendElongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongd  distdendElongc  32.5 18.8 13.68 0.84   Ca_d10 -9.8765206E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendElonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendElonge  distdendElongd  32.5 18.8 13.68 0.84   Ca_d10 -9.8767418E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendElongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongf  distdendElonge  32.5 18.8 13.68 0.84   Ca_d10 -9.876737E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendElongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongg  distdendElongf  32.5 18.8 13.68 0.84   Ca_d10 -9.8760354E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendEmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendEmida  proxdendE  32.5 18.8 -13.68 1.34   Ca_d10 -6.2070579E17     NaF10     600   \
                                                    KDR10       1000   \
                                                    KA10          10   \
                                                    CaH10          1         KCd10     250

// distdendEmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendEmidb  distdendEmida 32.5 18.8 -13.68  0.84    Ca_d10 -9.8765082E17     NaF10     100   \
                                                         KDR10       100    \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

// distdendEmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendEmidc  distdendEmidb  32.5 18.8 -13.68  0.84   Ca_d10 -6.2070847E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

// distdendEshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendEshorta  distdendElonga   32.5  18.8  -13.68 0.84 Ca_d10 -9.8766113E17     NaF10     100   \
                                                           KDR10        100   \
                                                           KA10          10   \
                                                           CaH10          2         KCd10     250

// distdendEshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendEshortb  distdendEshorta 32.5 18.8 -13.68 0.84   Ca_d10 -9.8768566E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

//South DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendSlonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlonga  proxdendS  6.84  -11.8  -37.6 1.34  Ca_d10 -6.2070579E17     NaF10     600   \
                                                    KDR10       1000   \
                                                    KA10          10   \
                                                    CaH10          1         KCd10     250

// distdendSlongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongb  distdendSlonga  6.84 -11.8 -37.6 0.84    Ca_d10 -9.8766113E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendSlongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongc  distdendSlongb  6.84 -11.8 -37.6 0.84    Ca_d10 -9.876647E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendSlongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongd  distdendSlongc  6.84 -11.8 -37.6 0.84    Ca_d10 -9.8765206E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendSlonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlonge  distdendSlongd  6.84 -11.8 -37.6 0.84    Ca_d10 -9.8767418E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendSlongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongf  distdendSlonge  6.84 -11.8 -37.6 0.84    Ca_d10 -9.876737E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendSlongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongg  distdendSlongf  6.84 -11.8 -37.6 0.84    Ca_d10 -9.8760354E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendSmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendSmida  proxdendS  -6.84  11.8 -37.6 1.34   Ca_d10 -6.2070579E17     NaF10     600   \
                                                    KDR10       1000   \
                                                    KA10          10   \
                                                    CaH10          1         KCd10     250

// distdendSmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendSmidb  distdendSmida  -6.84 11.8  -37.6 0.84    Ca_d10 -9.8765082E17     NaF10     100   \
                                                         KDR10       100    \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

// distdendSmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendSmidc  distdendSmidb  -6.84 11.8 -37.6  0.84    Ca_d10 -6.2070847E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

// distdendSshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendSshorta  distdendSlonga   -6.84  11.8  -37.6 0.84  Ca_d10 -9.8766113E17     NaF10     100   \
                                                           KDR10        100   \
                                                           KA10          10   \
                                                           CaH10          2         KCd10     250

// distdendSshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendSshortb  distdendSshorta -6.84 11.8 -37.6 0.84   Ca_d10 -9.8768566E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

//West DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendWlonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlonga  proxdendW -32.5  -18.8 13.68 1.34  Ca_d10 -6.2070579E17     NaF10     600   \
                                                   KDR10       1000   \
                                                   KA10          10   \
                                                   CaH10          1         KCd10     250

// distdendWlongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongb  distdendWlonga -32.5  -18.8 13.68 0.84   Ca_d10 -9.8766113E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendWlongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongc  distdendWlongb -32.5  -18.8 13.68 0.84   Ca_d10 -9.876647E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendWlongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongd  distdendWlongc -32.5  -18.8 13.68 0.84   Ca_d10 -9.8765206E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendWlonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlonge  distdendWlongd -32.5  -18.8 13.68 0.84   Ca_d10 -9.8767418E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendWlongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongf  distdendWlonge -32.5  -18.8 13.68 0.84   Ca_d10 -9.876737E17      NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendWlongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongg  distdendWlongf -32.5  -18.8 13.68 0.84   Ca_d10 -9.8760354E17     NaF10     100   \
                                                        KDR10        100   \
                                                        KA10          10   \
                                                        CaH10          2         KCd10     250

// distdendWmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendWmida  proxdendW  -32.5 -18.8 -13.68 1.34  Ca_d10 -6.2070579E17     NaF10     600   \
                                                    KDR10       1000   \
                                                    KA10          10   \
                                                    CaH10          1         KCd10     250

// distdendWmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendWmidb  distdendWmida -32.5 -18.8 -13.68  0.84   Ca_d10 -9.8765082E17     NaF10     100   \
                                                         KDR10       100    \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

// distdendWmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendWmidc  distdendWmidb  -32.5 -18.8 -13.68  0.84  Ca_d10 -6.2070847E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

// distdendWshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendWshorta  distdendWlonga   -32.5  -18.8 -13.68 0.84 Ca_d10 -9.8766113E17     NaF10     100   \
                                                           KDR10        100   \
                                                           KA10          10   \
                                                           CaH10          2         KCd10     250

// distdendWshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendWshortb  distdendWshorta -32.5 -18.8 -13.68 0.84  Ca_d10 -9.8768566E17     NaF10     100   \
                                                         KDR10        100   \
                                                         KA10          10   \
                                                         CaH10          2         KCd10     250

//		Specifying constants for axonal compartment

   *set_compt_param	RM	0.1   // (0.1)
   *set_compt_param	RA	1.0   // (1.0)
   *set_compt_param	CM	0.01  // (0.01) RC = 0.001
   *set_compt_param     ELEAK -0.0666 
// axona Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axona  soma  0  0 -25  1.4      NaF10       4000   \
                                KDR10       4000   \
                                KA10          10   

// axonb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonb  axona  0  0 -50  1.2     NaF10       4000   \
                                KDR10       4000   \
                                KA10          10   

// axonLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLa  axonb  -8.7  0 -49.2  1.0    NaF10       4000   \
                                     KDR10       4000   \
                                     KA10          10

// axonLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLb  axonLa  -8.7  0 -49.2  1.0   NaF10       4000   \
                                     KDR10       4000   \
                                     KA10          10    

// axonRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRa  axonb   8.7  0 -49.2  1.0    NaF10       4000   \
                                     KDR10       4000   \
                                     KA10          10

// axonRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRb  axonRa   8.7  0 -49.2  1.0   NaF10       4000   \
                                     KDR10       4000   \
                                     KA10          10  

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