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A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)

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Accession:206238
A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites. The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
References:
1 . Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. J Neural Eng 12:046016 [PubMed]
2 . Basu I, Kudela P, Anderson WS (2014) Determination of seizure propagation across microdomains using spectral measures of causality. Conf Proc IEEE Eng Med Biol Soc 2014:6349-52 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Thalamus reticular nucleus GABA cell; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron;
Channel(s): I Na,p; I Na,t; I K; I A; I M; I h; I K,Ca; I A, slow; I L high threshold; I T low threshold; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba; Amino Acids;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Epilepsy;
Implementer(s): Anderson, WS ; Kudela, Pawel ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow; Amino Acids; Gaba; Glutamate;
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BasuEtAl2015
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P6RSd_P6RSa.g
P6RSd_P6RSb.g
P6RSd_P6RSc.g
P6RSd_P6RSd.g
P6RSd_P6RSd_Gap.g
P6RSd_raninput.g
P6RSd_ST4RS.g
P6RSd_synapsedefs.g
P6RSd_TCR.g
P6RSdcell3Dpk.p
P6RSdchanpk.g
P6RSdprotodefs.g
P6RSsyncond.g
pgenesis_command
protodefs.g
protospikeB23FS.g
protospikeB5FS.g
protospikeC23FS.g
protospikeC5FS.g
protospikeI23LTS.g
protospikeI5LTS.g
protospikenRT.g
protospikeP23FRBa.g
protospikeP23RSa.g
protospikeP23RSb.g
protospikeP23RSc.g
protospikeP23RSd.g
protospikeP5IBa.g
protospikeP5IBb.g
protospikeP5IBc.g
protospikeP5IBd.g
protospikeP5RSa.g
protospikeP6RSa.g
protospikeP6RSb.g
protospikeP6RSc.g
protospikeP6RSd.g
protospikeST4RS.g
protospikeTCR.g
randominputdefs.g
spikedefs.g
ST4RS.g
ST4RS_B23FS.g
ST4RS_B5FS.g
ST4RS_C23FS.g
ST4RS_C5FS.g
ST4RS_I23LTS.g
ST4RS_I5LTS.g
ST4RS_P23FRBa.g
ST4RS_P23RSa.g
ST4RS_P23RSb.g
ST4RS_P23RSc.g
ST4RS_P23RSd.g
ST4RS_P5IBa.g
ST4RS_P5IBb.g
ST4RS_P5IBc.g
ST4RS_P5IBd.g
ST4RS_P5RSa.g
ST4RS_P6RSa.g
ST4RS_P6RSb.g
ST4RS_P6RSc.g
ST4RS_P6RSd.g
ST4RS_raninput.g
ST4RS_ST4RS.g
ST4RS_ST4RS_Gap.g
ST4RS_synapsedefs.g
ST4RScell3Dpk.p
ST4RSchanpk.g
ST4RSprotodefs.g
ST4RSsyncond.g
synapticdelays.g *
synapticprobsTraub.g
synchansB23FS.g *
synchansB5FS.g *
synchansC23FS.g *
synchansC5FS.g *
synchansI23LTS.g *
synchansI5LTS.g *
synchansnRT.g *
synchansP23FRBa.g *
synchansP23RSa.g *
synchansP23RSb.g *
synchansP23RSc.g *
synchansP23RSd.g *
synchansP5IBa.g *
synchansP5IBb.g *
synchansP5IBc.g *
synchansP5IBd.g *
synchansP5RSa.g *
synchansP6RSa.g *
synchansP6RSb.g *
synchansP6RSc.g *
synchansP6RSd.g *
synchansSPIKEs.g *
synchansSPIKEs_base.g
synchansST4RS.g
synchansTCR.g *
syncond.g
syncond2.g
TCR.g
TCR_B23FS.g
TCR_B5FS.g
TCR_C23FS.g
TCR_C5FS.g
TCR_nRT.g
TCR_P23FRBa.g
TCR_P23RSa.g
TCR_P23RSb.g
TCR_P23RSc.g
TCR_P23RSd.g
TCR_P5IBa.g
TCR_P5IBb.g
TCR_P5IBc.g
TCR_P5IBd.g
TCR_P5RSa.g
TCR_P6RSa.g
TCR_P6RSb.g
TCR_P6RSc.g
TCR_P6RSd.g
TCR_raninput.g
TCR_ST4RS.g
TCR_synapsedefs.g
TCRcellpk.p
TCRchanpk.g
TCRprotodefs.g
TCRsyncond.g
                            
// cell.p - Cell parameter file used in Tutorial #5

//	Format of file :
// x,y,z,dia are in microns, all other units are SI (Meter Kilogram Sec Amp)
// In polar mode 'r' is in microns, theta and phi in degrees 
// Control line options start with a '*'
// The format for each compartment parameter line is :
//name	parent	r	theta	phi	d	ch	dens ...
//in polar mode, and in cartesian mode :
//name	parent	x	y	z	d	ch	dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment
// For spike elements, "dens" is the spike threshold
//		Coordinate mode
*relative
*cartesian
*asymmetric

//		Specifying constants
*set_compt_param	RM	5.0   //5.0
*set_compt_param	RA	2.50  //2.50
*set_compt_param	CM	0.009 //0.009
*set_compt_param     EREST_ACT	-0.07
*set_compt_param      ELEAK     -0.0666


//SOMA *************************************************************   
// For the soma, use the leakage potential (-0.07 + 0.0106) for Em
// Actually, after Traub et al. J Neurophys 2003;89:909-921, will maintain
// leakage potential at ELEAK   -0.07
soma  none   0  0  15  16     Ca_s1 -6.8967141E15     NaF1       1875   \
                              NaP1          1.2       KDR1       1250   \
                              KA1         300         K21           1   \
                              KM1          75         CaL1          1   \
                              CaH1         10         KCs1        120   \
                              AR1         2.5         KAHPs1        0.4 
*set_compt_param     RA 2.5
*set_compt_param     CM 0.018
*set_compt_param     ELEAK -0.0666
*set_compt_param     RM 2.5


//APICAL DENDRITE COMPARTMENTS ***************************************
// apdend1 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend1  soma  0  0  50  8      Ca_d1 -8.2760568E15     NaF1       2500   \
                                NaP1        1.6         KDR1       2500   \
                                KA1         600         K21           2   \
                                KM1         150         CaL1          2   \
                                CaH1         20         KCd1        240   \
                                AR1           5         KAHPd1      0.8 

// apdend2 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend2  apdend1  0  0  50  7.2    Ca_d1 -9.1956195E15      NaF1        1875 \
                                    NaP1        1.2         KDR1        1875 \
                                    KA1          40         K21           2  \
                                    KM1         150         CaL1          2  \
                                    CaH1         20         KCd1        240  \
                                    AR1           5         KAHPd1      0.8


// apdend3 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend3  apdend2  0  0  50  6.4    Ca_d1 -1.03450719E16    NaF1        250  \
                                    NaP1          0.16      KDR1       125  \
                                    KA1          40         K21          2  \
                                    KM1         150         CaL1         2  \
                                    CaH1         20         KCd1       240  \
                                    AR1           5         KAHPd1     0.8  

// apdend4aR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend4aR  apdend3 25 0 43.3 4.00   Ca_d1 -1.65522596E16    NaF1       250  \
                                    NaP1       0.16         KDR1       125  \
                                    KA1          40         K21          2  \
                                    KM1         150         CaL1         2  \
                                    CaH1         20         KCd1       240  \
                                    AR1           5         KAHPd1     0.8

// apdend4bR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend4bR  apdend4aR 25 0 43.3 4.00 Ca_d1 -1.65522886E16    NaF1         250  \
                                    NaP1       0.16         KDR1         125  \
                                    KA1          40         K21            2  \
                                    KM1         150         CaL1           2  \
                                    CaH1         20         KCd1         240  \
                                    AR1           5         KAHPd1       0.8

// apdend5aRRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aRRR  apdend4bR 6.4 11.2 48.3 1.6 Ca_d1 -4.1380253E16     NaF1         250    \
                                       NaP1          0.16      KDR1          125   \
                                       KA1          40         K21            2    \
                                       KM1         150         CaL1           2    \
                                       CaH1         20         KCd1         240    \
                                       AR1           5         KAHPd1         0.8

// apdend5bRRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bRRR  apdend5aRRR 6.4 11.2 48.3 1.6 Ca_d1 -4.1380215E16   NaF1         250    \
                                       NaP1        0.16        KDR1          125   \
                                       KA1          40         K21            2    \
                                       KM1         150         CaL1           2    \
                                       CaH1         20         KCd1         240    \
                                       AR1           5         KAHPd1         0.8

// apdend5cRRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cRRR  apdend5bRRR 6.4 11.2 48.3  1.6 Ca_d1 -4.1379334E16     NaF1         250    \
                                         NaP1          0.16      KDR1          125   \
                                         KA1          40         K21            2    \
                                         KM1         150         CaL1           2    \
                                         CaH1         20         KCd1         240    \
                                         AR1           5         KAHPd1         0.8

// apdend5aRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aRR  apdend4bR 2.2 -3.8 49.8 1.6   Ca_d1 -4.1380253E16     NaF1         250    \
                                       NaP1          0.16      KDR1          125   \
                                       KA1          40         K21            2    \
                                       KM1         150         CaL1           2    \
                                       CaH1         20         KCd1         240    \
                                       AR1           5         KAHPd1         0.8

// apdend5bRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bRR  apdend5aRR 2.2 -3.8 49.8 1.6   Ca_d1 -4.1380215E16   NaF1         250    \
                                       NaP1        0.16        KDR1          125   \
                                       KA1          40         K21            2    \
                                       KM1         150         CaL1           2    \
                                       CaH1         20         KCd1         240    \
                                       AR1           5         KAHPd1         0.8

// apdend5cRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cRR  apdend5bRR 2.2 -3.8 49.8  1.6   Ca_d1 -4.1379334E16     NaF1         250    \
                                         NaP1          0.16      KDR1          125   \
                                         KA1          40         K21            2    \
                                         KM1         150         CaL1           2    \
                                         CaH1         20         KCd1         240    \
                                         AR1           5         KAHPd1         0.8

// apdend5aRLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aRLL  apdend4bR -11.2 -6.4 48.3 1.6 Ca_d1 -4.1380253E16     NaF1         250    \
                                          NaP1          0.16      KDR1          125   \
                                          KA1          40         K21            2    \
                                          KM1         150         CaL1           2    \
                                          CaH1         20         KCd1         240    \
                                          AR1           5         KAHPd1         0.8

// apdend5bRLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bRLL  apdend5aRLL -11.2 -6.4 48.3 1.6 Ca_d1 -4.1380215E16   NaF1         250    \
                                             NaP1        0.16        KDR1          125   \
                                             KA1          40         K21            2    \
                                             KM1         150         CaL1           2    \
                                             CaH1         20         KCd1         240    \
                                             AR1           5         KAHPd1         0.8

// apdend5cRLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cRLL  apdend5bRLL -11.2 -6.4 48.3 1.6 Ca_d1 -4.1379334E16     NaF1         250    \
                                             NaP1          0.16      KDR1          125   \
                                             KA1          40         K21            2    \
                                             KM1         150         CaL1           2    \
                                             CaH1         20         KCd1         240    \
                                              AR1           5         KAHPd1         0.8

// apdend5aRL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aRL  apdend4bR -3.8 2.2 49.8 1.6  Ca_d1 -4.1380253E16     NaF1         250    \
                                       NaP1          0.16      KDR1          125   \
                                       KA1          40         K21            2    \
                                       KM1         150         CaL1           2    \
                                       CaH1         20         KCd1         240    \
                                       AR1           5         KAHPd1         0.8

// apdend5bRL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bRL  apdend5aRL -3.8 2.2 49.8 1.6  Ca_d1 -4.1380215E16   NaF1         250    \
                                       NaP1        0.16        KDR1          125   \
                                       KA1          40         K21            2    \
                                       KM1         150         CaL1           2    \
                                       CaH1         20         KCd1         240    \
                                       AR1           5         KAHPd1         0.8

// apdend5cRL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cRL  apdend5bRL -3.8 2.2 49.8 1.6  Ca_d1 -4.1379334E16     NaF1         250    \
                                         NaP1          0.16      KDR1          125   \
                                         KA1          40         K21            2    \
                                         KM1         150         CaL1           2    \
                                         CaH1         20         KCd1         240    \
                                         AR1           5         KAHPd1         0.8

// apdend4aL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend4aL  apdend3 -25 0 43.3 4.00     Ca_d1 -1.65523176E16    NaF1        250 \
                                       NaP1          0.16      KDR1        125 \
                                       KA1          40         K21          2  \
                                       KM1         150         CaL1         2  \
                                       CaH1         20         KCd1       240  \
                                       AR1           5         KAHPd1     0.8

// apdend4bL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend4bL  apdend4aL -25 0 43.3 4.00   Ca_d1 -1.65522886E16    NaF1         250  \
                                       NaP1       0.16         KDR1         125  \
                                       KA1          40         K21            2  \
                                       KM1         150         CaL1           2  \
                                       CaH1         20         KCd1         240  \
                                       AR1           5         KAHPd1       0.8

// apdend5aLLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aLLL  apdend4bL -6.4 11.2 48.3 1.6 Ca_d1 -4.1380253E16     NaF1         250    \
                                          NaP1          0.16      KDR1          125   \
                                          KA1          40         K21            2    \
                                          KM1         150         CaL1           2    \
                                          CaH1         20         KCd1         240    \
                                          AR1           5         KAHPd1         0.8

// apdend5bLLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bLLL  apdend5aLLL -6.4 11.2 48.3 1.6 Ca_d1 -4.1380215E16   NaF1         250    \
                                            NaP1        0.16        KDR1          125   \
                                            KA1          40         K21            2    \
                                            KM1         150         CaL1           2    \
                                            CaH1         20         KCd1         240    \
                                            AR1           5         KAHPd1         0.8

// apdend5cLLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cLLL  apdend5bLLL -6.4 11.2 48.3 1.6 Ca_d1 -4.1379334E16     NaF1         250    \
                                            NaP1          0.16      KDR1          125   \
                                            KA1          40         K21            2    \
                                            KM1         150         CaL1           2    \
                                            CaH1         20         KCd1         240    \
                                            AR1           5         KAHPd1         0.8

// apdend5aLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aLL  apdend4bL -2.2 -3.8 49.8 1.6  Ca_d1 -4.1380253E16     NaF1         250    \
                                          NaP1          0.16      KDR1          125   \
                                          KA1          40         K21            2    \
                                          KM1         150         CaL1           2    \
                                          CaH1         20         KCd1         240    \
                                          AR1           5         KAHPd1         0.8

// apdend5bLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bLL  apdend5aLL -2.2 -3.8 49.8 1.6 Ca_d1 -4.1380215E16   NaF1         250    \
                                          NaP1        0.16        KDR1          125   \
                                          KA1          40         K21            2    \
                                          KM1         150         CaL1           2    \
                                          CaH1         20         KCd1         240    \
                                          AR1           5         KAHPd1         0.8

// apdend5cLL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cLL  apdend5bLL -2.2 -3.8 49.8 1.6 Ca_d1 -4.1379334E16     NaF1         250    \
                                          NaP1          0.16      KDR1          125   \
                                          KA1          40         K21            2    \
                                          KM1         150         CaL1           2    \
                                          CaH1         20         KCd1         240    \
                                          AR1           5         KAHPd1         0.8

// apdend5aLRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aLRR  apdend4bL 11.2 -6.4 48.3 1.6 Ca_d1 -4.1380253E16     NaF1         250    \
                                          NaP1          0.16      KDR1          125   \
                                          KA1          40         K21            2    \
                                          KM1         150         CaL1           2    \
                                          CaH1         20         KCd1         240    \
                                          AR1           5         KAHPd1         0.8

// apdend5bLRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bLRR  apdend5aLRR 11.2 -6.4 48.3 1.6 Ca_d1 -4.1380215E16   NaF1         250    \
                                            NaP1        0.16        KDR1          125   \
                                            KA1          40         K21            2    \
                                            KM1         150         CaL1           2    \
                                            CaH1         20         KCd1         240    \
                                            AR1           5         KAHPd1         0.8

// apdend5cLRR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cLRR  apdend5bLRR 11.2 -6.4 48.3 1.6 Ca_d1 -4.1379334E16     NaF1         250    \
                                            NaP1          0.16      KDR1          125   \
                                            KA1          40         K21            2    \
                                            KM1         150         CaL1           2    \
                                            CaH1         20         KCd1         240    \
                                            AR1           5         KAHPd1         0.8

// apdend5aLR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5aLR  apdend4bL 3.8 2.2 49.8 1.6  Ca_d1 -4.1380253E16     NaF1         250    \
                                        NaP1          0.16      KDR1          125   \
                                        KA1          40         K21            2    \
                                        KM1         150         CaL1           2    \
                                        CaH1         20         KCd1         240    \
                                        AR1           5         KAHPd1         0.8

// apdend5bLR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5bLR  apdend5aLR 3.8 2.2 49.8 1.6 Ca_d1 -4.1380215E16   NaF1         250    \
                                        NaP1        0.16        KDR1          125   \
                                        KA1          40         K21            2    \
                                        KM1         150         CaL1           2    \
                                        CaH1         20         KCd1         240    \
                                        AR1           5         KAHPd1         0.8

// apdend5cLR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5cLR  apdend5bLR 3.8 2.2 49.8 1.6  Ca_d1 -4.1379334E16     NaF1         250    \
                                         NaP1          0.16      KDR1          125   \
                                         KA1          40         K21            2    \
                                         KM1         150         CaL1           2    \
                                         CaH1         20         KCd1         240    \
                                         AR1           5         KAHPd1         0.8

//APICAL OBLIQUE DENDRITE COMPARTMENTS ***************************************
// apobdistRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRa  apdend1  35.4  35.4  0  1.0  Ca_d1 -6.6208454E16     NaF1        1875   \
                                         NaP1         1.2        KDR1        1875   \
                                         KA1          40         K21           2    \
                                         KM1         150         CaL1          2    \
                                         CaH1         20         KCd1        240    \
                                         AR1          5         KAHPd1        0.8

// apobdistRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRb  apobdistRa 35.4  35.4  0  1.0 Ca_d1 -6.6208454E16     NaF1      250   \
                                          NaP1          0.16      KDR1      125   \
                                          KA1          40         K21       2     \
                                          KM1          150        CaL1      2     \
                                          CaH1         20         KCd1     240    \
                                          AR1          5         KAHPd1    0.8

// apobdistRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRc  apobdistRb  35.4  35.4  0 1.0  Ca_d1 -6.6208454E16  NaF1       250  \
                                           NaP1        0.16     KDR1       125  \
                                           KA1          40      K21         2   \
                                           KM1         150      CaL1        2   \
                                           CaH1         20      KCd1       240  \
                                           AR1          5       KAHPd1     0.8

// apobproxRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRa  apdend1  35.4  -35.4  0  1.0  Ca_d1 -6.6208454E16     NaF1     1875   \
                                          NaP1         1.2        KDR1     1875   \
                                          KA1          40         K21        2    \
                                          KM1         150         CaL1       2    \
                                          CaH1         20         KCd1     240    \
                                          AR1          5         KAHPd1     0.8

// apobproxRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRb apobproxRa 35.4 -35.4 0 1.0  Ca_d1  -6.6208454E16   NaF1   250   \
                                        NaP1        0.16       KDR1   125   \
                                        KA1          40        K21      2   \
                                        KM1         150        CaL1     2   \
                                        CaH1         20        KCd1   240   \
                                        AR1          5         KAHPd1 0.8
 
// apobproxRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRc  apobproxRb  35.4  -35.4  0  1.0   Ca_d1 -6.6208454E16  NaF1     250  \
                                              NaP1        0.16     KDR1     125  \
                                              KA1          40      K21       2   \
                                              KM1         150      CaL1      2   \
                                              CaH1         20      KCd1     240  \
                                              AR1          5       KAHPd1   0.8

// apobdistLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLa  apdend1  -35.4  35.4  0  1.0  Ca_d1 -6.6208454E16     NaF1     1875   \
                                          NaP1         1.2        KDR1     1875   \
                                          KA1          40         K21        2    \
                                          KM1         150         CaL1       2    \
                                          CaH1         20         KCd1     240    \
                                          AR1          5         KAHPd1     0.8

// apobdistLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLb  apobdistLa  -35.4  35.4  0  1.0  Ca_d1 -6.6208454E16     NaF1      250    \
                                             NaP1          0.16      KDR1      125   \
                                             KA1          40         K21        2    \
                                             KM1          150        CaL1       2    \
                                             CaH1         20         KCd1      240    \
                                             AR1          5         KAHPd1     0.8

// apobdistLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLc  apobdistLb  -35.4  35.4  0  1.0  Ca_d1 -6.6208454E16  NaF1       250    \
                                             NaP1        0.16    KDR1        125  \
                                             KA1          40     K21          2    \
                                             KM1         150     CaL1         2    \
                                             CaH1         20     KCd1        240    \
                                             AR1          5      KAHPd1      0.8

// apobproxLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLa  apdend1  -35.4  -35.4  0  1.0  Ca_d1 -6.6208454E16     NaF1        1875   \
                                           NaP1         1.2        KDR1        1875   \
                                           KA1          40         K21           2    \
                                           KM1         150         CaL1          2    \
                                           CaH1         20         KCd1        240    \
                                           AR1          5         KAHPd1        0.8

// apobproxLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLb  apobproxLa  -35.4  -35.4  0  1.0   Ca_d1 -6.6208454E16     NaF1     250    \
                                               NaP1          0.16      KDR1     125   \
                                               KA1          40         K21       2    \
                                               KM1          150        CaL1      2    \
                                               CaH1         20         KCd1     240    \
                                               AR1          5         KAHPd1    0.8

// apobproxLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLc  apobproxLb  -35.4  -35.4  0  1.0  Ca_d1 -6.6208454E16  NaF1    250    \
                                              NaP1        0.16    KDR1     125  \
                                              KA1          40     K21        2    \
                                              KM1         150     CaL1       2    \
                                              CaH1         20     KCd1     240    \
                                              AR1          5      KAHPd1   0.8

//BASAL DENDRITE COMPARTMENTS ************************************************
// basalLdeepa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLdeepa  soma  -9.4  -16.2  -46.4  1.0  Ca_d1  -6.620845E16     NaF1    1875  \
                                            NaP1         1.2        KDR1    1875  \
                                            KA1          40         K21       2    \
                                            KM1         150         CaL1      2    \
                                            CaH1         20         KCd1    240    \
                                            AR1          5          KAHPd1    0.8

// basalLdeepb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLdeepb  basalLdeepa -9.4  -16.2 -46.4  1.0  Ca_d1 -6.6208467E16     NaF1       250   \
                                                 NaP1        0.16        KDR1       125  \
                                                 KA1          40         K21         2    \
                                                 KM1         150         CaL1        2    \
                                                 CaH1         20         KCd1      240    \
                                                 AR1          5          KAHPd1      0.8

// basalLdeepc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLdeepc  basalLdeepb -9.4  -16.2 -46.4 1.0  Ca_d1 -6.6207608E16     NaF1      250   \
                                                NaP1         0.16       KDR1       125  \
                                                KA1          40         K21         2   \
                                                KM1          150        CaL1        2   \
                                                CaH1         20         KCd1      240   \
                                                AR1          5         KAHPd1      0.8

// basalLmiddeepa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmiddeepa  soma  -18.3  31.7  -34.1  1.0  Ca_d1  -6.620845E16     NaF1    1875  \
                                               NaP1         1.2        KDR1    1875  \
                                               KA1          40         K21       2    \
                                               KM1         150         CaL1      2    \
                                               CaH1         20         KCd1    240    \
                                               AR1          5          KAHPd1    0.8

// basalLmiddeepb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmiddeepb  basalLmiddeepa -18.3  31.7 -34.1  1.0 Ca_d1 -6.6208467E16     NaF1       250   \
                                                      NaP1        0.16        KDR1       125  \
                                                      KA1          40         K21         2    \
                                                      KM1         150         CaL1        2    \
                                                      CaH1         20         KCd1      240    \
                                                      AR1          5          KAHPd1      0.8

// basalLmiddeepc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmiddeepc  basalLmiddeepb -18.3  31.7 -34.1 1.0 Ca_d1 -6.6207608E16     NaF1      250   \
                                                     NaP1         0.16       KDR1       125  \
                                                     KA1          40         K21         2   \
                                                     KM1          150        CaL1        2   \
                                                     CaH1         20         KCd1      240   \
                                                     AR1          5         KAHPd1      0.8

// basalLmidsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmidsupera  soma  -40.2  -23.2  -18.7  1.0  Ca_d1  -6.620845E16     NaF1    1875  \
                                                 NaP1         1.2        KDR1    1875  \
                                                 KA1          40         K21       2    \
                                                 KM1         150         CaL1      2    \
                                                 CaH1         20         KCd1    240    \
                                                 AR1          5          KAHPd1    0.8

// basalLmidsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmidsuperb  basalLmidsupera -40.2  -23.2 -18.7  1.0  Ca_d1 -6.6208467E16     NaF1       250   \
                                                          NaP1        0.16        KDR1       125  \
                                                          KA1          40         K21         2    \
                                                          KM1         150         CaL1        2    \
                                                          CaH1         20         KCd1      240    \
                                                          AR1          5          KAHPd1      0.8

// basalLmidsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmidsuperc  basalLmidsuperb -40.2  -23.2 -18.7 1.0  Ca_d1 -6.6207608E16     NaF1      250   \
                                                         NaP1         0.16       KDR1       125  \
                                                         KA1          40         K21         2   \
                                                         KM1          150        CaL1        2   \
                                                         CaH1         20         KCd1      240   \
                                                         AR1          5         KAHPd1      0.8

// basalLsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsupera  soma  -42.6  24.6  -8.7 1.0   Ca_d1  -6.620845E16     NaF1    1875  \
                                            NaP1         1.2        KDR1    1875  \
                                            KA1          40         K21       2    \
                                            KM1         150         CaL1      2    \
                                            CaH1         20         KCd1    240    \
                                            AR1          5          KAHPd1    0.8

// basalLsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsuperb  basalLsupera -42.6  24.6 -8.7  1.0  Ca_d1 -6.6208467E16     NaF1       250   \
                                                  NaP1        0.16        KDR1       125  \
                                                  KA1          40         K21         2    \
                                                  KM1         150         CaL1        2    \
                                                  CaH1         20         KCd1      240    \
                                                  AR1          5          KAHPd1      0.8

// basalLsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsuperc  basalLsuperb -42.6  24.6 -8.7 1.0   Ca_d1 -6.6207608E16     NaF1      250   \
                                                  NaP1         0.16       KDR1       125  \
                                                  KA1          40         K21         2   \
                                                  KM1          150        CaL1        2   \
                                                  CaH1         20         KCd1      240   \
                                                  AR1          5         KAHPd1      0.8

// basalRdeepa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRdeepa  soma   9.4  -16.2   -46.4  1.0  Ca_d1  -6.620845E16     NaF1    1875  \
                                             NaP1         1.2        KDR1    1875  \
                                             KA1          40         K21       2    \
                                             KM1         150         CaL1      2    \
                                             CaH1         20         KCd1    240    \
                                             AR1          5          KAHPd1    0.8

// basalRdeepb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRdeepb  basalRdeepa  9.4  -16.2  -46.4  1.0  Ca_d1 -6.6208467E16     NaF1       250   \
                                                  NaP1        0.16        KDR1       125  \
                                                  KA1          40         K21         2    \
                                                  KM1         150         CaL1        2    \
                                                  CaH1         20         KCd1      240    \
                                                  AR1          5          KAHPd1      0.8

// basalRdeepc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRdeepc  basalRdeepb  9.4  -16.2  -46.4 1.0  Ca_d1 -6.6207608E16     NaF1      250   \
                                                 NaP1         0.16       KDR1       125  \
                                                 KA1          40         K21         2   \
                                                 KM1          150        CaL1        2   \
                                                 CaH1         20         KCd1      240   \
                                                 AR1          5         KAHPd1      0.8

// basalRmiddeepa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmiddeepa  soma   18.3  31.7  -34.1  1.0  Ca_d1  -6.620845E16     NaF1    1875  \
                                               NaP1         1.2        KDR1    1875  \
                                               KA1          40         K21       2    \
                                               KM1         150         CaL1      2    \
                                               CaH1         20         KCd1    240    \
                                               AR1          5          KAHPd1    0.8

// basalRmiddeepb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmiddeepb  basalRmiddeepa  18.3  31.7 -34.1  1.0  Ca_d1 -6.6208467E16     NaF1       250   \
                                                       NaP1        0.16        KDR1       125  \
                                                       KA1          40         K21         2    \
                                                       KM1         150         CaL1        2    \
                                                       CaH1         20         KCd1      240    \
                                                       AR1          5          KAHPd1      0.8

// basalRmiddeepc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmiddeepc  basalRmiddeepb  18.3  31.7 -34.1 1.0  Ca_d1 -6.6207608E16     NaF1      250   \
                                                      NaP1         0.16       KDR1       125  \
                                                      KA1          40         K21         2   \
                                                      KM1          150        CaL1        2   \
                                                      CaH1         20         KCd1      240   \
                                                      AR1          5         KAHPd1      0.8

// basalRmidsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmidsupera  soma  40.2  -23.2  -18.7  1.0  Ca_d1  -6.620845E16     NaF1    1875  \
                                              NaP1         1.2        KDR1    1875  \
                                              KA1          40         K21       2    \
                                              KM1         150         CaL1      2    \
                                              CaH1         20         KCd1    240    \
                                              AR1          5          KAHPd1    0.8

// basalRmidsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmidsuperb  basalRmidsupera  40.2  -23.2 -18.7  1.0  Ca_d1 -6.6208467E16     NaF1       250   \
                                                          NaP1        0.16        KDR1       125  \
                                                          KA1          40         K21         2    \
                                                          KM1         150         CaL1        2    \
                                                          CaH1         20         KCd1      240    \
                                                          AR1          5          KAHPd1      0.8

// basalRmidsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmidsuperc  basalRmidsuperb  40.2  -23.2 -18.7 1.0  Ca_d1 -6.6207608E16     NaF1      250   \
                                                         NaP1         0.16       KDR1       125  \
                                                         KA1          40         K21         2   \
                                                         KM1          150        CaL1        2   \
                                                         CaH1         20         KCd1      240   \
                                                         AR1          5         KAHPd1      0.8

// basalRsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsupera  soma  42.6  24.6 -8.7 1.0   Ca_d1  -6.620845E16     NaF1    1875  \
                                          NaP1         1.2        KDR1    1875  \
                                          KA1          40         K21       2    \
                                          KM1         150         CaL1      2    \
                                          CaH1         20         KCd1    240    \
                                          AR1          5          KAHPd1    0.8

// basalRsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsuperb  basalRsupera  42.6  24.6 -8.7  1.0  Ca_d1 -6.6208467E16     NaF1       250   \
                                                  NaP1        0.16        KDR1       125  \
                                                  KA1          40         K21         2    \
                                                  KM1         150         CaL1        2    \
                                                  CaH1         20         KCd1      240    \
                                                  AR1          5          KAHPd1      0.8

// basalRsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsuperc  basalRsuperb  42.6  24.6 -8.7 1.0  Ca_d1 -6.6207608E16     NaF1      250   \
                                                 NaP1         0.16       KDR1       125  \
                                                 KA1          40         K21         2   \
                                                 KM1          150        CaL1        2   \
                                                 CaH1         20         KCd1      240   \
                                                 AR1          5         KAHPd1      0.8

//		Specifying constants for axonal compartment RMCM=0.0024 (0.0009)
*set_compt_param	RM	0.10   //(0.1)
*set_compt_param	RA	1.00   //(1.00)
*set_compt_param	CM	0.009  //(0.009)(0.024)
//*set_compt_param     EREST_ACT	-0.07
//*set_compt_param     ELEAK	        -0.07

//AXONAL COMPARTMENTS ***************************************
// axona Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axona  soma  0  0 -25  1.8      NaF1       4000   \
                                NaP1          0.0       KDR1       4000   \
                                KA1          20         K21           1   \
                                KM1           0         CaL1          0   \
                                CaH1          0   \
                                AR1           0  

// axonb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonb  axona  0  0 -50  1.4     NaF1       4000   \
                                NaP1          0.0       KDR1       4000   \
                                KA1          20         K21           1   \
                                KM1           0         CaL1          0   \
                                CaH1          0   \
                                AR1           0  


// axonLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLa  axonb  -8.7  0 -49.2  1.0     NaF1       4000   \
                                      NaP1          0.0       KDR1       4000   \
                                      KA1          20         K21           1   \
                                      KM1           0         CaL1          0   \
                                      CaH1          0   \
                                      AR1           0  

// axonLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLb  axonLa  -8.7  0 -49.2  1.0     NaF1       4000   \
                                       NaP1          0.0       KDR1       4000   \
                                       KA1          20         K21           1   \
                                       KM1           0         CaL1          0   \
                                       CaH1          0   \
                                       AR1           0 

// axonRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRa  axonb   8.7  0 -49.2  1.0    NaF1       4000   \
                                     NaP1          0.0       KDR1       4000   \
                                     KA1          20         K21           1   \
                                     KM1           0         CaL1          0   \
                                     CaH1          0   \
                                     AR1           0 

// axonRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRb  axonRa   8.7  0 -49.2  1.0   NaF1       4000   \
                                     NaP1          0.0       KDR1       4000   \
                                     KA1          20         K21           1   \
                                     KM1           0         CaL1          0   \
                                     CaH1          0   \
                                     AR1           0    

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