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A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)

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Accession:206238
A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites. The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
References:
1 . Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. J Neural Eng 12:046016 [PubMed]
2 . Basu I, Kudela P, Anderson WS (2014) Determination of seizure propagation across microdomains using spectral measures of causality. Conf Proc IEEE Eng Med Biol Soc 2014:6349-52 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Thalamus reticular nucleus GABA cell; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron;
Channel(s): I Na,p; I Na,t; I K; I A; I M; I h; I K,Ca; I A, slow; I L high threshold; I T low threshold; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba; Amino Acids;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Epilepsy;
Implementer(s): Anderson, WS ; Kudela, Pawel ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow; Amino Acids; Gaba; Glutamate;
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BasuEtAl2015
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P6RSd_P6RSa.g
P6RSd_P6RSb.g
P6RSd_P6RSc.g
P6RSd_P6RSd.g
P6RSd_P6RSd_Gap.g
P6RSd_raninput.g
P6RSd_ST4RS.g
P6RSd_synapsedefs.g
P6RSd_TCR.g
P6RSdcell3Dpk.p
P6RSdchanpk.g
P6RSdprotodefs.g
P6RSsyncond.g
pgenesis_command
protodefs.g
protospikeB23FS.g
protospikeB5FS.g
protospikeC23FS.g
protospikeC5FS.g
protospikeI23LTS.g
protospikeI5LTS.g
protospikenRT.g
protospikeP23FRBa.g
protospikeP23RSa.g
protospikeP23RSb.g
protospikeP23RSc.g
protospikeP23RSd.g
protospikeP5IBa.g
protospikeP5IBb.g
protospikeP5IBc.g
protospikeP5IBd.g
protospikeP5RSa.g
protospikeP6RSa.g
protospikeP6RSb.g
protospikeP6RSc.g
protospikeP6RSd.g
protospikeST4RS.g
protospikeTCR.g
randominputdefs.g
spikedefs.g
ST4RS.g
ST4RS_B23FS.g
ST4RS_B5FS.g
ST4RS_C23FS.g
ST4RS_C5FS.g
ST4RS_I23LTS.g
ST4RS_I5LTS.g
ST4RS_P23FRBa.g
ST4RS_P23RSa.g
ST4RS_P23RSb.g
ST4RS_P23RSc.g
ST4RS_P23RSd.g
ST4RS_P5IBa.g
ST4RS_P5IBb.g
ST4RS_P5IBc.g
ST4RS_P5IBd.g
ST4RS_P5RSa.g
ST4RS_P6RSa.g
ST4RS_P6RSb.g
ST4RS_P6RSc.g
ST4RS_P6RSd.g
ST4RS_raninput.g
ST4RS_ST4RS.g
ST4RS_ST4RS_Gap.g
ST4RS_synapsedefs.g
ST4RScell3Dpk.p
ST4RSchanpk.g
ST4RSprotodefs.g
ST4RSsyncond.g
synapticdelays.g *
synapticprobsTraub.g
synchansB23FS.g *
synchansB5FS.g *
synchansC23FS.g *
synchansC5FS.g *
synchansI23LTS.g *
synchansI5LTS.g *
synchansnRT.g *
synchansP23FRBa.g *
synchansP23RSa.g *
synchansP23RSb.g *
synchansP23RSc.g *
synchansP23RSd.g *
synchansP5IBa.g *
synchansP5IBb.g *
synchansP5IBc.g *
synchansP5IBd.g *
synchansP5RSa.g *
synchansP6RSa.g *
synchansP6RSb.g *
synchansP6RSc.g *
synchansP6RSd.g *
synchansSPIKEs.g *
synchansSPIKEs_base.g
synchansST4RS.g
synchansTCR.g *
syncond.g
syncond2.g
TCR.g
TCR_B23FS.g
TCR_B5FS.g
TCR_C23FS.g
TCR_C5FS.g
TCR_nRT.g
TCR_P23FRBa.g
TCR_P23RSa.g
TCR_P23RSb.g
TCR_P23RSc.g
TCR_P23RSd.g
TCR_P5IBa.g
TCR_P5IBb.g
TCR_P5IBc.g
TCR_P5IBd.g
TCR_P5RSa.g
TCR_P6RSa.g
TCR_P6RSb.g
TCR_P6RSc.g
TCR_P6RSd.g
TCR_raninput.g
TCR_ST4RS.g
TCR_synapsedefs.g
TCRcellpk.p
TCRchanpk.g
TCRprotodefs.g
TCRsyncond.g
                            
// P5IBa.p - for TraubIB_VP

//	Format of file :
// x,y,z,dia are in microns, all other units are SI (Meter Kilogram Sec Amp)
// In polar mode 'r' is in microns, theta and phi in degrees 
// Control line options start with a '*'
// The format for each compartment parameter line is :
//name	parent	r	theta	phi	d	ch	dens ...
//in polar mode, and in cartesian mode :
//name	parent	x	y	z	d	ch	dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment
// For spike elements, "dens" is the spike threshold
//		Coordinate mode
*relative
*cartesian
*asymmetric

//		Specifying constants
   *set_compt_param	RM	5.0   // 5.0
   *set_compt_param	RA	2.50  // 2.50
   *set_compt_param	CM	0.009 // 0.009
   *set_compt_param     EREST_ACT	-0.07 // -0.075
   *set_compt_param     ELEAK           -0.0666 // -0.075


//SOMA *************************************************************   
// For the soma, use the leakage potential (-0.07 + 0.0106) for Em
//*set_compt_param     ELEAK	-0.0594
// Actually, after Traub et al. J Neurophys 2003;89:909-921, will maintain
// leakage potential at ELEAK   -0.07
soma  none   0  0  15  18     Ca_s6 -6.1304081E14 NaF6           2000     \
                              NaP6        1.6     KDR6           1700     \
                              KA6         200     K26               5     \
                              KM6         119     CaL6              1     \
                              CaH6         40     KCs6            160     \
                              AR6         1.0     KAHPs6            2.0
   *set_compt_param     CM      0.018
   *set_compt_param     RM      2.5

//APICAL DENDRITE COMPARTMENTS ***************************************
// apdend1 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend1  soma  0  0  75  4      Ca_d6 -1.47129963E17   NaF6        3000   \
                                NaP6         2.4       KDR6        2400   \
                                KA6          160        K26          10   \
                                KM6          380       CaL6           2   \
                                CaH6         80        KCd6         320   \
                                AR6          2.0      KAHPd6         4   
                               
// apdend2 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend2  apdend1  0  0  75  3.8   Ca_d6 -1.54873652E17    NaF6       1500  \
                                    NaP6          1.2     KDR6       1500  \
                                    KA6          80       K26         10   \
                                    KM6         380.8     CaL6         2  \
                                    CaH6         80       KCd6       320  \
                                    AR6           2.0     KAHPd6       4.0


// apdend3 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend3  apdend2  0  0  75  3.6     Ca_d6 -1.63477742E17    NaF6         300  \
                                    NaP6          0.24      KDR6           0  \
                                    KA6           12         K26          10  \
                                    KM6         380.8       CaL6           2  \
                                    CaH6         80         KCd6           10 \
                                    AR6           2.0       KAHPd6         4.0


// apdend4 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend4  apdend3  0  0  75  2.4   Ca_d6  -1.94730587E17  NaF6            300  \
                                    NaP6          0.24     KDR6            0  \
                                    KA6           12        K26             10  \
                                    KM6         380.8      CaL6            2  \
                                    CaH6         80        KCd6            10  \
                                    AR6          2.0      KAHPd6          4.0

// apdend5 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5  apdend4  0  0  75  3.2   Ca_d6  -2.06900497E17     NaF6         300  \
                                    NaP6          0.24      KDR6           0  \
                                    KA6           12         K26          10  \
                                    KM6         380.8       CaL6           2  \
                                    CaH6         40         KCd6           10  \
                                    AR6          2.0       KAHPd6         4.0


// apdend6 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend6  apdend5  0  0  75  3   Ca_d6 -2.20693871E17    NaF6         300  \
                                    NaP6          0.24      KDR6           0  \
                                    KA6           12         K26           10  \
                                    KM6         380.8       CaL6           2  \
                                    CaH6          40         KCd6          10  \
                                    AR6           2.0       KAHPd6         4.0

// apdend7 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend7  apdend6  0  0  75  2.8   Ca_d6 -2.36457724E17     NaF6         300  \
                                    NaP6          0.24     KDR6           0  \
                                    KA6           12        K26          10  \
                                    KM6         380.8      CaL6           2  \
                                    CaH6         40        KCd6           10  \
                                    AR6           2.0      KAHPd6         4.0

// apdend8 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend8  apdend7  0  0  75  2.6   Ca_d6 -2.82942241E17   NaF6         300  \
                                    NaP6         0.24   KDR6           0  \
                                    KA6          12      K26           10  \
                                    KM6        380.8    CaL6           2  \
                                    CaH6        40      KCd6           10  \
                                    AR6          2.0    KAHPd6         4.0

// apdend9 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend9  apdend8  0  0  75  2.4   Ca_d6 -3.06520752E17     NaF6         300   \
                                    NaP6       0.24     KDR6           0   \
                                    KA6        12        K26           10   \
                                    KM6      380.8      CaL6           2   \
                                    CaH6      40        KCd6           10   \
                                    AR6        2.0      KAHPd6         4.0

// apdend10 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend10  apdend9  0  0  75  2   Ca_d6 -4.04611345E17 NaF6           300  \
                                    NaP6       0.24     KDR6           0  \
                                    KA6        12        K26           10  \
                                    KM6      380.8      CaL6           2  \
                                    CaH6      40        KCd6           10  \
                                    AR6        2.0      KAHPd6         4.0

// apdend11 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend11  apdend10  0  0  75  1.6    Ca_d6 -5.51737374E17    NaF6        60  \
                                       NaP6       0.048    KDR6          0  \
                                       KA6        12        K26          10  \
                                       KM6       112        CaL6          2  \
                                       CaH6      20        KCd6          24  \
                                       AR6        2.0      KAHPd6        4.0

// apdend12 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend12  apdend11  0  0  75  1.4    Ca_d6 -6.8309675E17     NaF6         60  \
                                       NaP6         0.048    KDR6          0  \
                                       KA6           12      K26          10  \
                                       KM6          112      CaL6          2  \
                                       CaH6         20       KCd6         24  \
                                       AR6          2.0      KAHPd6        4.0

// apdend13 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend13  apdend12  0  0  75  1.2    Ca_d6 -8.5827204E17    NaF6          60   \
                                       NaP6         0.048   KDR6          0   \
                                       KA6           12     K26           10   \
                                       KM6          112     CaL6          2   \
                                       CaH6         20     KCd6           24   \
                                       AR6           2.0   KAHPd6         4.0

// apdend14aR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14aR  apdend13 11.2 -19.5 55.6 1.1    Ca_d6 -1.00311682E18     NaF6    60  \
                                             NaP6      0.048    KDR6          0  \
                                             KA6       12        K26          10  \
                                             KM6       112        CaL6        2  \
                                             CaH6      54        KCd6         24  \
                                             AR6        4.0      KAHPd6       4.0


// apdend14bR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14bR  apdend14aR 11.2 -19.5 55.6 1.1  Ca_d6 -1.00321358E18  NaF6        60  \
                                             NaP6       0.048    KDR6          0  \
                                             KA6        12        K26         10  \
                                             KM6       112        CaL6         2  \
                                             CaH6      12        KCd6         24  \
                                             AR6       4.0      KAHPd6        4.0

// apdend14cR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14cR  apdend14bR 11.2 -19.5 55.6 1.1    Ca_d6 -1.00321358E18    NaF6     60  \
                                              NaP6      0.048    KDR6          0  \
                                              KA6       12        K26          10  \
                                              KM6       112        CaL6        2  \
                                              CaH6       12       KCd6         24  \
                                              AR6        4.0      KAHPd6       4.0

// apdend14dR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14dR  apdend14cR 11.2 -19.5 55.6 1.1 Ca_d6 -1.00307944E18 NaF6         60  \
                                           NaP6       0.048     KDR6          0  \
                                           KA6       12         K26           10  \
                                           KM6       112         CaL6         2  \
                                           CaH6      12         KCd6         24  \
                                           AR6       4.0       KAHPd6        4.0

// apdend14aL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14aL  apdend13 -11.2 19.5 55.6  1.1    Ca_d6 -1.0030927E18  NaF6         60  \
                                              NaP6      0.048    KDR6          0  \
                                              KA6       12        K26          10   \
                                              KM6       112       CaL6          2  \
                                              CaH6      54        KCd6         24  \
                                              AR6       4.0      KAHPd6        4.0


// apdend14bL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14bL  apdend14aL -11.2 19.5 55.6 1.1  Ca_d6 -1.00322458E18  NaF6        60  \
                                             NaP6      0.048    KDR6          0  \
                                             KA6       12        K26          10  \
                                             KM6       112       CaL6          2  \
                                             CaH6      12        KCd6         24  \
                                             AR6       4.0      KAHPd6        4.0

// apdend14cL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14cL  apdend14bL -11.2 19.5 55.6 1.1    Ca_d6 -1.00322368E18  NaF6       60  \
                                              NaP6      0.048    KDR6          0  \
                                              KA6       12        K26          10  \
                                              KM6       112       CaL6          2  \
                                              CaH6       12        KCd6         24  \
                                              AR6        4.0      KAHPd6        4.0

// apdend14dL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14dL  apdend14cL -11.2 19.5 55.6 1.1 Ca_d6 -1.0030782E18    NaF6        60  \
                                           NaP6       0.048     KDR6          0  \
                                           KA6        12         K26          10  \
                                           KM6       112         CaL6         2  \
                                           CaH6       12         KCd6         24  \
                                           AR6        4.0       KAHPd6        4.0

//APICAL OBLIQUE DENDRITE COMPARTMENTS ***************************************

// apobdistRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRa  apdend3  42.4  42.4 0.0 1.24      Ca_d6 -8.1574073E17 NaF6         1500  \
                                             NaP6        1.2     KDR6          1500  \
                                             KA6        160       K26            10  \
                                             KM6       380.8     CaL6             2  \
                                             CaH6       80       KCd6           320  \
                                             AR6         2.0     KAHPd6          4.0

// apobdistRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRb  apobdistRa  42.4  42.4 0.0 1.24    Ca_d6 -8.1574094E17    NaF6       300  \
                                              NaP6       0.24     KDR6            0  \
                                              KA6        12        K26            10   \
                                              KM6      380.8      CaL6            2  \
                                              CaH6      80        KCd6            10  \
                                              AR6       2.0      KAHPd6          4.0

// apobdistRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRc  apobdistRb  42.4  42.4 0.0 1.24    Ca_d6 -8.1574321E17    NaF6         300  \
                                              NaP6       0.24     KDR6            0  \
                                              KA6        12        K26            10  \
                                              KM6      380.8      CaL6            2  \
                                              CaH6      80        KCd6            10  \
                                              AR6        2.0      KAHPd6          4.0

// apobdistLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLa  apdend3  -42.4  -42.4 0.0 1.24     Ca_d6 -8.1574073E17 NaF6        1500  \
                                               NaP6       1.2     KDR6         1500  \
                                               KA6        160       K26           10  \
                                               KM6       380.8     CaL6           2  \
                                               CaH6       80       KCd6          320  \
                                               AR6        2.0     KAHPd6         4.0

// apobdistLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLb  apobdistLa  -42.4  -42.4 0.0 1.24   Ca_d6 -8.1574094E17    NaF6         300  \
                                                NaP6       0.24     KDR6            0  \
                                                KA6        12        K26            10  \
                                                KM6      380.8      CaL6            2  \
                                                CaH6      80        KCd6            10  \
                                                AR6       2.0      KAHPd6          4.0

// apobdistLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLc  apobdistLb  -42.4 -42.4 0.0 1.24    Ca_d6 -8.1574321E17 NaF6          300  \
                                                NaP6       0.24     KDR6            0  \
                                                KA6        12        K26            10  \
                                                KM6      380.8      CaL6            2  \
                                                CaH6      80        KCd6            10  \
                                                AR6        2.0      KAHPd6         4.0

// apobmidRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidRa  apdend2  42.4  -42.4 0.0  1.24      Ca_d6 -8.1574073E17    NaF6      1500  \
                                              NaP6        1.2     KDR6          1500  \
                                              KA6        160       K26            10  \
                                              KM6       380.8     CaL6            2  \
                                              CaH6       80       KCd6          320  \
                                              AR6         2.0     KAHPd6          4.0

// apobmidRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidRb  apobmidRa  42.4  -42.4 0.0  1.24    Ca_d6 -8.1574094E17    NaF6        300  \
                                               NaP6       0.24     KDR6            0  \
                                               KA6        12        K26            10  \
                                               KM6      380.8      CaL6            2  \
                                               CaH6      80        KCd6            10  \
                                               AR6        2.0      KAHPd6          4.0

// apobmidRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidRc  apobmidRb  42.4  -42.4 0.0  1.24    Ca_d6 -8.1574321E17    NaF6        300  \
                                               NaP6       0.24     KDR6            0  \
                                               KA6        12        K26            10   \
                                               KM6      380.8      CaL6            2  \
                                               CaH6      80        KCd6            10  \
                                               AR6        2.0      KAHPd6          4.0

// apobmidLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidLa  apdend2  -42.4  42.4 0.0  1.24      Ca_d6 -8.1574073E17 NaF6          1500  \
                                              NaP6       1.2      KDR6          1500  \
                                              KA6        160       K26            10  \
                                              KM6       380.8     CaL6             2  \
                                              CaH6       80       KCd6           320  \
                                              AR6        2.0     KAHPd6          4.0

// apobmidLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidLb  apobmidLa  -42.4  42.4 0.0  1.24     Ca_d6 -8.1574094E17   NaF6          300  \
                                               NaP6       0.24     KDR6            0  \
                                               KA6        12        K26            10   \
                                               KM6      380.8      CaL6            2  \
                                               CaH6      80        KCd6            10  \
                                               AR6        2.0      KAHPd6          4.0

// apobmidLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidLc  apobmidLb  -42.4  42.4 0.0  1.24     Ca_d6 -8.1574321E17   NaF6         300  \
                                               NaP6       0.24     KDR6            0  \
                                               KA6        12        K26            10  \
                                               KM6      380.8      CaL6            2  \
                                               CaH6      80        KCd6            10  \
                                               AR6        2.0      KAHPd6          4.0

// apobproxRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRa  apdend1  42.4  42.4 0.0  1.24     Ca_d6 -8.1574073E17 NaF6         1500  \
                                              NaP6        1.2     KDR6         1500  \
                                              KA6        160       K26            10   \
                                              KM6       380.8     CaL6            2  \
                                              CaH6       80       KCd6          320  \
                                              AR6        2.0     KAHPd6          4.0

// apobproxRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRb  apobproxRa  42.4  42.4 0.0  1.24     Ca_d6 -8.1574094E17 NaF6          300  \
                                                NaP6       0.24     KDR6            0  \
                                                KA6        12        K26             10  \
                                                KM6      380.8      CaL6            2  \
                                                CaH6      80        KCd6            10  \
                                                AR6        2.0      KAHPd6          4.0

// apobproxRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRc  apobproxRb  42.4  42.4 0.0  1.24     Ca_d6 -8.1573867E17 NaF6          300  \
                                                NaP6       0.24     KDR6            0  \
                                                KA6        12        K26             10  \
                                                KM6      380.8     CaL6            2  \
                                                CaH6      80        KCd6            10  \
                                                AR6        2.0      KAHPd6          4.0

// apobproxLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLa  apdend1  -42.4  -42.4 0.0  1.24      Ca_d6 -8.1574073E17    NaF6      1500  \
                                                NaP6        1.2     KDR6          1500  \
                                                KA6        160       K26             10  \
                                                KM6       380.8     CaL6            2  \
                                                CaH6       80       KCd6          320  \
                                                AR6        2.0     KAHPd6          4.0

// apobproxLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLb  apobproxLa  -42.4  -42.4 0.0  1.24     Ca_d6 -8.1574094E17 NaF6          300  \
                                                  NaP6       0.24     KDR6            0  \
                                                  KA6        12        K26            10  \
                                                  KM6      380.8      CaL6            2  \
                                                  CaH6      80        KCd6            10  \
                                                  AR6        2.0      KAHPd6          4.0

// apobproxLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLc  apobproxLb  -42.4  -42.4 0.0  1.24     Ca_d6 -8.1573867E17    NaF6          300  \
                                                  NaP6       0.24     KDR6            0  \
                                                  KA6        12        K26             10  \
                                                  KM6      380.8      CaL6            2  \
                                                  CaH6      80        KCd6            10  \
                                                  AR6        2.0      KAHPd6          4.0

//BASAL DENDRITE COMPARTMENTS ************************************************
// basalLsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsupera  soma  -26.8  -46.3  -27.2  1.7    Ca_d6 -5.40919039E17   NaF6     1500  \
                                                NaP6        1.2     KDR6        1500  \
                                                KA6        160       K26          10  \
                                                KM6       380.8     CaL6          2  \
                                                CaH6       80       KCd6        320  \
                                                AR6       2.0     KAHPd6        4.0

// basalLsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsuperb  basalLsupera  -26.8  -46.3 -27.2  1.7     Ca_d6 -5.40918077E17    NaF6      300  \
                                                        NaP6        0.24    KDR6          0  \
                                                        KA6         12      K26          10  \
                                                        KM6       380.8     CaL6          2  \
                                                        CaH6       80       KCd6         10  \
                                                        AR6        2.0     KAHPd6        4.0

// basalLsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsuperc  basalLsuperb  -26.8  -46.3 -27.2  1.7     Ca_d6 -5.40917321E17   NaF6     300  \
                                                        NaP6       0.24     KDR6          0  \
                                                        KA6         12       K26          10  \
                                                        KM6       380.8     CaL6          2  \
                                                        CaH6       80       KCd6          10  \
                                                        AR6        2.0     KAHPd6        4.0

// basalLmida Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmida  soma  -19.3  33.4  -46.0  1.7      Ca_db6 -5.4091897E17    NaF6     1500  \
                                               NaP6       1.2     KDR6        1500  \
                                               KA6        160       K26         10  \
                                               KM6       380.8     CaL6          2  \
                                               CaH6       80       KCdb6        320  \
                                               AR6        2.0     KAHPdb6        4.0

// basalLmidb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmidb  basalLmida  -19.3  33.4 -46.0  1.7         Ca_d6 -5.40919417E17    NaF6    300  \
                                                       NaP6        0.24    KDR6          0  \
                                                       KA6         12       K26         10  \
                                                       KM6       380.8     CaL6          2  \
                                                       CaH6       80       KCd6          10  \
                                                       AR6        2.0     KAHPd6        4.0

// basalLmidc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmidc  basalLmidb  -19.3  33.4 -46.0  1.7         Ca_d6 -5.40919967E17    NaF6    300  \
                                                       NaP6        0.24    KDR6          0  \
                                                       KA6        12       K26           10  \
                                                       KM6       380.8     CaL6          2  \
                                                       CaH6       80       KCd6          10  \
                                                       AR6        2.0     KAHPd6        4.0

// basalRsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsupera  soma  26.8  46.3  -27.2  1.7     Ca_d6 -5.40919039E17    NaF6    1500  \
                                               NaP6      1.2      KDR6        1500  \
                                               KA6       160       K26           10  \
                                               KM6       380.8     CaL6          2  \
                                               CaH6       80       KCd6        320  \
                                               AR6        2.0     KAHPd6       4.0

// basalRsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsuperb  basalRsupera  26.8  46.3 -27.2  1.7      Ca_d6 -5.40919417E17    NaF6    300  \
                                                       NaP6        0.24    KDR6          0  \
                                                       KA6         12       K26          10  \
                                                       KM6       380.8     CaL6          2  \
                                                       CaH6       80       KCd6          10  \
                                                       AR6        2.0     KAHPd6        4.0

// basalRsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsuperc  basalRsuperb  26.8  46.3 -27.2  1.7      Ca_d6  -5.40919967E17    NaF6   300  \
                                                       NaP6        0.24    KDR6          0  \
                                                       KA6        12       K26          10  \
                                                       KM6       380.8     CaL6          2  \
                                                       CaH6       80       KCd6          10  \
                                                       AR6        2.0     KAHPd6       4.0

// basalRmida Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmida  soma  19.3  -33.4  -46.0  1.7       Ca_db6 -5.40918901E17  NaF6      1500  \
                                                NaP6        1.2     KDR6        1500  \
                                                KA6        160       K26         10   \
                                                KM6       380.0     CaL6          2  \
                                                CaH6       80       KCdb6        320  \
                                                AR6        2.0     KAHPdb6        4.0

// basalRmidb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmidb  basalRmida  19.3  -33.4 -46.0  1.7          Ca_d6 -5.40919417E17   NaF6     300  \
                                                        NaP6        0.24    KDR6          0  \
                                                        KA6         12       K26           10  \
                                                        KM6       380.8     CaL6          2  \
                                                        CaH6       80       KCd6          10  \
                                                        AR6         2.0     KAHPd6        4.0

// basalRmidc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmidc  basalRmidb  19.3  -33.4 -46.0  1.7          Ca_d6 -5.4091952E17    NaF6      300  \
                                                        NaP6        0.24    KDR6          0  \
                                                        KA6         12       K26           10  \
                                                        KM6       380.8     CaL6          2  \
                                                        CaH6       80       KCd6          10  \
                                                        AR6        2.0     KAHPd6        4.0

// basaldeepa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basaldeepa  soma  0  0  -60.0  1.7          Ca_db6 -5.40918764E17    NaF6    1500  \
                                            NaP6       1.2      KDR6        1500  \
                                            KA6        160       K26         10    \
                                            KM6       380.8     CaL6          2  \
                                            CaH6       80       KCdb6        320  \
                                            AR6        2.0     KAHPdb6        4.0

// basaldeepb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basaldeepb  basaldeepa  0  0 -60.0  1.7             Ca_d6 -5.40919417E17    NaF6    300  \
                                                    NaP6        0.24    KDR6          0  \
                                                    KA6        12       K26          10  \
                                                    KM6       380.8     CaL6          2  \
                                                    CaH6       80       KCd6          10  \
                                                    AR6         2.0     KAHPd6        4.0

// basaldeepc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basaldeepc  basaldeepb  0  0 -60.0  1.7             Ca_d6 -5.40919967E17    NaF6    300  \
                                                    NaP6        0.24    KDR6          0  \
                                                    KA6         12       K26         10  \
                                                    KM6       380.8     CaL6          2  \
                                                    CaH6       80       KCd6          10  \
                                                    AR6         2.0     KAHPd6        4.0


//		Specifying constants for axonal compartment RMCM=0.0014 (0.0009)
*set_compt_param	RM	0.10   // (0.10)
*set_compt_param	RA	1.00   // (1.00)
*set_compt_param	CM	0.009  // (0.009)
*set_compt_param     EREST_ACT	-0.07 // -0.075
*set_compt_param     ELEAK	-0.066 // -0.075

//AXONAL COMPARTMENTS ***************************************
// axona Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axona  soma  0  0 -25  1.8      NaF6       4500   \
                                NaP6          0.0     KDR6       4500   \
                                KA6           6       K26           5   \
                                KM6         300       CaL6          0   \
                                CaH6          0   \
                                AR6           0   

// axonb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonb  axona  0  0 -50  1.4     NaF6       4500   \
                                NaP6          0.0     KDR6       4500   \
                                KA6           6       K26           5   \
                                KM6         300       CaL6          0   \
                                CaH6          0   \
                                AR6           0

// axonLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLa  axonb  -8.7  0 -49.2  1.0    NaF6       4500   \
                                     NaP6          0.0     KDR6       4500   \
                                     KA6           6       K26           5   \
                                     KM6         300       CaL6          0   \
                                     CaH6          0   \
                                     AR6           0   

// axonLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLb  axonLa  -8.7  0 -49.2  1.0   NaF6       4500   \
                                     NaP6          0.0     KDR6       4500   \
                                     KA6           6       K26           5   \
                                     KM6         300       CaL6          0   \
                                     CaH6          0   \
                                     AR6           0   

// axonRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRa  axonb   8.7  0 -49.2  1.0    NaF6       4500   \
                                     NaP6          0.0     KDR6       4500   \
                                     KA6           6       K26           5   \
                                     KM6         300       CaL6          0   \
                                     CaH6          0   \
                                     AR6           0  

// axonRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRb  axonRa   8.7  0 -49.2  1.0   NaF6       4500   \
                                     NaP6          0.0     KDR6       4500   \
                                     KA6           6       K26           5   \
                                     KM6         300       CaL6          0   \
                                     CaH6          0   \
                                     AR6           0     

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