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A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)

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Accession:206238
A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites. The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
References:
1 . Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. J Neural Eng 12:046016 [PubMed]
2 . Basu I, Kudela P, Anderson WS (2014) Determination of seizure propagation across microdomains using spectral measures of causality. Conf Proc IEEE Eng Med Biol Soc 2014:6349-52 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Thalamus reticular nucleus GABA cell; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron;
Channel(s): I Na,p; I Na,t; I K; I A; I M; I h; I K,Ca; I A, slow; I L high threshold; I T low threshold; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba; Amino Acids;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Epilepsy;
Implementer(s): Anderson, WS ; Kudela, Pawel ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow; Amino Acids; Gaba; Glutamate;
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BasuEtAl2015
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P6RSd_P6RSa.g
P6RSd_P6RSb.g
P6RSd_P6RSc.g
P6RSd_P6RSd.g
P6RSd_P6RSd_Gap.g
P6RSd_raninput.g
P6RSd_ST4RS.g
P6RSd_synapsedefs.g
P6RSd_TCR.g
P6RSdcell3Dpk.p
P6RSdchanpk.g
P6RSdprotodefs.g
P6RSsyncond.g
pgenesis_command
protodefs.g
protospikeB23FS.g
protospikeB5FS.g
protospikeC23FS.g
protospikeC5FS.g
protospikeI23LTS.g
protospikeI5LTS.g
protospikenRT.g
protospikeP23FRBa.g
protospikeP23RSa.g
protospikeP23RSb.g
protospikeP23RSc.g
protospikeP23RSd.g
protospikeP5IBa.g
protospikeP5IBb.g
protospikeP5IBc.g
protospikeP5IBd.g
protospikeP5RSa.g
protospikeP6RSa.g
protospikeP6RSb.g
protospikeP6RSc.g
protospikeP6RSd.g
protospikeST4RS.g
protospikeTCR.g
randominputdefs.g
spikedefs.g
ST4RS.g
ST4RS_B23FS.g
ST4RS_B5FS.g
ST4RS_C23FS.g
ST4RS_C5FS.g
ST4RS_I23LTS.g
ST4RS_I5LTS.g
ST4RS_P23FRBa.g
ST4RS_P23RSa.g
ST4RS_P23RSb.g
ST4RS_P23RSc.g
ST4RS_P23RSd.g
ST4RS_P5IBa.g
ST4RS_P5IBb.g
ST4RS_P5IBc.g
ST4RS_P5IBd.g
ST4RS_P5RSa.g
ST4RS_P6RSa.g
ST4RS_P6RSb.g
ST4RS_P6RSc.g
ST4RS_P6RSd.g
ST4RS_raninput.g
ST4RS_ST4RS.g
ST4RS_ST4RS_Gap.g
ST4RS_synapsedefs.g
ST4RScell3Dpk.p
ST4RSchanpk.g
ST4RSprotodefs.g
ST4RSsyncond.g
synapticdelays.g *
synapticprobsTraub.g
synchansB23FS.g *
synchansB5FS.g *
synchansC23FS.g *
synchansC5FS.g *
synchansI23LTS.g *
synchansI5LTS.g *
synchansnRT.g *
synchansP23FRBa.g *
synchansP23RSa.g *
synchansP23RSb.g *
synchansP23RSc.g *
synchansP23RSd.g *
synchansP5IBa.g *
synchansP5IBb.g *
synchansP5IBc.g *
synchansP5IBd.g *
synchansP5RSa.g *
synchansP6RSa.g *
synchansP6RSb.g *
synchansP6RSc.g *
synchansP6RSd.g *
synchansSPIKEs.g *
synchansSPIKEs_base.g
synchansST4RS.g
synchansTCR.g *
syncond.g
syncond2.g
TCR.g
TCR_B23FS.g
TCR_B5FS.g
TCR_C23FS.g
TCR_C5FS.g
TCR_nRT.g
TCR_P23FRBa.g
TCR_P23RSa.g
TCR_P23RSb.g
TCR_P23RSc.g
TCR_P23RSd.g
TCR_P5IBa.g
TCR_P5IBb.g
TCR_P5IBc.g
TCR_P5IBd.g
TCR_P5RSa.g
TCR_P6RSa.g
TCR_P6RSb.g
TCR_P6RSc.g
TCR_P6RSd.g
TCR_raninput.g
TCR_ST4RS.g
TCR_synapsedefs.g
TCRcellpk.p
TCRchanpk.g
TCRprotodefs.g
TCRsyncond.g
                            
// P5IBb.p - for TraubIB_VP

//	Format of file :
// x,y,z,dia are in microns, all other units are SI (Meter Kilogram Sec Amp)
// In polar mode 'r' is in microns, theta and phi in degrees 
// Control line options start with a '*'
// The format for each compartment parameter line is :
//name	parent	r	theta	phi	d	ch	dens ...
//in polar mode, and in cartesian mode :
//name	parent	x	y	z	d	ch	dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment
// For spike elements, "dens" is the spike threshold
//		Coordinate mode
*relative
*cartesian
*asymmetric

//		Specifying constants
   *set_compt_param	RM	5.0   // 5.0
   *set_compt_param	RA	2.50  // 2.50
   *set_compt_param	CM	0.009 // 0.009
   *set_compt_param     EREST_ACT	-0.07 // -0.075
   *set_compt_param     ELEAK           -0.0666 // -0.075


//SOMA *************************************************************   
// For the soma, use the leakage potential (-0.07 + 0.0106) for Em
//*set_compt_param     ELEAK	-0.0594
// Actually, after Traub et al. J Neurophys 2003;89:909-921, will maintain
// leakage potential at ELEAK   -0.07
soma  none   0  0  15  18     Ca_s7 -6.1304081E14 NaF7           2000     \
                              NaP7        1.6     KDR7           1700     \
                              KA7         200     K27               5     \
                              KM7         119     CaL7              1     \
                              CaH7         40     KCs7            160     \
                              AR7         1.0     KAHPs7            2.0
   *set_compt_param     CM      0.018
   *set_compt_param     RM      2.5

//APICAL DENDRITE COMPARTMENTS ***************************************
// apdend1 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend1  soma  0  0  75  4      Ca_d7 -1.47129963E17   NaF7        3000   \
                                NaP7         2.4       KDR7        2400   \
                                KA7          160        K27          10   \
                                KM7          380       CaL7           2   \
                                CaH7         80        KCd7         320   \
                                AR7          2.0      KAHPd7         4   
                               
// apdend2 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend2  apdend1  0  0  75  3.8   Ca_d7 -1.54873652E17    NaF7       1500  \
                                    NaP7          1.2     KDR7       1500  \
                                    KA7          80       K27         10   \
                                    KM7         380.8     CaL7         2  \
                                    CaH7         80       KCd7       320  \
                                    AR7           2.0     KAHPd7       4.0


// apdend3 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend3  apdend2  0  0  75  3.6     Ca_d7 -1.63477742E17    NaF7         300  \
                                    NaP7          0.24      KDR7           0  \
                                    KA7           12         K27          10  \
                                    KM7         380.8       CaL7           2  \
                                    CaH7         80         KCd7           10 \
                                    AR7           2.0       KAHPd7         4.0


// apdend4 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend4  apdend3  0  0  75  2.4   Ca_d7  -1.94730587E17  NaF7            300  \
                                    NaP7          0.24     KDR7            0  \
                                    KA7           12        K27             10  \
                                    KM7         380.8      CaL7            2  \
                                    CaH7         80        KCd7            10  \
                                    AR7          2.0      KAHPd7          4.0

// apdend5 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend5  apdend4  0  0  75  3.2   Ca_d7  -2.06900497E17     NaF7         300  \
                                    NaP7          0.24      KDR7           0  \
                                    KA7           12         K27          10  \
                                    KM7         380.8       CaL7           2  \
                                    CaH7         40         KCd7           10  \
                                    AR7          2.0       KAHPd7         4.0


// apdend6 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend6  apdend5  0  0  75  3   Ca_d7 -2.20693871E17    NaF7         300  \
                                    NaP7          0.24      KDR7           0  \
                                    KA7           12         K27           10  \
                                    KM7         380.8       CaL7           2  \
                                    CaH7          40         KCd7          10  \
                                    AR7           2.0       KAHPd7         4.0

// apdend7 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend7  apdend6  0  0  75  2.8   Ca_d7 -2.36457724E17     NaF7         300  \
                                    NaP7          0.24     KDR7           0  \
                                    KA7           12        K27          10  \
                                    KM7         380.8      CaL7           2  \
                                    CaH7         40        KCd7           10  \
                                    AR7           2.0      KAHPd7         4.0

// apdend8 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend8  apdend7  0  0  75  2.6   Ca_d7 -2.82942241E17   NaF7         300  \
                                    NaP7         0.24   KDR7           0  \
                                    KA7          12      K27           10  \
                                    KM7        380.8    CaL7           2  \
                                    CaH7        40      KCd7           10  \
                                    AR7          2.0    KAHPd7         4.0

// apdend9 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend9  apdend8  0  0  75  2.4   Ca_d7 -3.06520752E17     NaF7         300   \
                                    NaP7       0.24     KDR7           0   \
                                    KA7        12        K27           10   \
                                    KM7      380.8      CaL7           2   \
                                    CaH7      40        KCd7           10   \
                                    AR7        2.0      KAHPd7         4.0

// apdend10 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend10  apdend9  0  0  75  2   Ca_d7 -4.04611345E17 NaF7           300  \
                                    NaP7       0.24     KDR7           0  \
                                    KA7        12        K27           10  \
                                    KM7      380.8      CaL7           2  \
                                    CaH7      40        KCd7           10  \
                                    AR7        2.0      KAHPd7         4.0

// apdend11 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend11  apdend10  0  0  75  1.6    Ca_d7 -5.51737374E17    NaF7        60  \
                                       NaP7       0.048    KDR7          0  \
                                       KA7        12        K27          10  \
                                       KM7       112        CaL7          2  \
                                       CaH7      20        KCd7          24  \
                                       AR7        2.0      KAHPd7        4.0

// apdend12 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend12  apdend11  0  0  75  1.4    Ca_d7 -6.8309675E17     NaF7         60  \
                                       NaP7         0.048    KDR7          0  \
                                       KA7           12      K27          10  \
                                       KM7          112      CaL7          2  \
                                       CaH7         20       KCd7         24  \
                                       AR7          2.0      KAHPd7        4.0

// apdend13 Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend13  apdend12  0  0  75  1.2    Ca_d7 -8.5827204E17    NaF7          60   \
                                       NaP7         0.048   KDR7          0   \
                                       KA7           12     K27           10   \
                                       KM7          112     CaL7          2   \
                                       CaH7         20     KCd7           24   \
                                       AR7           2.0   KAHPd7         4.0

// apdend14aR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14aR  apdend13 11.2 -19.5 55.6 1.1    Ca_d7 -1.00311682E18     NaF7    60  \
                                             NaP7      0.048    KDR7          0  \
                                             KA7       12        K27          10  \
                                             KM7       112        CaL7        2  \
                                             CaH7      54        KCd7         24  \
                                             AR7        4.0      KAHPd7       4.0


// apdend14bR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14bR  apdend14aR 11.2 -19.5 55.6 1.1  Ca_d7 -1.00321358E18  NaF7        60  \
                                             NaP7       0.048    KDR7          0  \
                                             KA7        12        K27         10  \
                                             KM7       112        CaL7         2  \
                                             CaH7      12        KCd7         24  \
                                             AR7       4.0      KAHPd7        4.0

// apdend14cR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14cR  apdend14bR 11.2 -19.5 55.6 1.1    Ca_d7 -1.00321358E18    NaF7     60  \
                                              NaP7      0.048    KDR7          0  \
                                              KA7       12        K27          10  \
                                              KM7       112        CaL7        2  \
                                              CaH7       12       KCd7         24  \
                                              AR7        4.0      KAHPd7       4.0

// apdend14dR Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14dR  apdend14cR 11.2 -19.5 55.6 1.1 Ca_d7 -1.00307944E18 NaF7         60  \
                                           NaP7       0.048     KDR7          0  \
                                           KA7       12         K27           10  \
                                           KM7       112         CaL7         2  \
                                           CaH7      12         KCd7         24  \
                                           AR7       4.0       KAHPd7        4.0

// apdend14aL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14aL  apdend13 -11.2 19.5 55.6  1.1    Ca_d7 -1.0030927E18  NaF7         60  \
                                              NaP7      0.048    KDR7          0  \
                                              KA7       12        K27          10   \
                                              KM7       112       CaL7          2  \
                                              CaH7      54        KCd7         24  \
                                              AR7       4.0      KAHPd7        4.0


// apdend14bL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14bL  apdend14aL -11.2 19.5 55.6 1.1  Ca_d7 -1.00322458E18  NaF7        60  \
                                             NaP7      0.048    KDR7          0  \
                                             KA7       12        K27          10  \
                                             KM7       112       CaL7          2  \
                                             CaH7      12        KCd7         24  \
                                             AR7       4.0      KAHPd7        4.0

// apdend14cL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14cL  apdend14bL -11.2 19.5 55.6 1.1    Ca_d7 -1.00322368E18  NaF7       60  \
                                              NaP7      0.048    KDR7          0  \
                                              KA7       12        K27          10  \
                                              KM7       112       CaL7          2  \
                                              CaH7       12        KCd7         24  \
                                              AR7        4.0      KAHPd7        4.0

// apdend14dL Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apdend14dL  apdend14cL -11.2 19.5 55.6 1.1 Ca_d7 -1.0030782E18    NaF7        60  \
                                           NaP7       0.048     KDR7          0  \
                                           KA7        12         K27          10  \
                                           KM7       112         CaL7         2  \
                                           CaH7       12         KCd7         24  \
                                           AR7        4.0       KAHPd7        4.0

//APICAL OBLIQUE DENDRITE COMPARTMENTS ***************************************

// apobdistRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRa  apdend3  42.4  42.4 0.0 1.24      Ca_d7 -8.1574073E17 NaF7         1500  \
                                             NaP7        1.2     KDR7          1500  \
                                             KA7        160       K27            10  \
                                             KM7       380.8     CaL7             2  \
                                             CaH7       80       KCd7           320  \
                                             AR7         2.0     KAHPd7          4.0

// apobdistRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRb  apobdistRa  42.4  42.4 0.0 1.24    Ca_d7 -8.1574094E17    NaF7       300  \
                                              NaP7       0.24     KDR7            0  \
                                              KA7        12        K27            10   \
                                              KM7      380.8      CaL7            2  \
                                              CaH7      80        KCd7            10  \
                                              AR7       2.0      KAHPd7          4.0

// apobdistRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistRc  apobdistRb  42.4  42.4 0.0 1.24    Ca_d7 -8.1574321E17    NaF7         300  \
                                              NaP7       0.24     KDR7            0  \
                                              KA7        12        K27            10  \
                                              KM7      380.8      CaL7            2  \
                                              CaH7      80        KCd7            10  \
                                              AR7        2.0      KAHPd7          4.0

// apobdistLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLa  apdend3  -42.4  -42.4 0.0 1.24     Ca_d7 -8.1574073E17 NaF7        1500  \
                                               NaP7       1.2     KDR7         1500  \
                                               KA7        160       K27           10  \
                                               KM7       380.8     CaL7           2  \
                                               CaH7       80       KCd7          320  \
                                               AR7        2.0     KAHPd7         4.0

// apobdistLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLb  apobdistLa  -42.4  -42.4 0.0 1.24   Ca_d7 -8.1574094E17    NaF7         300  \
                                                NaP7       0.24     KDR7            0  \
                                                KA7        12        K27            10  \
                                                KM7      380.8      CaL7            2  \
                                                CaH7      80        KCd7            10  \
                                                AR7       2.0      KAHPd7          4.0

// apobdistLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobdistLc  apobdistLb  -42.4 -42.4 0.0 1.24    Ca_d7 -8.1574321E17 NaF7          300  \
                                                NaP7       0.24     KDR7            0  \
                                                KA7        12        K27            10  \
                                                KM7      380.8      CaL7            2  \
                                                CaH7      80        KCd7            10  \
                                                AR7        2.0      KAHPd7         4.0

// apobmidRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidRa  apdend2  42.4  -42.4 0.0  1.24      Ca_d7 -8.1574073E17    NaF7      1500  \
                                              NaP7        1.2     KDR7          1500  \
                                              KA7        160       K27            10  \
                                              KM7       380.8     CaL7            2  \
                                              CaH7       80       KCd7          320  \
                                              AR7         2.0     KAHPd7          4.0

// apobmidRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidRb  apobmidRa  42.4  -42.4 0.0  1.24    Ca_d7 -8.1574094E17    NaF7        300  \
                                               NaP7       0.24     KDR7            0  \
                                               KA7        12        K27            10  \
                                               KM7      380.8      CaL7            2  \
                                               CaH7      80        KCd7            10  \
                                               AR7        2.0      KAHPd7          4.0

// apobmidRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidRc  apobmidRb  42.4  -42.4 0.0  1.24    Ca_d7 -8.1574321E17    NaF7        300  \
                                               NaP7       0.24     KDR7            0  \
                                               KA7        12        K27            10   \
                                               KM7      380.8      CaL7            2  \
                                               CaH7      80        KCd7            10  \
                                               AR7        2.0      KAHPd7          4.0

// apobmidLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidLa  apdend2  -42.4  42.4 0.0  1.24      Ca_d7 -8.1574073E17 NaF7          1500  \
                                              NaP7       1.2      KDR7          1500  \
                                              KA7        160       K27            10  \
                                              KM7       380.8     CaL7             2  \
                                              CaH7       80       KCd7           320  \
                                              AR7        2.0     KAHPd7          4.0

// apobmidLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidLb  apobmidLa  -42.4  42.4 0.0  1.24     Ca_d7 -8.1574094E17   NaF7          300  \
                                               NaP7       0.24     KDR7            0  \
                                               KA7        12        K27            10   \
                                               KM7      380.8      CaL7            2  \
                                               CaH7      80        KCd7            10  \
                                               AR7        2.0      KAHPd7          4.0

// apobmidLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobmidLc  apobmidLb  -42.4  42.4 0.0  1.24     Ca_d7 -8.1574321E17   NaF7         300  \
                                               NaP7       0.24     KDR7            0  \
                                               KA7        12        K27            10  \
                                               KM7      380.8      CaL7            2  \
                                               CaH7      80        KCd7            10  \
                                               AR7        2.0      KAHPd7          4.0

// apobproxRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRa  apdend1  42.4  42.4 0.0  1.24     Ca_d7 -8.1574073E17 NaF7         1500  \
                                              NaP7        1.2     KDR7         1500  \
                                              KA7        160       K27            10   \
                                              KM7       380.8     CaL7            2  \
                                              CaH7       80       KCd7          320  \
                                              AR7        2.0     KAHPd7          4.0

// apobproxRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRb  apobproxRa  42.4  42.4 0.0  1.24     Ca_d7 -8.1574094E17 NaF7          300  \
                                                NaP7       0.24     KDR7            0  \
                                                KA7        12        K27             10  \
                                                KM7      380.8      CaL7            2  \
                                                CaH7      80        KCd7            10  \
                                                AR7        2.0      KAHPd7          4.0

// apobproxRc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxRc  apobproxRb  42.4  42.4 0.0  1.24     Ca_d7 -8.1573867E17 NaF7          300  \
                                                NaP7       0.24     KDR7            0  \
                                                KA7        12        K27             10  \
                                                KM7      380.8     CaL7            2  \
                                                CaH7      80        KCd7            10  \
                                                AR7        2.0      KAHPd7          4.0

// apobproxLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLa  apdend1  -42.4  -42.4 0.0  1.24      Ca_d7 -8.1574073E17    NaF7      1500  \
                                                NaP7        1.2     KDR7          1500  \
                                                KA7        160       K27             10  \
                                                KM7       380.8     CaL7            2  \
                                                CaH7       80       KCd7          320  \
                                                AR7        2.0     KAHPd7          4.0

// apobproxLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLb  apobproxLa  -42.4  -42.4 0.0  1.24     Ca_d7 -8.1574094E17 NaF7          300  \
                                                  NaP7       0.24     KDR7            0  \
                                                  KA7        12        K27            10  \
                                                  KM7      380.8      CaL7            2  \
                                                  CaH7      80        KCd7            10  \
                                                  AR7        2.0      KAHPd7          4.0

// apobproxLc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
apobproxLc  apobproxLb  -42.4  -42.4 0.0  1.24     Ca_d7 -8.1573867E17    NaF7          300  \
                                                  NaP7       0.24     KDR7            0  \
                                                  KA7        12        K27             10  \
                                                  KM7      380.8      CaL7            2  \
                                                  CaH7      80        KCd7            10  \
                                                  AR7        2.0      KAHPd7          4.0

//BASAL DENDRITE COMPARTMENTS ************************************************
// basalLsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsupera  soma  -26.8  -46.3  -27.2  1.7    Ca_d7 -5.40919039E17   NaF7     1500  \
                                                NaP7        1.2     KDR7        1500  \
                                                KA7        160       K27          10  \
                                                KM7       380.8     CaL7          2  \
                                                CaH7       80       KCd7        320  \
                                                AR7       2.0     KAHPd7        4.0

// basalLsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsuperb  basalLsupera  -26.8  -46.3 -27.2  1.7     Ca_d7 -5.40918077E17    NaF7      300  \
                                                        NaP7        0.24    KDR7          0  \
                                                        KA7         12      K27          10  \
                                                        KM7       380.8     CaL7          2  \
                                                        CaH7       80       KCd7         10  \
                                                        AR7        2.0     KAHPd7        4.0

// basalLsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLsuperc  basalLsuperb  -26.8  -46.3 -27.2  1.7     Ca_d7 -5.40917321E17   NaF7     300  \
                                                        NaP7       0.24     KDR7          0  \
                                                        KA7         12       K27          10  \
                                                        KM7       380.8     CaL7          2  \
                                                        CaH7       80       KCd7          10  \
                                                        AR7        2.0     KAHPd7        4.0

// basalLmida Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmida  soma  -19.3  33.4  -46.0  1.7      Ca_db7 -5.4091897E17    NaF7     1500  \
                                               NaP7       1.2     KDR7        1500  \
                                               KA7        160       K27         10  \
                                               KM7       380.8     CaL7          2  \
                                               CaH7       80       KCdb7        320  \
                                               AR7        2.0     KAHPdb7        4.0

// basalLmidb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmidb  basalLmida  -19.3  33.4 -46.0  1.7         Ca_d7 -5.40919417E17    NaF7    300  \
                                                       NaP7        0.24    KDR7          0  \
                                                       KA7         12       K27         10  \
                                                       KM7       380.8     CaL7          2  \
                                                       CaH7       80       KCd7          10  \
                                                       AR7        2.0     KAHPd7        4.0

// basalLmidc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalLmidc  basalLmidb  -19.3  33.4 -46.0  1.7         Ca_d7 -5.40919967E17    NaF7    300  \
                                                       NaP7        0.24    KDR7          0  \
                                                       KA7        12       K27           10  \
                                                       KM7       380.8     CaL7          2  \
                                                       CaH7       80       KCd7          10  \
                                                       AR7        2.0     KAHPd7        4.0

// basalRsupera Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsupera  soma  26.8  46.3  -27.2  1.7     Ca_d7 -5.40919039E17    NaF7    1500  \
                                               NaP7      1.2      KDR7        1500  \
                                               KA7       160       K27           10  \
                                               KM7       380.8     CaL7          2  \
                                               CaH7       80       KCd7        320  \
                                               AR7        2.0     KAHPd7       4.0

// basalRsuperb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsuperb  basalRsupera  26.8  46.3 -27.2  1.7      Ca_d7 -5.40919417E17    NaF7    300  \
                                                       NaP7        0.24    KDR7          0  \
                                                       KA7         12       K27          10  \
                                                       KM7       380.8     CaL7          2  \
                                                       CaH7       80       KCd7          10  \
                                                       AR7        2.0     KAHPd7        4.0

// basalRsuperc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRsuperc  basalRsuperb  26.8  46.3 -27.2  1.7      Ca_d7  -5.40919967E17    NaF7   300  \
                                                       NaP7        0.24    KDR7          0  \
                                                       KA7        12       K27          10  \
                                                       KM7       380.8     CaL7          2  \
                                                       CaH7       80       KCd7          10  \
                                                       AR7        2.0     KAHPd7       4.0

// basalRmida Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmida  soma  19.3  -33.4  -46.0  1.7       Ca_db7 -5.40918901E17  NaF7      1500  \
                                                NaP7        1.2     KDR7        1500  \
                                                KA7        160       K27         10   \
                                                KM7       380.0     CaL7          2  \
                                                CaH7       80       KCdb7        320  \
                                                AR7        2.0     KAHPdb7        4.0

// basalRmidb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmidb  basalRmida  19.3  -33.4 -46.0  1.7          Ca_d7 -5.40919417E17   NaF7     300  \
                                                        NaP7        0.24    KDR7          0  \
                                                        KA7         12       K27           10  \
                                                        KM7       380.8     CaL7          2  \
                                                        CaH7       80       KCd7          10  \
                                                        AR7         2.0     KAHPd7        4.0

// basalRmidc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basalRmidc  basalRmidb  19.3  -33.4 -46.0  1.7          Ca_d7 -5.4091952E17    NaF7      300  \
                                                        NaP7        0.24    KDR7          0  \
                                                        KA7         12       K27           10  \
                                                        KM7       380.8     CaL7          2  \
                                                        CaH7       80       KCd7          10  \
                                                        AR7        2.0     KAHPd7        4.0

// basaldeepa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basaldeepa  soma  0  0  -60.0  1.7          Ca_db7 -5.40918764E17    NaF7    1500  \
                                            NaP7       1.2      KDR7        1500  \
                                            KA7        160       K27         10    \
                                            KM7       380.8     CaL7          2  \
                                            CaH7       80       KCdb7        320  \
                                            AR7        2.0     KAHPdb7        4.0

// basaldeepb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basaldeepb  basaldeepa  0  0 -60.0  1.7             Ca_d7 -5.40919417E17    NaF7    300  \
                                                    NaP7        0.24    KDR7          0  \
                                                    KA7        12       K27          10  \
                                                    KM7       380.8     CaL7          2  \
                                                    CaH7       80       KCd7          10  \
                                                    AR7         2.0     KAHPd7        4.0

// basaldeepc Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
basaldeepc  basaldeepb  0  0 -60.0  1.7             Ca_d7 -5.40919967E17    NaF7    300  \
                                                    NaP7        0.24    KDR7          0  \
                                                    KA7         12       K27         10  \
                                                    KM7       380.8     CaL7          2  \
                                                    CaH7       80       KCd7          10  \
                                                    AR7         2.0     KAHPd7        4.0


//		Specifying constants for axonal compartment RMCM=0.0014 (0.0009)
*set_compt_param	RM	0.10   // (0.10)
*set_compt_param	RA	1.00   // (1.00)
*set_compt_param	CM	0.009  // (0.009)
*set_compt_param     EREST_ACT	-0.07 // -0.075
*set_compt_param     ELEAK	-0.066 // -0.075

//AXONAL COMPARTMENTS ***************************************
// axona Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axona  soma  0  0 -25  1.8      NaF7       4500   \
                                NaP7          0.0     KDR7       4500   \
                                KA7           6       K27           5   \
                                KM7         300       CaL7          0   \
                                CaH7          0   \
                                AR7           0   

// axonb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonb  axona  0  0 -50  1.4     NaF7       4500   \
                                NaP7          0.0     KDR7       4500   \
                                KA7           6       K27           5   \
                                KM7         300       CaL7          0   \
                                CaH7          0   \
                                AR7           0

// axonLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLa  axonb  -8.7  0 -49.2  1.0    NaF7       4500   \
                                     NaP7          0.0     KDR7       4500   \
                                     KA7           6       K27           5   \
                                     KM7         300       CaL7          0   \
                                     CaH7          0   \
                                     AR7           0   

// axonLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLb  axonLa  -8.7  0 -49.2  1.0   NaF7       4500   \
                                     NaP7          0.0     KDR7       4500   \
                                     KA7           6       K27           5   \
                                     KM7         300       CaL7          0   \
                                     CaH7          0   \
                                     AR7           0   

// axonRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRa  axonb   8.7  0 -49.2  1.0    NaF7       4500   \
                                     NaP7          0.0     KDR7       4500   \
                                     KA7           6       K27           5   \
                                     KM7         300       CaL7          0   \
                                     CaH7          0   \
                                     AR7           0  

// axonRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRb  axonRa   8.7  0 -49.2  1.0   NaF7       4500   \
                                     NaP7          0.0     KDR7       4500   \
                                     KA7           6       K27           5   \
                                     KM7         300       CaL7          0   \
                                     CaH7          0   \
                                     AR7           0     

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