A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)

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Accession:206238
A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites. The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
References:
1 . Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. J Neural Eng 12:046016 [PubMed]
2 . Basu I, Kudela P, Anderson WS (2014) Determination of seizure propagation across microdomains using spectral measures of causality. Conf Proc IEEE Eng Med Biol Soc 2014:6349-52 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Thalamus reticular nucleus GABA cell; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron;
Channel(s): I Na,p; I Na,t; I K; I A; I M; I h; I K,Ca; I A, slow; I L high threshold; I T low threshold; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba; Amino Acids;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Epilepsy;
Implementer(s): Anderson, WS ; Kudela, Pawel ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow; Amino Acids; Gaba; Glutamate;
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BasuEtAl2015
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ModelDescription.pdf
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P6RSd_P6RSc.g
P6RSd_P6RSd.g
P6RSd_P6RSd_Gap.g
P6RSd_raninput.g
P6RSd_ST4RS.g
P6RSd_synapsedefs.g
P6RSd_TCR.g
P6RSdcell3Dpk.p
P6RSdchanpk.g
P6RSdprotodefs.g
P6RSsyncond.g
pgenesis_command
protodefs.g
protospikeB23FS.g
protospikeB5FS.g
protospikeC23FS.g
protospikeC5FS.g
protospikeI23LTS.g
protospikeI5LTS.g
protospikenRT.g
protospikeP23FRBa.g
protospikeP23RSa.g
protospikeP23RSb.g
protospikeP23RSc.g
protospikeP23RSd.g
protospikeP5IBa.g
protospikeP5IBb.g
protospikeP5IBc.g
protospikeP5IBd.g
protospikeP5RSa.g
protospikeP6RSa.g
protospikeP6RSb.g
protospikeP6RSc.g
protospikeP6RSd.g
protospikeST4RS.g
protospikeTCR.g
randominputdefs.g
spikedefs.g
ST4RS.g
ST4RS_B23FS.g
ST4RS_B5FS.g
ST4RS_C23FS.g
ST4RS_C5FS.g
ST4RS_I23LTS.g
ST4RS_I5LTS.g
ST4RS_P23FRBa.g
ST4RS_P23RSa.g
ST4RS_P23RSb.g
ST4RS_P23RSc.g
ST4RS_P23RSd.g
ST4RS_P5IBa.g
ST4RS_P5IBb.g
ST4RS_P5IBc.g
ST4RS_P5IBd.g
ST4RS_P5RSa.g
ST4RS_P6RSa.g
ST4RS_P6RSb.g
ST4RS_P6RSc.g
ST4RS_P6RSd.g
ST4RS_raninput.g
ST4RS_ST4RS.g
ST4RS_ST4RS_Gap.g
ST4RS_synapsedefs.g
ST4RScell3Dpk.p
ST4RSchanpk.g
ST4RSprotodefs.g
ST4RSsyncond.g
synapticdelays.g *
synapticprobsTraub.g
synchansB23FS.g *
synchansB5FS.g *
synchansC23FS.g *
synchansC5FS.g *
synchansI23LTS.g *
synchansI5LTS.g *
synchansnRT.g *
synchansP23FRBa.g *
synchansP23RSa.g *
synchansP23RSb.g *
synchansP23RSc.g *
synchansP23RSd.g *
synchansP5IBa.g *
synchansP5IBb.g *
synchansP5IBc.g *
synchansP5IBd.g *
synchansP5RSa.g *
synchansP6RSa.g *
synchansP6RSb.g *
synchansP6RSc.g *
synchansP6RSd.g *
synchansSPIKEs.g *
synchansSPIKEs_base.g
synchansST4RS.g
synchansTCR.g *
syncond.g
syncond2.g
TCR.g
TCR_B23FS.g
TCR_B5FS.g
TCR_C23FS.g
TCR_C5FS.g
TCR_nRT.g
TCR_P23FRBa.g
TCR_P23RSa.g
TCR_P23RSb.g
TCR_P23RSc.g
TCR_P23RSd.g
TCR_P5IBa.g
TCR_P5IBb.g
TCR_P5IBc.g
TCR_P5IBd.g
TCR_P5RSa.g
TCR_P6RSa.g
TCR_P6RSb.g
TCR_P6RSc.g
TCR_P6RSd.g
TCR_raninput.g
TCR_ST4RS.g
TCR_synapsedefs.g
TCRcellpk.p
TCRchanpk.g
TCRprotodefs.g
TCRsyncond.g
                            
// P6RSacell3D.p

//      Format of file :
// x,y,z,dia are in microns, all other units are SI (Meter Kilogram Sec Amp)
// In polar mode 'r' is in microns, theta and phi in degrees
// Control line options start with a '*'
// The format for each compartment parameter line is :
//name  parent  r       theta   phi     d       ch      dens ...
//in polar mode, and in cartesian mode :
//name  parent  x       y       z       d       ch      dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment
// For spike elements, "dens" is the spike threshold
//              Coordinate mode
*absolute
*relative
*cartesian
*asymmetric

*set_global              RM     0.3333333
*set_global              EREST_ACT      -0.07
*set_compt_param     ELEAK      -0.0594


//              Specifying constants
*set_compt_param        RM      5.0  //0.33333
*set_compt_param        RA      2.50  //0.3
*set_compt_param        CM      0.009 //0.01
*set_compt_param        ELEAK   -0.0666 // -0.068


//SOMA *************************************************************
// For the soma, use the leakage potential (-0.07 + 0.0106) for Em
//*set_compt_param     ELEAK    -0.0594
// Actually, after Traub et al. J Neurophys 2003;89:909-921, will maintain
soma  none   0  0  15  16     Ca_s11 -2.58626798e15    NaF11       2000   \
                              NaP11        0.8         KDR11       1700   \
                              KA11        1190         K211           1.0 \
                              KM11        42           CaL11          1.0 \
                              CaH11        2.0         KCs11        150   \
                              AR11         2.5         KAHPs11        2.0  
*set_compt_param     RA 2.5
*set_compt_param     CM 0.018
*set_compt_param     ELEAK -0.0666
*set_compt_param     RM 2.5


//APICAL DENDRITE COMPARTMENTS ***************************************
// apdend1 Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend1  soma  0  0  50 3       Ca_d11 -1.65521236e17     NaF11       3000   \
                                NaP11        1.2          KDR11       2400   \
                                KA11      2380            K211           2   \
                                KM11        84            CaL11          2   \
                                CaH11        4            KCd11        300   \
                                AR11         5          KAHPd11        4.0

// apdend2 Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend2  apdend1  0  0  50   2.8    Ca_d11 -1.88092836e17 NaF11   1500  \
                                    NaP11        0.6     KDR11   1500  \
                                    KA11        272       K211      2  \
                                    KM11        84       CaL11     4  \
                                    CaH11        2       KCd11   300  \
                                    AR11         5     KAHPd11   4.0


// apdend3 Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend3  apdend2  0  0  50   2.8   Ca_d11 -2.22818969E17  NaF11   100  \
                                    NaP11       0.04     KDR11    0  \
                                    KA11      272        K211     2  \
                                    KM11       84        CaL11    2  \
                                    CaH11       4        KCd11    0  \
                                    AR11        5        KAHPd11  4.0


// apdend4 Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend4  apdend3  0  0  50   2.6    Ca_d11 -2.22818969e17    NaF11          100  \
                                    NaP11       0.04         KDR11           0  \
                                    KA11      272            K211            2  \
                                    KM11       84            CaL11           2  \
                                    CaH11       4            KCd11           0  \
                                    AR11        5            KAHPd11         4.0

// apdend5 Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend5  apdend4  0  0  50   2.40  Ca_d11    -2.41385133e17  NaF11	    100 \
                                    NaP11       0.04         KDR11           0  \
                                    KA11      272            K211            2  \
                                    KM11       84            CaL11           2  \
                                    CaH11       4            KCd11           0  \
                                    AR11        5            KAHPd11         4.0

// apdend6 Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend6  apdend5  0  0  50   2      Ca_d11 -3.31042301e17    NaF11          100  \
                                    NaP11       0.04         KDR11           0  \
                                    KA11      272            K211            2  \
                                    KM11       84            CaL11           2  \
                                    CaH11       40           KCd11           0  \
                                    AR11        5            KAHPd11         4.0

// apdend7  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend7  apdend6  0  0  50   1.8    Ca_d11 -3.67824744e17    NaF11          100  \
                                    NaP11       0.04         KDR11           0  \
                                    KA11      272            K211            2  \
                                    KM11       84            CaL11           2  \
                                    CaH11       40           KCd11           0  \
                                    AR11        5            KAHPd11         4.0

// apdend8  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend8  apdend7  0  0  50   1.6    Ca_d11 -4.1380285e17     NaF11          100  \
                                    NaP11         0.04       KDR11           0  \
                                    KA11        272          K211            2  \
                                    KM11         84          CaL11           2  \
                                    CaH11         40         KCd11           0  \
                                    AR11          5        KAHPd11         4.0

// apdend9  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend9  apdend8  0  0  50   1.4    Ca_d11 -5.32033542e17    NaF11          100   \
                                    NaP11       0.04         KDR11           0   \
                                    KA11      272            K211            2   \
                                    KM11       84            CaL11           2   \
                                    CaH11       40           KCd11           0   \
                                    AR11        5            KAHPd11         4.0

// apdend10  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apdend10  apdend9  0  0  40   1.2   Ca_d11  -6.8967142e17    NaF11          100  \
                                    NaP11       0.04         KDR11           0  \
                                    KA11      272            K211            2  \
                                    KM11       84            CaL11           2  \
                                    CaH11       40           KCd11           0  \
                                    AR11        5            KAHPd11         4.0

//APICAL OBLIQUE DENDRITE COMPARTMENTS ***************************************

// apobdistRa  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobdistRa  apdend3  42.4  42.4 0  1.24      Ca_d11 -6.1180627e17     NaF11      1500  \
                                             NaP11        0.6         KDR11      1500  \
                                             KA11       272           K211         2  \
                                             KM11        84           CaL11        2  \
                                             CaH11        4           KCd11      300  \
                                             AR11         5           KAHPd11      4.0

// apobdistRb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobdistRb  apobdistRa  42.4  42.4 0   1.24   Ca_d11    -6.1180971e17  NaF11       100  \
                                              NaP11       0.04         KDR11        0  \
                                              KA11      272            K211         2  \
                                              KM11       84            CaL11        2  \
                                              CaH11       4            KCd11        0  \
                                              AR11        5          KAHPd11      4.0

// apobdistRc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobdistRc  apobdistRb  42.4  42.4 0   1.24    Ca_d11 -6.1180994e17     NaF11       100  \
                                              NaP11       0.04         KDR11        0  \
                                              KA11      272            K211         2  \
                                              KM11       84            CaL11        2  \
                                              CaH11       4            KCd11        0  \
                                              AR11        5            KAHPd11      4.0

// apobdistLa  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobdistLa  apdend3  -42.4  -42.4 0   1.24      Ca_d11 -6.1180627e17     NaF11      1500  \
                                               NaP11        0.6         KDR11      1500  \
                                               KA11       272           K211         2  \
                                               KM11        84           CaL11        2  \
                                               CaH11        4           KCd11      300  \
                                               AR11         5         KAHPd11      4.0

// apobdistLb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobdistLb  apobdistLa  -42.4  -42.4 0   1.24    Ca_d11 -6.11809714e17    NaF11       100  \
                                                NaP11       0.04         KDR11        0  \
                                                KA11      272            K211         2  \
                                                KM11       84            CaL11        2  \
                                                CaH11       4            KCd11        0  \
                                                AR11        5            KAHPd11      4.0

// apobdistLc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobdistLc  apobdistLb  -42.4  -42.4 0   1.24    Ca_d11 -6.1180994e17     NaF11       100  \
                                                NaP11       0.04         KDR11        0  \
                                                KA11      272            K211         2  \
                                                KM11       84            CaL11        2  \
                                                CaH11       4            KCd11        0  \
                                                AR11        5            KAHPd11      4.0

// apobmidRa  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobmidRa  apdend2  42.4  -42.4  0   1.24      Ca_d11 -6.1180483E17     NaF11      1500  \
                                              NaP11        0.6         KDR11      1500  \
                                              KA11       272           K211         2  \
                                              KM11        84           CaL11        2  \
                                              CaH11        4           KCd11      300  \
                                              AR11         5           KAHPd11      4.0

// apobmidRb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobmidRb  apobmidRa  42.4  -42.4  0   1.24     Ca_d11 -6.118106E17      NaF11       100  \
                                               NaP11       0.04         KDR11        0  \
                                               KA11      272            K211         2  \
                                               KM11       84            CaL11        2  \
                                               CaH11       4            KCd11        0  \
                                               AR11        5            KAHPd11      4.0

// apobmidRc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobmidRc  apobmidRb  42.4  -42.4  0   1.24     Ca_d11 -6.1179686E17     NaF11       100  \
                                               NaP11       0.04         KDR11        0  \
                                               KA11      272            K211         2  \
                                               KM11       84            CaL11        2  \
                                               CaH11       4            KCd11        0  \
                                               AR11        5            KAHPd11      4.0

// apobmidLa  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobmidLa  apdend2  -42.4  42.4  0   1.24     Ca_d11 -6.1180483E17     NaF11      1500  \
                                              NaP11        0.6         KDR11      1500  \
                                              KA11       272           K211         2  \
                                              KM11        84           CaL11        2  \
                                              CaH11        4           KCd11      300  \
                                              AR11         5          KAHPd11      4.0

// apobmidLb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobmidLb  apobmidLa  -42.4  42.4  0   1.24    Ca_d11  -6.118106E17      NaF11       100  \
                                               NaP11       0.04         KDR11        0  \
                                               KA11      272            K211         2  \
                                               KM11       84            CaL11        2  \
                                               CaH11       4            KCd11        0  \
                                               AR11        5            KAHPd11      4.0

// apobmidLc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobmidLc  apobmidLb  -42.4  42.4  0   1.24    Ca_d11 -6.1179686E17      NaF11       100  \
                                               NaP11       0.04         KDR11        0  \
                                               KA11      272            K211         2  \
                                               KM11       84            CaL11        2  \
                                               CaH11       4            KCd11        0  \
                                               AR11        5            KAHPd11      4.0

// apobproxRa  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobproxRa  apdend1  42.4  42.4  0   1.24    Ca_d11 -6.1180297E17     NaF11      1500  \
                                             NaP11        0.6         KDR11      1500  \
                                             KA11       272           K211         2  \
                                             KM11        84           CaL11        2  \
                                             CaH11        4           KCd11      300  \
                                             AR11         5           KAHPd11      4.0

// apobproxRb Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobproxRb  apobproxRa  42.4  42.4  0 1.24    Ca_d11 -6.118106E17      NaF11       100  \
                                              NaP11       0.04         KDR11        0  \
                                              KA11      272            K211         2  \
                                              KM11       84            CaL11        2  \
                                              CaH11       4            KCd11        0  \
                                              AR11        5           KAHPd11      4.0

// apobproxRc Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobproxRc  apobproxRb  42.4  42.4  0 1.24    Ca_d11 -6.1181232E17     NaF11       100  \
                                              NaP11       0.04         KDR11        0  \
                                              KA11      272            K211         2  \
                                              KM11       84            CaL11        2  \
                                              CaH11       4            KCd11        0  \
                                              AR11        5            KAHPd11      4.0

// apobproxLa  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobproxLa  apdend1  -42.4  -42.4  0   1.24    Ca_d11 -6.1180297E17     NaF11      1500 \
                                               NaP11        0.6         KDR11      1500 \
                                               KA11       272           K211         2  \
                                               KM11        84           CaL11        2  \
                                               CaH11        4           KCd11      300  \
                                               AR11         5          KAHPd11      4.0

// apobproxLb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobproxLb  apobproxLa  -42.4  -42.4  0  1.24   Ca_d11 -6.118106E17      NaF11       100 \
                                                NaP11       0.04         KDR11        0  \
                                                KA11      272            K211         2  \
                                                KM11       84            CaL11        2  \
                                                CaH11       4            KCd11        0  \
                                                AR11        5          KAHPd11        4.0

// apobproxLc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
apobproxLc  apobproxLb  -42.4  -42.4  0  1.24   Ca_d11 -6.118106E17      NaF11       100 \
                                                NaP11       0.04         KDR11        0  \
                                                KA11      272            K211         2  \
                                                KM11       84            CaL11        2  \
                                                CaH11       4            KCd11        0  \
                                                AR11        5          KAHPd11      4.0

*set_compt_param     RA 2.5
*set_compt_param     CM 0.018
*set_compt_param     ELEAK -0.0666
*set_compt_param     RM 2.5


//BASAL DENDRITE COMPARTMENTS ************************************************
// basalLsupera  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalLsupera  soma  -26.8  -46.4  -27.2  1.7    Ca_d11 -4.05689382E17  NaF11        1500  \
                                                NaP11        0.6     KDR11        1500  \
                                                KA11       272       K211           2  \
                                                KM11        84       CaL11          2  \
                                                CaH11        4       KCd11        300  \
                                                AR11         5       KAHPd11        4.0

// basalLsuperb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalLsuperb  basalLsupera  -26.8  -46.4 -27.2  1.7     Ca_d11 -4.05691135E17  NaF11        100  \
                                                        NaP11        0.04    KDR11          0  \
                                                        KA11       272       K211           2  \
                                                        KM11        84       CaL11          2  \
                                                        CaH11        4       KCd11          0  \
                                                        AR11         5       KAHPd11        4.0

// basalLsuperc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalLsuperc  basalLsuperb  -26.8  -46.4 -27.2  1.7     Ca_d11 -4.05691135E17 NaF11         100  \
                                                        NaP11        0.04    KDR11          0  \
                                                        KA11       136       K211           2  \
                                                        KM11        84       CaL11          2  \
                                                        CaH11        4       KCd11          0  \
                                                        AR11         5       KAHPd11        4.0

// basalLmida  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalLmida  soma  -19.3  33.4  -46.0  1.7      Ca_d11 -4.05689382E17  NaF11        1500  \
                                                NaP11        0.6     KDR11        1500  \
                                                KA11       272       K211           2  \
                                                KM11        84       CaL11          2  \
                                                CaH11        4       KCd11        300  \
                                                AR11         5       KAHPd11        4.0

// basalLmidb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalLmidb  basalLmida  -19.3  33.4 -46.0  1.7         Ca_d11 -4.05689382E17 NaF11         100  \
                                                       NaP11        0.04    KDR11          0  \
                                                       KA11       272       K211           2  \
                                                       KM11        84       CaL11          2  \
                                                       CaH11        4       KCd11          0  \
                                                       AR11         5       KAHPd11        4.0

// basalLmidc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalLmidc  basalLmidb  -19.3  33.4 -46.0  1.7         Ca_d11    -4.05689382E17  NaF11     100  \
                                                       NaP11        0.04    KDR11          0  \
                                                       KA11       272       K211           2  \
                                                       KM11        84       CaL11          2  \
                                                       CaH11        4       KCd11          0  \
                                                       AR11         5       KAHPd11        4.0

// basalRsupera  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalRsupera  soma   26.8  46.4  -27.2  1.7    Ca_d11    -4.05689382E17  NaF11        1500  \
                                               NaP11        0.6     KDR11        1500  \
                                               KA11       272       K211           2  \
                                               KM11        84       CaL11          2  \
                                               CaH11        4       KCd11        200  \
                                               AR11         5     KAHPd11        4.0

// basalRsuperb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalRsuperb  basalRsupera   26.8  46.4 -27.2  1.7     Ca_d11 -4.05689382E17 NaF11         100  \
                                                       NaP11        0.04    KDR11          0  \
                                                       KA11       272       K211           2  \
                                                       KM11        84       CaL11          2  \
                                                       CaH11        4       KCd11          0  \
                                                       AR11         5       KAHPd11        4.0

// basalRsuperc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalRsuperc  basalRsuperb   26.8  46.4 -27.2  1.7     Ca_d11 -4.05689382E17 NaF11         100  \
                                                       NaP11        0.04    KDR11          0  \
                                                       KA11       272       K211           2  \
                                                       KM11        84       CaL11          2  \
                                                       CaH11        4       KCd11          0  \
                                                       AR11         5       KAHPd11        4.0

// basalRmida  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalRmida  soma   19.3  -33.4  -46.0  1.7      Ca_d11  -4.05689382E17   NaF11    1500  \
                                                NaP11        0.6         KDR11    1500  \
                                                KA11       272           K211       2  \
                                                KM11        84           CaL11      2  \
                                                CaH11        4           KCd11    300  \
                                                AR11         5           KAHPd11    4.0

// basalRmidb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalRmidb  basalRmida   19.3  -33.4 -46.0  1.7     Ca_d11 -4.05689382E17     NaF11     100  \
                                                    NaP11        0.04        KDR11      0  \
                                                    KA11       272           K211       2  \
                                                    KM11        84           CaL11      2  \
                                                    CaH11        4           KCd11      0  \
                                                    AR11         5           KAHPd11    4.0

// basalRmidc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basalRmidc  basalRmidb   19.3  -33.4 -46.0  1.7     Ca_d11 -4.05689382E17     NaF11     100  \
                                                    NaP11        0.04        KDR11      0  \
                                                    KA11       272           K211       2  \
                                                    KM11        84           CaL11      2  \
                                                    CaH11        4           KCd11      0  \
                                                    AR11         5           KAHPd11    4.0

// basaldeepa  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basaldeepa  soma  0  0  -60.0  1.7          Ca_d11 -4.05689382E17    NaF11    1500  \
                                            NaP11        0.6         KDR11    1500  \
                                            KA11       272           K211       2  \
                                            KM11        84           CaL11      2  \
                                            CaH11        4           KCd11    300  \
                                            AR11         5           KAHPd11    4.0

// basaldeepb  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basaldeepb  basaldeepa  0  0 -60.0  1.7             Ca_d11 -4.05689382E17     NaF11     100  \
                                                    NaP11        0.04        KDR11      0  \
                                                    KA11       272           K211       2  \
                                                    KM11        84           CaL11      2  \
                                                    CaH11        4           KCd11      0  \
                                                    AR11         5           KAHPd11    4.0

// basaldeepc  Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
basaldeepc  basaldeepb  0  0 -60.0  1.7             Ca_d11 -4.05689382E17     NaF11     100  \
                                                    NaP11        0.04        KDR11      0  \
                                                    KA11       272           K211       2  \
                                                    KM11        84           CaL11      2  \
                                                    CaH11        4           KCd11      0  \
                                                    AR11         5           KAHPd11    4.0


//              Specifying constants for axonal compartment RMCM=0.0024 (0.0009)
*set_compt_param        RM      0.10   //(0.1)
*set_compt_param        RA      1.00   //(1.00)
*set_compt_param        CM      0.009  //(0.009)(0.024)
*set_compt_param        ELEAK   -0.0666

//AXONAL COMPARTMENTS ***************************************
// axona Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
// Differs from Traub et al., in that axon is vertical
axona  soma  0  0 -25  1.8      NaF11       4500   \
                                KDR11       4500   \
                                KA11          40       K211               1

// axonb Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
// Differs from Traub et al., in that axon is vertical
axonb  axona  0  0 -50  1.8     NaF11       4500   \
                                KDR11       4500   \
                                KA11          40       K211               1

// axonLa Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
// Differs from Traub et al., in that axon is vertical
axonLa  axonb  -8.7  0 -49.2  1.8    NaF11       4500   \
                                     KDR11       4500   \
                                     KA11          40  K211               1

// axonLb Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
// Differs from Traub et al., in that axon is vertical
axonLb  axonLa  -8.7  0 -49.2  1.8   NaF11       4500   \
                                     KDR11       4500   \
                                     KA11          40  K211               1

// axonRa Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
// Differs from Traub et al., in that axon is vertical
axonRa  axonb   8.7  0 -49.2  1.8    NaF11       4500   \
                                     KDR11       4500   \
                                     KA11          40  K211               1

// axonRb Fig A6 Traub et al. J. Neurophysiol 2005;93:2194-2232
// Differs from Traub et al., in that axon is vertical
axonRb  axonRa   8.7  0 -49.2  1.8   NaF11       4500   \
                                     KDR11       4500   \
                                     KA11          40  K211               1


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