A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)

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Accession:206238
A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites. The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
References:
1 . Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. J Neural Eng 12:046016 [PubMed]
2 . Basu I, Kudela P, Anderson WS (2014) Determination of seizure propagation across microdomains using spectral measures of causality. Conf Proc IEEE Eng Med Biol Soc 2014:6349-52 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Thalamus reticular nucleus GABA cell; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron;
Channel(s): I Na,p; I Na,t; I K; I A; I M; I h; I K,Ca; I A, slow; I L high threshold; I T low threshold; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba; Amino Acids;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Epilepsy;
Implementer(s): Anderson, WS ; Kudela, Pawel ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow; Amino Acids; Gaba; Glutamate;
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BasuEtAl2015
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ModelDescription.pdf
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P6RSd_P6RSc.g
P6RSd_P6RSd.g
P6RSd_P6RSd_Gap.g
P6RSd_raninput.g
P6RSd_ST4RS.g
P6RSd_synapsedefs.g
P6RSd_TCR.g
P6RSdcell3Dpk.p
P6RSdchanpk.g
P6RSdprotodefs.g
P6RSsyncond.g
pgenesis_command
protodefs.g
protospikeB23FS.g
protospikeB5FS.g
protospikeC23FS.g
protospikeC5FS.g
protospikeI23LTS.g
protospikeI5LTS.g
protospikenRT.g
protospikeP23FRBa.g
protospikeP23RSa.g
protospikeP23RSb.g
protospikeP23RSc.g
protospikeP23RSd.g
protospikeP5IBa.g
protospikeP5IBb.g
protospikeP5IBc.g
protospikeP5IBd.g
protospikeP5RSa.g
protospikeP6RSa.g
protospikeP6RSb.g
protospikeP6RSc.g
protospikeP6RSd.g
protospikeST4RS.g
protospikeTCR.g
randominputdefs.g
spikedefs.g
ST4RS.g
ST4RS_B23FS.g
ST4RS_B5FS.g
ST4RS_C23FS.g
ST4RS_C5FS.g
ST4RS_I23LTS.g
ST4RS_I5LTS.g
ST4RS_P23FRBa.g
ST4RS_P23RSa.g
ST4RS_P23RSb.g
ST4RS_P23RSc.g
ST4RS_P23RSd.g
ST4RS_P5IBa.g
ST4RS_P5IBb.g
ST4RS_P5IBc.g
ST4RS_P5IBd.g
ST4RS_P5RSa.g
ST4RS_P6RSa.g
ST4RS_P6RSb.g
ST4RS_P6RSc.g
ST4RS_P6RSd.g
ST4RS_raninput.g
ST4RS_ST4RS.g
ST4RS_ST4RS_Gap.g
ST4RS_synapsedefs.g
ST4RScell3Dpk.p
ST4RSchanpk.g
ST4RSprotodefs.g
ST4RSsyncond.g
synapticdelays.g *
synapticprobsTraub.g
synchansB23FS.g *
synchansB5FS.g *
synchansC23FS.g *
synchansC5FS.g *
synchansI23LTS.g *
synchansI5LTS.g *
synchansnRT.g *
synchansP23FRBa.g *
synchansP23RSa.g *
synchansP23RSb.g *
synchansP23RSc.g *
synchansP23RSd.g *
synchansP5IBa.g *
synchansP5IBb.g *
synchansP5IBc.g *
synchansP5IBd.g *
synchansP5RSa.g *
synchansP6RSa.g *
synchansP6RSb.g *
synchansP6RSc.g *
synchansP6RSd.g *
synchansSPIKEs.g *
synchansSPIKEs_base.g
synchansST4RS.g
synchansTCR.g *
syncond.g
syncond2.g
TCR.g
TCR_B23FS.g
TCR_B5FS.g
TCR_C23FS.g
TCR_C5FS.g
TCR_nRT.g
TCR_P23FRBa.g
TCR_P23RSa.g
TCR_P23RSb.g
TCR_P23RSc.g
TCR_P23RSd.g
TCR_P5IBa.g
TCR_P5IBb.g
TCR_P5IBc.g
TCR_P5IBd.g
TCR_P5RSa.g
TCR_P6RSa.g
TCR_P6RSb.g
TCR_P6RSc.g
TCR_P6RSd.g
TCR_raninput.g
TCR_ST4RS.g
TCR_synapsedefs.g
TCRcellpk.p
TCRchanpk.g
TCRprotodefs.g
TCRsyncond.g
                            
// ST4RScell3D.p cell.p - Cell parameter file used in TraubFS_B

//	Format of file :
// x,y,z,dia are in microns, all other units are SI (Meter Kilogram Sec Amp)
// In polar mode 'r' is in microns, theta and phi in degrees 
// Control line options start with a '*'
// The format for each compartment parameter line is :
//name	parent	r	theta	phi	d	ch	dens ...
//in polar mode, and in cartesian mode :
//name	parent	x	y	z	d	ch	dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment
// For spike elements, "dens" is the spike threshold
//		Coordinate mode
*relative
*cartesian
*asymmetric

*set_global              EREST_ACT      -0.07

//		Specifying constants
   *set_compt_param	RM	5  //0.33333 (2.50)
   *set_compt_param	RA	2.50  //0.3 (2.00)
   *set_compt_param	CM	0.009  //0.01 (0.01)
//   *set_compt_param     EREST_ACT	-0.065  //
   *set_compt_param     ELEAK           -0.0666   // -0.0710


//SOMA *************************************************************   
// For the soma, use the leakage potential (-0.07 + 0.0106) for Em
//*set_compt_param     ELEAK	-0.0594
// Actually, after Cunningham et al. PNAS 2004;101:7152-7157, will maintain
// leakage potential at ELEAK   -0.07
soma  none  0   0  20 15.0  Ca_s17  -5.5173713E16  NaF17  1500 \
                            NaP17   1.5   KDR17   1000 \
                            KA17    300   K217    1.0  \
                            CaH17   5.0   KCs17   100  \
                            KM17    37.5  KAHPs17 2.0  \
                            AR17    2.5	  CaL17	  1

//*set_compt_param        ELEAK   -0.075
*set_compt_param	RM	2.50  //0.33333 (2.50)
*set_compt_param	RA	2.50  //0.3 (2.00)
*set_compt_param	CM	0.018  //0.01 (0.01)

//PROXIMAL DENDRITE COMPARTMENTS ***************************************

// proxdendN   Cunningham et al., PNAS  2004;101:7152-7157
proxdendN  soma  0  0  40 2.12  Ca_d17 -1.95190046E17    NaF17       1500   \
                                NaP17          1.5       KDR17       1500   \
                                KA17         600         K217           2   \
                                CaH17         10         KCd17        200   \
                                KM17          75         KAHPd17        2.0 \
                                AR17           5         CaL17          2

// proxdendE   Cunningham et al., PNAS  2004;101:7152-7157
proxdendE  soma  40  0  0 2.12  Ca_d17  -1.95190046E17   NaF17       1500   \
                                NaP17          1.5       KDR17       1500   \
                                KA17          600        K217           2   \
                                CaH17         10         KCd17        200   \
                                KM17          75         KAHPd17        2.0 \
                                AR17           5         CaL17          2

// proxdendS   Cunningham et al., PNAS  2004;101:7152-7157
proxdendS  soma  0  0  -40 2.12 Ca_d17  -1.95190046E17   NaF17       1500   \
                                NaP17          1.5       KDR17       1500   \
                                KA17          600        K217          2   \
                                CaH17          10        KCd17       200   \
                                KM17           75        KAHPd17       2.0 \
                                AR17           5         CaL17         2 

// proxdendW   Cunningham et al., PNAS  2004;101:7152-7157
proxdendW  soma  -40 0  0 2.12  Ca_d17  -1.95190046E17   NaF17       1500   \
                                NaP17        1.5         KDR17       1500   \
                                KA17         600         K217           2   \
                                CaH17         10         KCd17        200   \
                                KM17          75         KAHPd17        2.0 \
                                AR17           6         CaL17         2


*set_compt_param	RM	2.5  //0.33333 (2.50)
*set_compt_param	RA	2.5  //0.3 (2.00)
*set_compt_param	CM	0.018  //0.01 (0.01)
//*set_compt_param     ELEAK	-0.075


//North DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendNlonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlonga  proxdendN  -6.84  11.8 37.6 1.34  Ca_d17 -3.10352894E17    NaF17     1500   \
                                                  NaP17         1.5        KDR17     1500   \
                                                  KA17          40         K217        2   \
                                                  CaH17         10         KCd17     200   \
                                                  KM17          75         KAHPd17     2.0 \
                                                  AR17           5         CaL17        2 

// distdendNlongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongb  distdendNlonga  -6.84 11.8 37.6 1.34    Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17     200   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendNlongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongc  distdendNlongb  -6.84 11.8 37.6 0.84    Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendNlongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongd  distdendNlongc  -6.84 11.8 37.6 0.84    Ca_d17 -4.93830564E17    NaF17      100  \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendNlonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlonge  distdendNlongd  -6.84 11.8 37.6 0.84    Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendNlongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongf  distdendNlonge  -6.84 11.8 37.6 0.84    Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendNlongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendNlongg  distdendNlongf  -6.84 11.8 37.6 0.84    Ca_d17 -4.93830426E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendNmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendNmida  proxdendN  6.84  -11.8 37.6  1.34   Ca_d17 -3.10352894E17    NaF17     1500   \
                                                   NaP17         1.5        KDR17     1500   \
                                                   KA17          40         K217        2    \
                                                   CaH17         10         KCd17     200   \
                                                   KM17          75         KAHPd17     2.0 \
                                                   AR17           5         CaL17       2

// distdendNmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendNmidb  distdendNmida  6.84 -11.8 37.6  1.34     Ca_d17 -3.1035389E17     NaF17      100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       200 \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendNmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendNmidc  distdendNmidb  6.84 -11.8 37.6  0.84      Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17         0.1        KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2      

// distdendNshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendNshorta  distdendNlonga   6.84  -11.8 37.6  0.84  Ca_d17 -4.93830564E17    NaF17      100  \
                                                          NaP17         0.1        KDR17       0   \
                                                          KA17          40         K217        2   \
                                                          CaH17         10         KCd17       200 \
                                                          KM17          75         KAHPd17     2.0 \
                                                          AR17           5         CaL17       2

// distdendNshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendNshortb  distdendNshorta 6.84 -11.8 37.6  0.84   Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17          0.1       KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2

//East DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendElonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendElonga  proxdendE  32.5  18.8 13.68 1.34  Ca_d17 -3.10352894E17    NaF17     1500   \
                                                  NaP17         1.5        KDR17     1500   \
                                                  KA17          40         K217        2   \
                                                  CaH17         10         KCd17     200   \
                                                  KM17          75         KAHPd17     2.0 \
                                                  AR17           5         CaL17        2

// distdendElongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongb  distdendElonga  32.5 18.8 13.68 1.34   Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17     200   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendElongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongc  distdendElongb  32.5 18.8 13.68 0.84   Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendElongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongd  distdendElongc  32.5 18.8 13.68 0.84    Ca_d17 -4.93830564E17    NaF17      100  \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendElonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendElonge  distdendElongd  32.5 18.8 13.68 0.84   Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendElongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongf  distdendElonge  32.5 18.8 13.68 0.84   Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendElongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendElongg  distdendElongf  32.5 18.8 13.68 0.84   Ca_d17 -4.93830426E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendEmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendEmida  proxdendE  32.5 18.8 -13.68 1.34    Ca_d17 -3.10352894E17    NaF17     1500   \
                                                   NaP17         1.5        KDR17     1500   \
                                                   KA17          40         K217        2   \
                                                   CaH17         10         KCd17     200   \
                                                   KM17          75         KAHPd17     2.0 \
                                                   AR17           5         CaL17       2

// distdendEmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendEmidb  distdendEmida 32.5 18.8 -13.68  1.34    Ca_d17 -3.1035389E17     NaF17      100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       200 \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendEmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendEmidc  distdendEmidb  32.5 18.8 -13.68  0.84    Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17         0.1        KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2

// distdendEshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendEshorta  distdendElonga   32.5  18.8  -13.68 0.84 Ca_d17 -4.93830564E17    NaF17      100  \
                                                          NaP17         0.1        KDR17       0   \
                                                          KA17          40         K217        2   \
                                                          CaH17         10         KCd17       200 \
                                                          KM17          75         KAHPd17     2.0 \
                                                          AR17           5         CaL17       2

// distdendEshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendEshortb  distdendEshorta 32.5 18.8 -13.68 0.84 Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17          0.1       KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2

//South DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendSlonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlonga  proxdendS  6.84  -11.8 -37.6 1.34  Ca_d17 -3.10352894E17    NaF17     1500   \
                                                  NaP17         1.5        KDR17     1500   \
                                                  KA17          40         K217        2   \
                                                  CaH17         10         KCd17     200   \
                                                  KM17          75         KAHPd17     2.0 \
                                                  AR17           5         CaL17        2

// distdendSlongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongb  distdendSlonga  6.84 -11.8 -37.6 1.34    Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17     200   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendSlongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongc  distdendSlongb  6.84 -11.8 -37.6 0.84    Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendSlongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongd  distdendSlongc  6.84 -11.8 -37.6 0.84    Ca_d17 -4.93830564E17    NaF17      100  \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendSlonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlonge  distdendSlongd  6.84 -11.8 -37.6 0.84    Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendSlongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongf  distdendSlonge  6.84 -11.8 -37.6 0.84    Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendSlongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendSlongg  distdendSlongf  6.84 -11.8 -37.6 0.84    Ca_d17 -4.93830426E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendSmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendSmida  proxdendS  -6.84  11.8 -37.6 1.34   Ca_d17 -3.10352894E17    NaF17     1500   \
                                                   NaP17         1.5        KDR17     1500   \
                                                   KA17          40         K217        2   \
                                                   CaH17         10         KCd17     200   \
                                                   KM17          75         KAHPd17     2.0 \
                                                   AR17           5         CaL17       2

// distdendSmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendSmidb  distdendSmida  -6.84 11.8 -37.6 2.34    Ca_d17 -3.1035389E17     NaF17      100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       200 \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendSmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendSmidc  distdendSmidb  -6.84 11.8 -37.6  0.84     Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17         0.1        KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2

// distdendSshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendSshorta  distdendSlonga   -6.84  11.8 -37.6 0.84  Ca_d17 -4.93830564E17    NaF17      100  \
                                                          NaP17         0.1        KDR17       0   \
                                                          KA17          40         K217        2   \
                                                          CaH17         10         KCd17       200 \
                                                          KM17          75         KAHPd17     2.0 \
                                                          AR17           5         CaL17       2

// distdendSshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendSshortb  distdendSshorta -6.84 11.8 -37.6 0.84  Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17          0.1       KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2

//West DISTAL DENDRITE COMPARTMENTS ***************************************
// distdendWlonga   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlonga  proxdendW -32.5 -18.8 13.68 1.34   Ca_d17 -3.10352894E17    NaF17     1500   \
                                                  NaP17         1.5        KDR17     1500   \
                                                  KA17          40         K217        2   \
                                                  CaH17         10         KCd17     200   \
                                                  KM17          75         KAHPd17     2.0 \
                                                  AR17           5         CaL17       2

// distdendWlongb   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongb  distdendWlonga -32.5 -18.8 13.68 1.34   Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17     200   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendWlongc   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongc  distdendWlongb -32.5 -18.8 13.68 0.84   Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendWlongd   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongd  distdendWlongc -32.5 -18.8 13.68 0.84    Ca_d17 -4.93830564E17    NaF17      100  \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendWlonge   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlonge  distdendWlongd -32.5 -18.8 13.68 0.84   Ca_d17 -4.93830564E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendWlongf   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongf  distdendWlonge -32.5 -18.8 13.68 0.84   Ca_d17 -4.93830564E17    NaF17     100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendWlongg   Cunningham et al., PNAS  2004;101:7152-7157
distdendWlongg  distdendWlongf -32.5 -18.8 13.68 0.84   Ca_d17 -4.93830426E17    NaF17      100   \
                                                        NaP17          0.1       KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         60         KCd17       0   \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendWmida   Cunningham et al., PNAS  2004;101:7152-7157
distdendWmida  proxdendW  -32.5 -18.8 -13.68 1.34  Ca_d17 -3.10352894E17    NaF17     1500   \
                                                   NaP17         1.5        KDR17     1500   \
                                                   KA17          40         K217        2   \
                                                   CaH17         10         KCd17     200   \
                                                   KM17          75         KAHPd17     2.0 \
                                                   AR17           5         CaL17       2

// distdendWmidb   Cunningham et al., PNAS  2004;101:7152-7157
distdendWmidb  distdendWmida -32.5 -18.8 -13.68  1.34   Ca_d17 -3.1035389E17     NaF17      100   \
                                                        NaP17         0.1        KDR17       0   \
                                                        KA17          40         K217        2   \
                                                        CaH17         10         KCd17       200 \
                                                        KM17          75         KAHPd17     2.0 \
                                                        AR17           5         CaL17       2

// distdendWmidc   Cunningham et al., PNAS  2004;101:7152-7157
distdendWmidc  distdendWmidb  -32.5 -18.8 -13.68  0.84   Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17         0.1        KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2

// distdendWshorta   Cunningham et al., PNAS  2004;101:7152-7157
distdendWshorta  distdendWlonga   -32.5  -18.8 -13.68 0.84 Ca_d17 -4.93830564E17    NaF17      100  \
                                                          NaP17         0.1        KDR17       0   \
                                                          KA17          40         K217        2   \
                                                          CaH17         10         KCd17       200 \
                                                          KM17          75         KAHPd17     2.0 \
                                                          AR17           5         CaL17       2

// distdendWshortb   Cunningham et al., PNAS  2004;101:7152-7157
distdendWshortb  distdendWshorta -32.5 -18.8 -13.68 0.84  Ca_d17 -4.93817851E17    NaF17      100  \
                                                         NaP17          0.1       KDR17       0   \
                                                         KA17          40         K217        2   \
                                                         CaH17         10         KCd17       0   \
                                                         KM17          75         KAHPd17     2.0 \
                                                         AR17           5         CaL17       2

//		Specifying constants for axonal compartment

   *set_compt_param	RM	0.1   // (0.1)
   *set_compt_param	RA	1.0   // (1.0)
   *set_compt_param	CM	0.009  // (0.01) RC = 0.001
   *set_compt_param     ELEAK	-0.0666
  
// axona Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axona  soma  0  0 -25  1.4      NaF17       4000   \
                                KDR17       4000   \
                                KA17          20   K217          1

// axonb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonb  axona  0  0 -50  1.2     NaF17       4000   \
                                KDR17       4000   \
                                KA17          20   K217          1

// axonLa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLa  axonb  -8.7  0 -49.2  1    NaF17       4000   \
                                     KDR17     4000   \
                                     KA17       20   K217     1

// axonLb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonLb  axonLa  -8.7  0 -49.2  1.0   NaF17       4000   \
                                     KDR17       4000   \
                                     KA17         20   K217     1    

// axonRa Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRa  axonb   8.7  0 -49.2  1.0    NaF17       4000   \
                                     KDR17       4000   \
                                     KA17         20   K217     1

// axonRb Fig 1. Traub et al., J Neurophysiol 2003;89:909-921
// Differs from Traub et al., in that axon is vertical
axonRb  axonRa   8.7  0 -49.2  1.0   NaF17       4000   \
                                     KDR17       4000   \
                                     KA17        20   K217     1

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