A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)

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Accession:206238
A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites. The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
References:
1 . Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. J Neural Eng 12:046016 [PubMed]
2 . Basu I, Kudela P, Anderson WS (2014) Determination of seizure propagation across microdomains using spectral measures of causality. Conf Proc IEEE Eng Med Biol Soc 2014:6349-52 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Thalamus reticular nucleus GABA cell; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron;
Channel(s): I Na,p; I Na,t; I K; I A; I M; I h; I K,Ca; I A, slow; I L high threshold; I T low threshold; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba; Amino Acids;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Epilepsy;
Implementer(s): Anderson, WS ; Kudela, Pawel ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow; Amino Acids; Gaba; Glutamate;
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BasuEtAl2015
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ModelDescription.pdf
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P6RSd_P6RSc.g
P6RSd_P6RSd.g
P6RSd_P6RSd_Gap.g
P6RSd_raninput.g
P6RSd_ST4RS.g
P6RSd_synapsedefs.g
P6RSd_TCR.g
P6RSdcell3Dpk.p
P6RSdchanpk.g
P6RSdprotodefs.g
P6RSsyncond.g
pgenesis_command
protodefs.g
protospikeB23FS.g
protospikeB5FS.g
protospikeC23FS.g
protospikeC5FS.g
protospikeI23LTS.g
protospikeI5LTS.g
protospikenRT.g
protospikeP23FRBa.g
protospikeP23RSa.g
protospikeP23RSb.g
protospikeP23RSc.g
protospikeP23RSd.g
protospikeP5IBa.g
protospikeP5IBb.g
protospikeP5IBc.g
protospikeP5IBd.g
protospikeP5RSa.g
protospikeP6RSa.g
protospikeP6RSb.g
protospikeP6RSc.g
protospikeP6RSd.g
protospikeST4RS.g
protospikeTCR.g
randominputdefs.g
spikedefs.g
ST4RS.g
ST4RS_B23FS.g
ST4RS_B5FS.g
ST4RS_C23FS.g
ST4RS_C5FS.g
ST4RS_I23LTS.g
ST4RS_I5LTS.g
ST4RS_P23FRBa.g
ST4RS_P23RSa.g
ST4RS_P23RSb.g
ST4RS_P23RSc.g
ST4RS_P23RSd.g
ST4RS_P5IBa.g
ST4RS_P5IBb.g
ST4RS_P5IBc.g
ST4RS_P5IBd.g
ST4RS_P5RSa.g
ST4RS_P6RSa.g
ST4RS_P6RSb.g
ST4RS_P6RSc.g
ST4RS_P6RSd.g
ST4RS_raninput.g
ST4RS_ST4RS.g
ST4RS_ST4RS_Gap.g
ST4RS_synapsedefs.g
ST4RScell3Dpk.p
ST4RSchanpk.g
ST4RSprotodefs.g
ST4RSsyncond.g
synapticdelays.g *
synapticprobsTraub.g
synchansB23FS.g *
synchansB5FS.g *
synchansC23FS.g *
synchansC5FS.g *
synchansI23LTS.g *
synchansI5LTS.g *
synchansnRT.g *
synchansP23FRBa.g *
synchansP23RSa.g *
synchansP23RSb.g *
synchansP23RSc.g *
synchansP23RSd.g *
synchansP5IBa.g *
synchansP5IBb.g *
synchansP5IBc.g *
synchansP5IBd.g *
synchansP5RSa.g *
synchansP6RSa.g *
synchansP6RSb.g *
synchansP6RSc.g *
synchansP6RSd.g *
synchansSPIKEs.g *
synchansSPIKEs_base.g
synchansST4RS.g
synchansTCR.g *
syncond.g
syncond2.g
TCR.g
TCR_B23FS.g
TCR_B5FS.g
TCR_C23FS.g
TCR_C5FS.g
TCR_nRT.g
TCR_P23FRBa.g
TCR_P23RSa.g
TCR_P23RSb.g
TCR_P23RSc.g
TCR_P23RSd.g
TCR_P5IBa.g
TCR_P5IBb.g
TCR_P5IBc.g
TCR_P5IBd.g
TCR_P5RSa.g
TCR_P6RSa.g
TCR_P6RSb.g
TCR_P6RSc.g
TCR_P6RSd.g
TCR_raninput.g
TCR_ST4RS.g
TCR_synapsedefs.g
TCRcellpk.p
TCRchanpk.g
TCRprotodefs.g
TCRsyncond.g
                            
// genesis
// synapticprobs.g

//P23RSa spatial connection scales

float P23RSdecayrate, P23RSmaxwgt, P23RSminwgt

P23RSdecayrate = 10000 // 1/(100e-6) m^-1
P23RSmaxwgt = 1.0
P23RSminwgt = 0.0

float P23RSa_P23RSa_prob = 0.104
float P23RSa_P23RSb_prob = 0.104 
float P23RSa_P23RSc_prob = 0.104 
float P23RSa_P23RSd_prob = 0.104 
float P23RSa_B23FS_prob = 0.186
float P23RSa_P5IBa_prob = 0.124
float P23RSa_P5IBb_prob = 0.124
float P23RSa_P5IBc_prob = 0.124
float P23RSa_P5IBd_prob = 0.124
float P23RSa_B5FS_prob = 0.062
float P23RSa_P6RSa_prob = 0.006  // 0.006
float P23RSa_P6RSb_prob = 0.006  // 0.006
float P23RSa_P6RSc_prob = 0.006  // 0.006
float P23RSa_P6RSd_prob = 0.006  // 0.006
float P23RSa_C23FS_prob = 0.186
float P23RSa_C5FS_prob = 0.062
float P23RSa_ST4RS_prob = 0.006
float P23RSa_I23LTS_prob = 0.186
float P23RSa_I5LTS_prob = 0.062
float P23RSa_P23FRBa_prob = 0.104 
float P23RSa_P5RSa_prob = 0.124

//P23RSb spatial connection scales

float P23RSdecayrate, P23RSmaxwgt, P23RSminwgt

P23RSdecayrate = 10000 // 1/(100e-6) m^-1
P23RSmaxwgt = 1.0
P23RSminwgt = 0.0

float P23RSb_P23RSa_prob = 0.104
float P23RSb_P23RSb_prob = 0.104 
float P23RSb_P23RSc_prob = 0.104 
float P23RSb_P23RSd_prob = 0.104 
float P23RSb_B23FS_prob = 0.186
float P23RSb_P5IBa_prob = 0.124
float P23RSb_P5IBb_prob = 0.124
float P23RSb_P5IBc_prob = 0.124
float P23RSb_P5IBd_prob = 0.124
float P23RSb_B5FS_prob = 0.062
float P23RSb_P6RSa_prob = 0.006  // 0.006
float P23RSb_P6RSb_prob = 0.006  // 0.006
float P23RSb_P6RSc_prob = 0.006  // 0.006
float P23RSb_P6RSd_prob = 0.006  // 0.006
float P23RSb_C23FS_prob = 0.186
float P23RSb_C5FS_prob = 0.062
float P23RSb_ST4RS_prob = 0.006
float P23RSb_I23LTS_prob = 0.186
float P23RSb_I5LTS_prob = 0.062
float P23RSb_P23FRBa_prob = 0.104 
float P23RSb_P5RSa_prob = 0.124

//P23RSc spatial connection scales

float P23RSdecayrate, P23RSmaxwgt, P23RSminwgt

P23RSdecayrate = 10000 // 1/(100e-6) m^-1
P23RSmaxwgt = 1.0
P23RSminwgt = 0.0

float P23RSc_P23RSa_prob = 0.104
float P23RSc_P23RSb_prob = 0.104 
float P23RSc_P23RSc_prob = 0.104 
float P23RSc_P23RSd_prob = 0.104 
float P23RSc_B23FS_prob = 0.186
float P23RSc_P5IBa_prob = 0.124
float P23RSc_P5IBb_prob = 0.124
float P23RSc_P5IBc_prob = 0.124
float P23RSc_P5IBd_prob = 0.124
float P23RSc_B5FS_prob = 0.062
float P23RSc_P6RSa_prob = 0.006  // 0.006
float P23RSc_P6RSb_prob = 0.006  // 0.006 
float P23RSc_P6RSc_prob = 0.006  // 0.006
float P23RSc_P6RSd_prob = 0.006  // 0.006
float P23RSc_C23FS_prob = 0.186
float P23RSc_C5FS_prob = 0.062
float P23RSc_ST4RS_prob = 0.006
float P23RSc_I23LTS_prob = 0.186
float P23RSc_I5LTS_prob = 0.062
float P23RSc_P23FRBa_prob = 0.104 
float P23RSc_P5RSa_prob = 0.124

//P23RSd spatial connection scales

float P23RSdecayrate, P23RSmaxwgt, P23RSminwgt

P23RSdecayrate = 10000 // 1/(100e-6) m^-1
P23RSmaxwgt = 1.0
P23RSminwgt = 0.0

float P23RSd_P23RSa_prob = 0.104
float P23RSd_P23RSb_prob = 0.104 
float P23RSd_P23RSc_prob = 0.104 
float P23RSd_P23RSd_prob = 0.104 
float P23RSd_B23FS_prob = 0.186
float P23RSd_P5IBa_prob = 0.124
float P23RSd_P5IBb_prob = 0.124
float P23RSd_P5IBc_prob = 0.124
float P23RSd_P5IBd_prob = 0.124
float P23RSd_B5FS_prob = 0.062
float P23RSd_P6RSa_prob = 0.006  // 0.006
float P23RSd_P6RSb_prob = 0.006  // 0.006
float P23RSd_P6RSc_prob = 0.006  // 0.006
float P23RSd_P6RSd_prob = 0.006  // 0.006
float P23RSd_C23FS_prob = 0.186
float P23RSd_C5FS_prob = 0.062
float P23RSd_ST4RS_prob = 0.006
float P23RSd_I23LTS_prob = 0.186
float P23RSd_I5LTS_prob = 0.062
float P23RSd_P23FRBa_prob = 0.104 
float P23RSd_P5RSa_prob = 0.124

//B23FS spatial connection scales

float B23FSdecayrate, B23FSmaxwgt, B23FSminwgt

B23FSdecayrate = 10000 // 1/(100e-6) m^-1
B23FSmaxwgt = 1.0
B23FSminwgt = 0.0

float B23FS_P23RSa_prob = 0.333
float B23FS_P23RSb_prob = 0.333
float B23FS_P23RSc_prob = 0.333
float B23FS_P23RSd_prob = 0.333
float B23FS_B23FS_prob = 0.339
float B23FS_C23FS_prob = 0.333
float B23FS_ST4RS_prob = 0.333
float B23FS_I23LTS_prob = 0.333
float B23FS_P23FRBa_prob = 0.333

//P5IBa spatial connection scales

float P5IBdecayrate, P5IBmaxwgt, P5IBminwgt

P5IBdecayrate = 10000 // 1/(100e-6) m^-1
P5IBmaxwgt = 1.0
P5IBminwgt = 0.0

float P5IBa_P23RSa_prob = 0.004
float P5IBa_P23RSb_prob = 0.004
float P5IBa_P23RSc_prob = 0.004
float P5IBa_P23RSd_prob = 0.004
float P5IBa_B23FS_prob = 0.041
float P5IBa_P5IBa_prob = 0.103
float P5IBa_P5IBb_prob = 0.103
float P5IBa_P5IBc_prob = 0.103
float P5IBa_P5IBd_prob = 0.103
float P5IBa_B5FS_prob = 0.041
float P5IBa_P6RSa_prob = 0.041  // 0.041
float P5IBa_P6RSb_prob = 0.041  // 0.041
float P5IBa_P6RSc_prob = 0.041  // 0.041
float P5IBa_P6RSd_prob = 0.041  // 0.041
float P5IBa_C23FS_prob = 0.041
float P5IBa_C5FS_prob = 0.041
float P5IBa_ST4RS_prob = 0.041
float P5IBa_I23LTS_prob = 0.041
float P5IBa_I5LTS_prob = 0.041
float P5IBa_P23FRBa_prob = 0.004
float P5IBa_P5RSa_prob = 0.041

//P5IBb spatial connection scales

float P5IBdecayrate, P5IBmaxwgt, P5IBminwgt

P5IBdecayrate = 10000 // 1/(100e-6) m^-1
P5IBmaxwgt = 1.0
P5IBminwgt = 0.0

float P5IBb_P23RSa_prob = 0.004
float P5IBb_P23RSb_prob = 0.004
float P5IBb_P23RSc_prob = 0.004
float P5IBb_P23RSd_prob = 0.004
float P5IBb_B23FS_prob = 0.041
float P5IBb_P5IBa_prob = 0.103
float P5IBb_P5IBb_prob = 0.103
float P5IBb_P5IBc_prob = 0.103
float P5IBb_P5IBd_prob = 0.103
float P5IBb_B5FS_prob = 0.041
float P5IBb_P6RSa_prob = 0.041  // 0.041
float P5IBb_P6RSb_prob = 0.041  // 0.041
float P5IBb_P6RSc_prob = 0.041  // 0.041
float P5IBb_P6RSd_prob = 0.041  // 0.041
float P5IBb_C23FS_prob = 0.041
float P5IBb_C5FS_prob = 0.041
float P5IBb_ST4RS_prob = 0.041
float P5IBb_I23LTS_prob = 0.041
float P5IBb_I5LTS_prob = 0.041
float P5IBb_P23FRBa_prob = 0.004
float P5IBb_P5RSa_prob = 0.041

//P5IBc spatial connection scales

float P5IBdecayrate, P5IBmaxwgt, P5IBminwgt

P5IBdecayrate = 10000 // 1/(100e-6) m^-1
P5IBmaxwgt = 1.0
P5IBminwgt = 0.0

float P5IBc_P23RSa_prob = 0.004
float P5IBc_P23RSb_prob = 0.004
float P5IBc_P23RSc_prob = 0.004
float P5IBc_P23RSd_prob = 0.004
float P5IBc_B23FS_prob = 0.041
float P5IBc_P5IBa_prob = 0.103
float P5IBc_P5IBb_prob = 0.103
float P5IBc_P5IBc_prob = 0.103
float P5IBc_P5IBd_prob = 0.103
float P5IBc_B5FS_prob = 0.041
float P5IBc_P6RSa_prob = 0.041  // 0.041
float P5IBc_P6RSb_prob = 0.041  // 0.041
float P5IBc_P6RSc_prob = 0.041  // 0.041
float P5IBc_P6RSd_prob = 0.041  // 0.041
float P5IBc_C23FS_prob = 0.041
float P5IBc_C5FS_prob = 0.041
float P5IBc_ST4RS_prob = 0.041
float P5IBc_I23LTS_prob = 0.041
float P5IBc_I5LTS_prob = 0.041
float P5IBc_P23FRBa_prob = 0.004
float P5IBc_P5RSa_prob = 0.041

//P5IBd spatial connection scales

float P5IBdecayrate, P5IBmaxwgt, P5IBminwgt

P5IBdecayrate = 10000 // 1/(100e-6) m^-1
P5IBmaxwgt = 1.0
P5IBminwgt = 0.0

float P5IBd_P23RSa_prob = 0.004
float P5IBd_P23RSb_prob = 0.004
float P5IBd_P23RSc_prob = 0.004
float P5IBd_P23RSd_prob = 0.004
float P5IBd_B23FS_prob = 0.041
float P5IBd_P5IBa_prob = 0.103
float P5IBd_P5IBb_prob = 0.103
float P5IBd_P5IBc_prob = 0.103
float P5IBd_P5IBd_prob = 0.103
float P5IBd_B5FS_prob = 0.041
float P5IBd_P6RSa_prob = 0.041  // 0.041
float P5IBd_P6RSb_prob = 0.041  // 0.041
float P5IBd_P6RSc_prob = 0.041  // 0.041
float P5IBd_P6RSd_prob = 0.041  // 0.041
float P5IBd_C23FS_prob = 0.041
float P5IBd_C5FS_prob = 0.041
float P5IBd_ST4RS_prob = 0.041
float P5IBd_I23LTS_prob = 0.041
float P5IBd_I5LTS_prob = 0.041
float P5IBd_P23FRBa_prob = 0.004
float P5IBd_P5RSa_prob = 0.041

//B5FS spatial connection scales

float B5FSdecayrate, B5FSmaxwgt, B5FSminwgt

B5FSdecayrate = 10000 // 1/(100e-6) m^-1
B5FSmaxwgt = 1.0
B5FSminwgt = 0.0

float B5FS_P5IBa_prob = 0.333
float B5FS_P5IBb_prob = 0.333
float B5FS_P5IBc_prob = 0.333
float B5FS_P5IBd_prob = 0.333
float B5FS_B5FS_prob = 0.339
float B5FS_P6RSa_prob = 0.333
float B5FS_P6RSb_prob = 0.333
float B5FS_P6RSc_prob = 0.333
float B5FS_P6RSd_prob = 0.333
float B5FS_C5FS_prob = 0.333 
float B5FS_ST4RS_prob = 0.333
float B5FS_I5LTS_prob = 0.333
float B5FS_P5RSa_prob = 0.333

//P6RSa spatial connection scales

float P6RSdecayrate, P6RSmaxwgt, P6RSminwgt

P6RSdecayrate = 10000 // 1/(100e-6) m^-1
P6RSmaxwgt = 1.0
P6RSminwgt = 0.0

float P6RSa_P23RSa_prob = 0.041
float P6RSa_P23RSb_prob = 0.041 
float P6RSa_P23RSc_prob = 0.041
float P6RSa_P23RSd_prob = 0.041
float P6RSa_B23FS_prob = 0.041
float P6RSa_P5IBa_prob = 0.041
float P6RSa_P5IBb_prob = 0.041
float P6RSa_P5IBc_prob = 0.041
float P6RSa_P5IBd_prob = 0.041
float P6RSa_B5FS_prob = 0.041
float P6RSa_P6RSa_prob = 0.083
float P6RSa_P6RSb_prob = 0.083
float P6RSa_P6RSc_prob = 0.083
float P6RSa_P6RSd_prob = 0.083
float P6RSa_C23FS_prob = 0.041
float P6RSa_C5FS_prob = 0.041
float P6RSa_ST4RS_prob = 0.041
float P6RSa_I23LTS_prob = 0.041
float P6RSa_I5LTS_prob = 0.041
float P6RSa_TCR_prob = 0.083
float P6RSa_nRT_prob = 0.083
float P6RSa_P23FRBa_prob = 0.041
float P6RSa_P5RSa_prob = 0.041

//P6RSb spatial connection scales

float P6RSdecayrate, P6RSmaxwgt, P6RSminwgt

P6RSdecayrate = 10000 // 1/(100e-6) m^-1
P6RSmaxwgt = 1.0
P6RSminwgt = 0.0

float P6RSb_P23RSa_prob = 0.041
float P6RSb_P23RSb_prob = 0.041 
float P6RSb_P23RSc_prob = 0.041
float P6RSb_P23RSd_prob = 0.041
float P6RSb_B23FS_prob = 0.041
float P6RSb_P5IBa_prob = 0.041
float P6RSb_P5IBb_prob = 0.041
float P6RSb_P5IBc_prob = 0.041
float P6RSb_P5IBd_prob = 0.041
float P6RSb_B5FS_prob = 0.041
float P6RSb_P6RSa_prob = 0.083
float P6RSb_P6RSb_prob = 0.083
float P6RSb_P6RSc_prob = 0.083
float P6RSb_P6RSd_prob = 0.083
float P6RSb_C23FS_prob = 0.041
float P6RSb_C5FS_prob = 0.041
float P6RSb_ST4RS_prob = 0.041
float P6RSb_I23LTS_prob = 0.041
float P6RSb_I5LTS_prob = 0.041
float P6RSb_TCR_prob = 0.083
float P6RSb_nRT_prob = 0.083
float P6RSb_P23FRBa_prob = 0.041
float P6RSb_P5RSa_prob = 0.041

//P6RSc spatial connection scales

float P6RSdecayrate, P6RSmaxwgt, P6RSminwgt

P6RSdecayrate = 10000 // 1/(100e-6) m^-1
P6RSmaxwgt = 1.0
P6RSminwgt = 0.0

float P6RSc_P23RSa_prob = 0.041
float P6RSc_P23RSb_prob = 0.041 
float P6RSc_P23RSc_prob = 0.041
float P6RSc_P23RSd_prob = 0.041
float P6RSc_B23FS_prob = 0.041
float P6RSc_P5IBa_prob = 0.041
float P6RSc_P5IBb_prob = 0.041
float P6RSc_P5IBc_prob = 0.041
float P6RSc_P5IBd_prob = 0.041
float P6RSc_B5FS_prob = 0.041
float P6RSc_P6RSa_prob = 0.083
float P6RSc_P6RSb_prob = 0.083
float P6RSc_P6RSc_prob = 0.083
float P6RSc_P6RSd_prob = 0.083
float P6RSc_C23FS_prob = 0.041
float P6RSc_C5FS_prob = 0.041
float P6RSc_ST4RS_prob = 0.041
float P6RSc_I23LTS_prob = 0.041
float P6RSc_I5LTS_prob = 0.041
float P6RSc_TCR_prob = 0.083
float P6RSc_nRT_prob = 0.083
float P6RSc_P23FRBa_prob = 0.041
float P6RSc_P5RSa_prob = 0.041

//P6RSd spatial connection scales

float P6RSdecayrate, P6RSmaxwgt, P6RSminwgt

P6RSdecayrate = 10000 // 1/(100e-6) m^-1
P6RSmaxwgt = 1.0
P6RSminwgt = 0.0

float P6RSd_P23RSa_prob = 0.041
float P6RSd_P23RSb_prob = 0.041 
float P6RSd_P23RSc_prob = 0.041
float P6RSd_P23RSd_prob = 0.041
float P6RSd_B23FS_prob = 0.041
float P6RSd_P5IBa_prob = 0.041
float P6RSd_P5IBb_prob = 0.041
float P6RSd_P5IBc_prob = 0.041
float P6RSd_P5IBd_prob = 0.041
float P6RSd_B5FS_prob = 0.041
float P6RSd_P6RSa_prob = 0.083
float P6RSd_P6RSb_prob = 0.083
float P6RSd_P6RSc_prob = 0.083
float P6RSd_P6RSd_prob = 0.083
float P6RSd_C23FS_prob = 0.041
float P6RSd_C5FS_prob = 0.041
float P6RSd_ST4RS_prob = 0.041
float P6RSd_I23LTS_prob = 0.041
float P6RSd_I5LTS_prob = 0.041
float P6RSd_TCR_prob = 0.083
float P6RSd_nRT_prob = 0.083
float P6RSd_P23FRBa_prob = 0.041
float P6RSd_P5RSa_prob = 0.041

//C23FS spatial connection scales

float C23FSdecayrate, C23FSmaxwgt, C23FSminwgt

C23FSdecayrate = 10000 // 1/(100e-6) m^-1
C23FSmaxwgt = 1.0
C23FSminwgt = 0.0

float C23FS_P23RSa_prob = 0.333
float C23FS_P23RSb_prob = 0.333
float C23FS_P23RSc_prob = 0.333 
float C23FS_P23RSd_prob = 0.333
float C23FS_P5IBa_prob = 0.083
float C23FS_P5IBb_prob = 0.083 
float C23FS_P5IBc_prob = 0.083
float C23FS_P5IBd_prob = 0.083
float C23FS_P6RSa_prob = 0.083
float C23FS_P6RSb_prob = 0.083
float C23FS_P6RSc_prob = 0.083
float C23FS_P6RSd_prob = 0.083
float C23FS_ST4RS_prob = 0.083
float C23FS_P23FRBa_prob = 0.333
float C23FS_P5RSa_prob = 0.083

//C5FS spatial connection scales

float C5FSdecayrate, C5FSmaxwgt, C5FSminwgt

C5FSdecayrate = 10000 // 1/(100e-6) m^-1
C5FSmaxwgt = 1.0
C5FSminwgt = 0.0

float C5FS_P23RSa_prob = 0.083
float C5FS_P23RSb_prob = 0.083
float C5FS_P23RSc_prob = 0.083
float C5FS_P23RSd_prob = 0.083
float C5FS_P5IBa_prob = 0.083
float C5FS_P5IBb_prob = 0.083
float C5FS_P5IBc_prob = 0.083
float C5FS_P5IBd_prob = 0.083
float C5FS_P6RSa_prob = 0.083
float C5FS_P6RSb_prob = 0.083
float C5FS_P6RSc_prob = 0.083
float C5FS_P6RSd_prob = 0.083
float C5FS_ST4RS_prob = 0.083
float C5FS_P23FRBa_prob = 0.083
float C5FS_P5RSa_prob = 0.083

//ST4RS spatial connection scales

float ST4RSdecayrate, ST4RSmaxwgt, ST4RSminwgt

ST4RSdecayrate = 10000 // 1/(100e-6) m^-1
ST4RSmaxwgt = 1.0
ST4RSminwgt = 0.0

float ST4RS_P23RSa_prob = 0.165
float ST4RS_P23RSb_prob = 0.165 
float ST4RS_P23RSc_prob = 0.165
float ST4RS_P23RSd_prob = 0.165
float ST4RS_B23FS_prob = 0.165
float ST4RS_P5IBa_prob = 0.165
float ST4RS_P5IBb_prob = 0.165
float ST4RS_P5IBc_prob = 0.165
float ST4RS_P5IBd_prob = 0.165
float ST4RS_B5FS_prob = 0.165
float ST4RS_P6RSa_prob = 0.165
float ST4RS_P6RSb_prob = 0.165
float ST4RS_P6RSc_prob = 0.165
float ST4RS_P6RSd_prob = 0.165
float ST4RS_C23FS_prob = 0.165
float ST4RS_C5FS_prob = 0.165
float ST4RS_ST4RS_prob = 0.250
float ST4RS_I23LTS_prob = 0.165
float ST4RS_I5LTS_prob = 0.165
float ST4RS_P23FRBa_prob = 0.165
float ST4RS_P5RSa_prob = 0.165

//I23LTS spatial connection scales

float I23LTSdecayrate, I23LTSmaxwgt, I23LTSminwgt

I23LTSdecayrate = 10000 // 1/(100e-6) m^-1
I23LTSmaxwgt = 1.0
I23LTSminwgt = 0.0

float I23LTS_P23RSa_prob = 0.333 
float I23LTS_P23RSb_prob = 0.333
float I23LTS_P23RSc_prob = 0.333 
float I23LTS_P23RSd_prob = 0.333
float I23LTS_B23FS_prob = 0.333
float I23LTS_P5IBa_prob = 0.333
float I23LTS_P5IBb_prob = 0.333
float I23LTS_P5IBc_prob = 0.333 
float I23LTS_P5IBd_prob = 0.333 
float I23LTS_B5FS_prob = 0.333 
float I23LTS_P6RSa_prob = 0.333 
float I23LTS_P6RSb_prob = 0.333
float I23LTS_P6RSc_prob = 0.333 
float I23LTS_P6RSd_prob = 0.333
float I23LTS_C23FS_prob = 0.333
float I23LTS_C5FS_prob = 0.333
float I23LTS_ST4RS_prob = 0.333
float I23LTS_I23LTS_prob = 0.339
float I23LTS_I5LTS_prob = 0.333
float I23LTS_P23FRBa_prob = 0.333
float I23LTS_P5RSa_prob = 0.333

//I5LTS spatial connection scales

float I5LTSdecayrate, I5LTSmaxwgt, I5LTSminwgt

I5LTSdecayrate = 10000 // 1/(100e-6) m^-1
I5LTSmaxwgt = 1.0
I5LTSminwgt = 0.0

float I5LTS_P23RSa_prob = 0.167 
float I5LTS_P23RSb_prob = 0.167
float I5LTS_P23RSc_prob = 0.167 
float I5LTS_P23RSd_prob = 0.167
float I5LTS_B23FS_prob = 0.167
float I5LTS_P5IBa_prob = 0.333
float I5LTS_P5IBb_prob = 0.333
float I5LTS_P5IBc_prob = 0.333 
float I5LTS_P5IBd_prob = 0.333 
float I5LTS_B5FS_prob = 0.333 
float I5LTS_P6RSa_prob = 0.333 
float I5LTS_P6RSb_prob = 0.333
float I5LTS_P6RSc_prob = 0.333 
float I5LTS_P6RSd_prob = 0.333
float I5LTS_C23FS_prob = 0.167
float I5LTS_C5FS_prob = 0.333
float I5LTS_ST4RS_prob = 0.333
float I5LTS_I23LTS_prob = 0.167
float I5LTS_I5LTS_prob = 0.339
float I5LTS_P23FRBa_prob = 0.167
float I5LTS_P5RSa_prob = 0.333

//TCR spatial connection scales

float TCRdecayrate, TCRmaxwgt, TCRminwgt

TCRdecayrate = 10000 // 1/(100e-6) m^-1
TCRmaxwgt = 1.0
TCRminwgt = 0.0

float TCR_P23RSa_prob = 0.167
float TCR_P23RSb_prob = 0.167
float TCR_P23RSc_prob = 0.167 
float TCR_P23RSd_prob = 0.167
float TCR_B23FS_prob = 0.167
float TCR_P5IBa_prob = 0.167
float TCR_P5IBb_prob = 0.167 
float TCR_P5IBc_prob = 0.167
float TCR_P5IBd_prob = 0.167
float TCR_B5FS_prob = 0.333
float TCR_P6RSa_prob = 0.167
float TCR_P6RSb_prob = 0.167
float TCR_P6RSc_prob = 0.167
float TCR_P6RSd_prob = 0.167
float TCR_C23FS_prob = 0.167
float TCR_C5FS_prob = 0.167
float TCR_ST4RS_prob = 0.333
float TCR_nRT_prob = 0.667
float TCR_P23FRBa_prob = 0.167
float TCR_P5RSa_prob = 0.167

//nRT spatial connection scales

float nRTdecayrate, nRTmaxwgt, nRTminwgt

nRTdecayrate = 10000 // 1/(100e-6) m^-1
nRTmaxwgt = 1.0
nRTminwgt = 0.0

float nRT_TCR_prob = 0.50
float nRT_nRT_prob = 0.169

//P23FRBa spatial connection scales

float P23FRBdecayrate, P23FRBmaxwgt, P23FRBminwgt

P23FRBdecayrate = 10000 // 1/(100e-6) m^-1
P23FRBmaxwgt = 1.0
P23FRBminwgt = 0.0

float P23FRBa_P23RSa_prob = 0.20
float P23FRBa_P23RSb_prob = 0.20
float P23FRBa_P23RSc_prob = 0.20
float P23FRBa_P23RSd_prob = 0.20
float P23FRBa_B23FS_prob = 0.20 
float P23FRBa_P5IBa_prob = 0.12
float P23FRBa_P5IBb_prob = 0.12
float P23FRBa_P5IBc_prob = 0.12
float P23FRBa_P5IBd_prob = 0.12
float P23FRBa_B5FS_prob = 0.12
float P23FRBa_P6RSa_prob = 0.04
float P23FRBa_P6RSb_prob = 0.04
float P23FRBa_P6RSc_prob = 0.04
float P23FRBa_P6RSd_prob = 0.04
float P23FRBa_C23FS_prob = 0.20
float P23FRBa_C5FS_prob = 0.12
float P23FRBa_ST4RS_prob = 0.04
float P23FRBa_I23LTS_prob = 0.20
float P23FRBa_I5LTS_prob = 0.12
float P23FRBa_P23FRBa_prob = 0.208
float P23FRBa_P5RSa_prob = 0.12

//P5RSa spatial connection scales

float P5RSdecayrate, P5RSmaxwgt, P5RSminwgt

P5RSdecayrate = 10000 // 1/(100e-6) m^-1
P5RSmaxwgt = 1.0
P5RSminwgt = 0.0

float P5RSa_P23RSa_prob = 0.016
float P5RSa_P23RSb_prob = 0.016
float P5RSa_P23RSc_prob = 0.016 
float P5RSa_P23RSd_prob = 0.016
float P5RSa_B23FS_prob = 0.165
float P5RSa_P5IBa_prob = 0.165
float P5RSa_P5IBb_prob = 0.165
float P5RSa_P5IBc_prob = 0.165
float P5RSa_P5IBd_prob = 0.165
float P5RSa_B5FS_prob = 0.165
float P5RSa_P6RSa_prob = 0.165
float P5RSa_P6RSb_prob = 0.165
float P5RSa_P6RSc_prob = 0.165
float P5RSa_P6RSd_prob = 0.165
float P5RSa_C23FS_prob = 0.165
float P5RSa_C5FS_prob = 0.165
float P5RSa_ST4RS_prob = 0.165
float P5RSa_I23LTS_prob = 0.165 
float P5RSa_I5LTS_prob = 0.165
float P5RSa_P23FRBa_prob = 0.016 
float P5RSa_P5RSa_prob = 0.083

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