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Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)
 
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Simulation Platform
Accession:
20756
This simulation is based on the reference paper listed below. This port was made by Roger D Traub and Maciej T Lazarewicz (mlazarew at seas.upenn.edu) Thanks to Ashlen P Reid for help with porting a morphology of the cell.
Reference:
1 .
Traub RD, Buhl EH, Gloveli T, Whittington MA (2003) Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels.
J Neurophysiol
89
:909-21
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L2/3 pyramidal GLU cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I h;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Dendritic Action Potentials;
Bursting;
Active Dendrites;
Detailed Neuronal Models;
Axonal Action Potentials;
Calcium dynamics;
Implementer(s):
Lazarewicz, Maciej [mlazarew at gmu.edu];
Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB
for information about:
Neocortex L2/3 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I h
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
/
Traub2003
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Figure 2 ( left )
Figure 2 ( right )
Figure 4 Injection 0.6 nA
Figure 4 Injection 1.1 nA
Figure 4 Injection 1.5 nA
Figure 4 Injection 2.5 nA
Figure 5 B1
Figure 5 B2
Figure 6 B1
Figure 6 B2
Figure 7 g_NaP x 0.0
Figure 7 g_NaP x 0.7
Figure 7 g_NaP x 1.0
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