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Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)
 
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Model Information
Model File
Citations
Accession:
217882
" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
Reference:
1 .
Lombardo J, Harrington MA (2016) Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels.
J Neurophysiol
116
:2114-2124
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Spinal motoneuron;
Cell Type(s):
Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s):
I Potassium;
I K;
I Na,t;
I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Axonal Action Potentials;
Implementer(s):
Lombardo, Joseph [josslomb at gmail.com];
Search NeuronDB
for information about:
Spinal cord lumbar motor neuron alpha ACh cell
;
I Na,t
;
I K
;
I M
;
I Potassium
;
/
LombardoHarrington2016
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