"Inhibitory avoidance (IA) training in rodents initiates a molecular
cascade within hippocampal neurons. This cascade contributes to the
transition of short- to long-term memory (i.e., consolidation). Here,
a differential equation-based model was developed to describe a
positive feedback loop within this molecular cascade. The feedback
loop begins with an IA-induced release of brain-derived neurotrophic
factor (BDNF), which in turn leads to rapid phosphorylation of the
cAMP response element-binding protein (pCREB), and a subsequent
increase in the level of the beta isoform of the CCAAT/enhancer binding
protein (C/EBPbeta).
... " See paper for more.
Reference:
1 .
Zhang Y, Smolen P, Alberini CM, Baxter DA, Byrne JH (2016) Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training. Learn Mem 23:714-722 [PubMed]
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