"Synaptic inhibition counterbalances excitation, but it is not known what constitutes optimal
inhibition. We previously proposed that perfect balance is achieved when the peak of an
excitatory postsynaptic potential (EPSP) is exactly at spike threshold, so that the slightest
variation in excitation determines whether a spike is generated. Using simulations, we show
that the optimal inhibitory postsynaptic conductance (IPSG) increases in amplitude and
decay rate as synaptic excitation increases from 1 to 800 Hz. As further proposed by theory,
we show that optimal IPSG parameters can be learned through anti-Hebbian rules. ..."
Kim JK, Fiorillo CD (2017) Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition. Nat Commun 8:14566 [PubMed]