Cerebellar granular layer (Maex and De Schutter 1998)

 Download zip file 
Help downloading and running models
Accession:227363
Circuit model of the granular layer representing a one-dimensional array of single-compartmental granule cells (grcs) and Golgi cells (Gocs). This paper examines the effects of feedback inhibition (grc -> Goc -> grc) versus feedforward inhibition (mossy fibre -> Goc -> grc) on synchronization and oscillatory behaviour.
Reference:
1 . Maex R, De Schutter E (1998) Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. J Neurophysiol 80:2521-37 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule GLU cell; Cerebellum golgi cell;
Channel(s): I Na,t; I A; I h; I K,Ca; I L high threshold; I_KD;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Oscillations;
Implementer(s): Maex, Reinoud [reinoud at bbf.uia.ac.be];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I h; I K,Ca; I_KD; Gaba; Glutamate;
// Morphology file for Granule cell
// A single compartment neuron with a spherical soma representing
// the morphology used in Gabbiani et al. (1994)
// This is a copy of
// /bbf/haddock/carl/Genesis/Granule/True_sa_1_compt_L37/Gran1M0.p
// changed /library/soma to /library/granule/soma on 16/4/96 MAEX
   
*relative

*set_compt_param ELEAK {ELEAK}
*set_compt_param EREST_ACT {EREST_ACT}
*set_compt_param RM	3.0300	// 30 300 ohm.cm^2
*set_compt_param RA	1.0000 	// 
*set_compt_param CM	0.0100	// 1microF/cm^2

*compt /library/granule/soma
   soma		none		0.000	0.000	0.000	10.0 // 25.32


Loading data, please wait...